Multiple translational isoforms give functional specificity to serum‐ and glucocorticoid‐induced kinase 1 (Sgk1)
Arteaga M, Canessa C. Multiple translational isoforms give functional specificity to serum‐ and glucocorticoid‐induced kinase 1 (Sgk1). The FASEB Journal 2007, 21: a547-a548. DOI: 10.1096/fasebj.21.5.a547-d.Peer-Reviewed Original ResearchN-terminusFunctional specificityEvolutionary distant speciesCore kinase domainFOXO transcriptional factorAlternative translation initiationNumerous cellular processesDifferent cellular compartmentsGlucocorticoid-induced kinase 1Glycogen synthase kinase 3bDiversity of functionsDifferent N-terminiDistant speciesER membraneCellular processesTranslation initiationSingle kinaseCellular compartmentsKinase domainT kinaseTranscriptional factorsDistinct substratesKinase 1ER stressCell survival