2023
Dysregulated expression of GATA2 and GATA6 transcription factors in adenomyosis: implications for impaired endometrial receptivity
Pavlovic Z, Hsin-Yu Pai A, Hsiao T, Yen C, Alhasan H, Ozmen A, New E, Guo X, Imudia A, Guzeloglu-Kayisli O, Lockwood C, Kayisli U. Dysregulated expression of GATA2 and GATA6 transcription factors in adenomyosis: implications for impaired endometrial receptivity. F&S Science 2023, 5: 92-103. PMID: 37972693, DOI: 10.1016/j.xfss.2023.11.003.Peer-Reviewed Original ResearchHuman endometrial stromal cellsInsulin-like growth factor-binding protein-1Estrogen receptor 1Leukemia inhibitory factorEndometrial stromal cellsProgesterone receptorControl patientsEndometrial sectionsGATA2 overexpressionH-scoreMRNA levelsInhibitory factorStromal cellsGrowth factor-binding protein-1Effect of adenomyosisReproductive-age patientsImpaired endometrial receptivityPotential therapeutic targetYears of ageMessenger RNA levelsEndometrial implantationWestern blot analysisAdenomyosis patientsLIF levelsAge patients
2000
Progestin-Epidermal Growth Factor Regulation of Tissue Factor Expression during Decidualization of Human Endometrial Stromal Cells
Lockwood C. Progestin-Epidermal Growth Factor Regulation of Tissue Factor Expression during Decidualization of Human Endometrial Stromal Cells. The Journal Of Clinical Endocrinology & Metabolism 2000, 85: 297-301. DOI: 10.1210/jc.85.1.297.Peer-Reviewed Original Research
1998
Matrix Metalloproteinase and Matrix Metalloproteinase Inhibitor Expression in Endometrial Stromal Cells during Progestin-Initiated Decidualization and Menstruation-Related Progestin Withdrawal**This work was supported in part by grants from the National Institutes of Health R29-HD29540–01A1 and HD-94–23 (to C.J.L.). Portions of this work were presented at the 44th Annual Meeting of the Society for Gynecologic Investigation. (Lockwood CJ, Krikun G, Hausknecht V, Wang E-Y, Ziegler D, Schatz F, Effects of RU 486 on endometrial stromal cell matrix metalloproteinase and matrix metalloproteinase inhibitor expression. Proceedings of the 44th Annual Meeting of the Society of Gynecologic Investigation, San Diego, CA, 1997, Abstract 220.
Lockwood C, Krikun G, Hausknecht V, Papp C, Schatz F. Matrix Metalloproteinase and Matrix Metalloproteinase Inhibitor Expression in Endometrial Stromal Cells during Progestin-Initiated Decidualization and Menstruation-Related Progestin Withdrawal**This work was supported in part by grants from the National Institutes of Health R29-HD29540–01A1 and HD-94–23 (to C.J.L.). Portions of this work were presented at the 44th Annual Meeting of the Society for Gynecologic Investigation. (Lockwood CJ, Krikun G, Hausknecht V, Wang E-Y, Ziegler D, Schatz F, Effects of RU 486 on endometrial stromal cell matrix metalloproteinase and matrix metalloproteinase inhibitor expression. Proceedings of the 44th Annual Meeting of the Society of Gynecologic Investigation, San Diego, CA, 1997, Abstract 220. Endocrinology 1998, 139: 4607-4613. DOI: 10.1210/en.139.11.4607.Peer-Reviewed Original ResearchSociety for Gynecologic InvestigationExpression of MMP-1Endometrial stromal cellsMMP-1 expressionGynecological investigationSteroid withdrawalImplanting trophoblastEndovascular invasionInhibitor expressionStromal cellsLocal hemorrhageMatrix metalloproteinasesMMP-1Enhanced expressionInhibition of MMP-1 expressionNational Institute
1996
Expression of 11 beta-hydroxysteroid dehydrogenase during decidualization of human endometrial stromal cells
Arcuri F, Monder C, Lockwood C, Schatz F. Expression of 11 beta-hydroxysteroid dehydrogenase during decidualization of human endometrial stromal cells. Endocrinology 1996, 137: 595-600. DOI: 10.1210/en.137.2.595.Peer-Reviewed Original ResearchBeta-HSD expressionBeta-HSD activitySensitivity of mRNA detectionLow-abundance messageHSD activityType I mRNABeta-hydroxysteroid dehydrogenaseI mRNANAD(+)-dependentNADP(+)-dependentSteady state levelsDecidualization of human endometrial stromal cellsRegulates extracellular matrix turnoverNorthern analysisAbundant messageCultured stromal cellsHuman endometrial stromal cellsMedroxyprogesterone acetateBeta-hydroxysteroidEndometrial stromal cellsStromal cellsEnzyme activityTime course measurementsEarly eventExtracellular matrix turnover