2023
Pathogenesis and Prediction of Preterm Delivery
Kendle A, Buhimschi C, Lockwood C. Pathogenesis and Prediction of Preterm Delivery. 2023, 344-360. DOI: 10.1002/9781119636540.ch40.Peer-Reviewed Original ResearchPreterm birthPR expressionPlacental corticotropin-releasing hormonePrediction of PTBAdrenal (HPA) axis pathwayCorticotropin-releasing hormoneToll-like receptorsProtease-activated receptorsPreterm deliveryProgesterone receptor inhibitorsDecidual hemorrhageInflammatory cascadeProinflammatory cytokinesInflammatory chemokinesProgesterone activityInterleukin-1βSonographic markersReceptor inhibitorsCortisol releaseInflammation pathwaysMatrix metalloproteinasesAxis pathwayPremature activationBiochemical remodelingProgressive withdrawal
2009
Progestin and Thrombin Regulate Tissue Factor Expression in Human Term Decidual Cells
Lockwood CJ, Murk W, Kayisli UA, Buchwalder LF, Huang S, Funai EF, Krikun G, Schatz F. Progestin and Thrombin Regulate Tissue Factor Expression in Human Term Decidual Cells. The Journal Of Clinical Endocrinology & Metabolism 2009, 94: 2164-2170. PMID: 19276228, PMCID: PMC2690421, DOI: 10.1210/jc.2009-0065.Peer-Reviewed Original ResearchConceptsMaternal-fetal interfaceTerm decidual cellsDecidual cellsTNF-alphaTissue factorPlacental sectionsTF mRNA levelsIL-1betaHuman maternal-fetal interfaceTF expressionWestern blottingTF levelsVillous mesenchymal cellsRT-PCRTerm placental sectionsMRNA levelsHigher histologic scoresTissue factor expressionIL-1beta effectReal-time RT-PCRQuantitative real-time RT-PCRDecidual sectionsHemostatic protectionPreterm deliveryQuantitative RT-PCR