2024
Effect of Aficamten on Cardiac Structure and Function in Obstructive Hypertrophic Cardiomyopathy SEQUOIA-HCM CMR Substudy
Masri A, Cardoso R, Abraham T, Claggett B, Coats C, Hegde S, Kulac I, Lee M, Maron M, Merkely B, Michels M, Olivotto I, Oreziak A, Jacoby D, Heitner S, Kupfer S, Malik F, Meng L, Solomon S, Wohltman A, Kwong R, Kramer C, Investigators S. Effect of Aficamten on Cardiac Structure and Function in Obstructive Hypertrophic Cardiomyopathy SEQUOIA-HCM CMR Substudy. Journal Of The American College Of Cardiology 2024, 84: 1806-1817. PMID: 39217563, DOI: 10.1016/j.jacc.2024.08.015.Peer-Reviewed Original ResearchCardiovascular magnetic resonanceObstructive hypertrophic cardiomyopathyOutflow tract obstructionReduce cardiovascular eventsCardiac remodelingAtrial fibrillationHeart failureCardiovascular eventsAssociated with progressive heart failureLeft ventricular (LV) hypertrophyPhase 3 double-blindSymptomatic obstructive hypertrophic cardiomyopathyLV outflow tract obstructionMaximal LV wall thicknessLeft atrial volume indexAtrial volume indexLV mass indexLV) hypertrophyPlacebo-controlled trialProgressive heart failureFavorable cardiac remodelingLeft atrial dilatationCardiac myosin inhibitorLeft atrial sizeLV wall thickness
2012
Outcomes of adults with restrictive cardiomyopathy after heart transplantation
DePasquale EC, Nasir K, Jacoby DL. Outcomes of adults with restrictive cardiomyopathy after heart transplantation. The Journal Of Heart And Lung Transplantation 2012, 31: 1269-1275. PMID: 23079066, DOI: 10.1016/j.healun.2012.09.018.Peer-Reviewed Original ResearchConceptsPost-HTx outcomesUnadjusted hazard ratioRestrictive cardiomyopathyRCM patientsHazard ratioCause mortalityHeart transplantationSubgroup analysisRCM groupMultivariate Cox proportional hazards regression analysisCox proportional hazards regression analysisProportional hazards regression analysisTime of HTxProgressive heart failureRadiation/chemotherapyHazards regression analysisOutcomes of adultsPediatric restrictive cardiomyopathySpectrum of disordersAdult HTxRCM diagnosisHeart failurePatient groupSurvival outcomesUnited Network