2023
Cognitive impairment in pulmonary arterial hypertension
Heller S, See C, Singh I, Fredericks C. Cognitive impairment in pulmonary arterial hypertension. Annals Of Clinical And Translational Neurology 2023, 10: 1899-1903. PMID: 37550957, PMCID: PMC10578884, DOI: 10.1002/acn3.51867.Peer-Reviewed Original ResearchConceptsPulmonary arterial hypertensionCognitive impairmentArterial hypertensionPulmonary artery pressureRight heart dysfunctionPulmonary vascular remodelingCognitive impairment syndromeVascular cognitive impairmentArtery pressureCardiopulmonary exerciseHeart dysfunctionNoninvasive markerCognitive dysfunctionVascular remodelingAdult subjectsImpairmentHypertensionUnderlying mechanismAbnormal increaseDysfunctionSyndromeCognitive evaluationSubjects
2022
Sex differences in default mode network connectivity in healthy aging adults
Ficek-Tani B, Horien C, Ju S, Xu W, Li N, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in default mode network connectivity in healthy aging adults. Cerebral Cortex 2022, 33: 6139-6151. PMID: 36563018, PMCID: PMC10183749, DOI: 10.1093/cercor/bhac491.Peer-Reviewed Original ResearchConceptsDefault mode networkPreclinical Alzheimer's diseaseAlzheimer's diseaseSex differencesBrain connectivity changesDefault mode network connectivityIntrinsic connectivity distributionSeed-based analysisMode network connectivityMedial prefrontal cortexPosterior DMN nodesHealthy aging adultsImpact of sexLifetime riskDMN connectivityWhole brainPosterior cingulateDMN nodesSignificant sex differencesPrefrontal cortexConnectivity changesAging AdultsHealthy participantsDMN functionMode networkPerformance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer’s disease
Wilson E, Young C, Ramos Benitez J, Swarovski M, Feinstein I, Vandijck M, Le Guen Y, Kasireddy N, Shahid M, Corso N, Wang Q, Kennedy G, Trelle A, Lind B, Channappa D, Belnap M, Ramirez V, Skylar-Scott I, Younes K, Yutsis M, Le Bastard N, Quinn J, van Dyck C, Nairn A, Fredericks C, Tian L, Kerchner G, Montine T, Sha S, Davidzon G, Henderson V, Longo F, Greicius M, Wagner A, Wyss-Coray T, Poston K, Mormino E, Andreasson K. Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer’s disease. Alzheimer's Research & Therapy 2022, 14: 172. PMID: 36371232, PMCID: PMC9652927, DOI: 10.1186/s13195-022-01116-2.Peer-Reviewed Original ResearchConceptsPlasma p-tau181Alzheimer's Disease Research CenterP-tau181Disease Research CenterAlzheimer's diseasePositron emission tomographyAD dementiaBlood-based biomarker assaysAmyloid positron emission tomographyTreatment monitoringNovel blood-based biomarkersCSF p-tau181P-tau181 concentrationsDisease-modifying therapiesAβ42/Aβ40 ratioBlood-based biomarkersClinical AD diagnosisDetection of ADMild cognitive impairmentStudy cohortCSF biomarkersPlasma levelsAD groupPrognostic performanceCDR sum
2021
Methylphenidate for Apathy in Alzheimer Disease—Why Should We Care?
Fredericks C. Methylphenidate for Apathy in Alzheimer Disease—Why Should We Care? JAMA Neurology 2021, 78: 1311-1313. PMID: 34570178, DOI: 10.1001/jamaneurol.2021.2942.Peer-Reviewed Original ResearchAssociation of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease.
Trelle AN, Carr VA, Wilson EN, Swarovski MS, Hunt MP, Toueg TN, Tran TT, Channappa D, Corso NK, Thieu MK, Jayakumar M, Nadiadwala A, Guo W, Tanner NJ, Bernstein JD, Litovsky CP, Guerin SA, Khazenzon AM, Harrison MB, Rutt BK, Deutsch GK, Chin FT, Davidzon GA, Hall JN, Sha SJ, Fredericks CA, Andreasson KI, Kerchner GA, Wagner AD, Mormino EC. Association of CSF Biomarkers With Hippocampal-Dependent Memory in Preclinical Alzheimer Disease. Neurology 2021, 96: e1470-e1481. PMID: 33408146, PMCID: PMC8055319, DOI: 10.1212/wnl.0000000000011477.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAgingAlzheimer DiseaseAmyloid beta-PeptidesAssociation LearningBiomarkersCross-Sectional StudiesCuesDiscrimination, PsychologicalFemaleHippocampusHumansMaleMemoryMemory DisordersMemory, EpisodicMental RecallMiddle AgedNeuropsychological TestsPeptide FragmentsPsychomotor PerformanceTau ProteinsConceptsMemory taskHippocampal functionMnemonic discrimination taskMnemonic discrimination performanceUnimpaired older adultsHippocampal-dependent memoryPreclinical Alzheimer's diseaseEpisodic memoryPreclinical AD pathologyIndividual differencesMemory assessmentMemory performanceDiscrimination taskTask difficultyAssociative memoryDiscrimination performanceSingle batch analysisCross-sectional relationshipMemory studiesOlder adultsMemoryAlzheimer's disease biomarkersCSF β-amyloidElevated p-tauRecall
2020
Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases
Mormino EC, Toueg TN, Azevedo C, Castillo JB, Guo W, Nadiadwala A, Corso NK, Hall JN, Fan A, Trelle AN, Harrison MB, Hunt MP, Sha SJ, Deutsch G, James M, Fredericks CA, Koran ME, Zeineh M, Poston K, Greicius MD, Khalighi M, Davidzon GA, Shen B, Zaharchuk G, Wagner AD, Chin FT. Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 2233-2244. PMID: 32572562, PMCID: PMC7755737, DOI: 10.1007/s00259-020-04923-7.Peer-Reviewed Original ResearchConceptsStandardized uptake value ratioAlzheimer's diseaseHealthy controlsCourse of ADSemantic variant primary progressive aphasiaVariant primary progressive aphasiaNeurofibrillary tangle pathologyOlder healthy controlsUptake value ratioPrimary progressive aphasiaAnterior temporal poleMedial temporal lobeNovel PET ligandMethodsForty-nine participantsTangle pathologyTau-PETSvPPA patientsFocal uptakeEarly diagnosisSubtle elevationRobust elevationTemporal lobeHC groupProgressive aphasiaPET ligandHippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults
Trelle AN, Carr VA, Guerin SA, Thieu MK, Jayakumar M, Guo W, Nadiadwala A, Corso NK, Hunt MP, Litovsky CP, Tanner NJ, Deutsch GK, Bernstein JD, Harrison MB, Khazenzon AM, Jiang J, Sha SJ, Fredericks CA, Rutt BK, Mormino EC, Kerchner GA, Wagner AD. Hippocampal and cortical mechanisms at retrieval explain variability in episodic remembering in older adults. ELife 2020, 9: e55335. PMID: 32469308, PMCID: PMC7259949, DOI: 10.7554/elife.55335.Peer-Reviewed Original ResearchConceptsHippocampal pattern completionCortical reinstatementEpisodic memoryHippocampal activityOlder adultsPattern completionAge-related episodic memory declineTrial-unique associationsTrial-wise analysesEpisodic memory declineNormal older adultsEpisodic rememberingFMRI indicesMemory variabilityIndividual differencesUnique varianceAssociative retrievalMemory declineCortical mechanismsFMRI dataReinstatementMemoryAdultsRetrievalRemembering
2019
Relative preservation of facial expression recognition in posterior cortical atrophy.
Pressman PS, Gola K, Shdo SM, Miller BL, Fredericks C, Mielke C, Pelak V, Rankin KP. Relative preservation of facial expression recognition in posterior cortical atrophy. Neurology 2019, 92: e1064-e1071. PMID: 30760634, PMCID: PMC6442010, DOI: 10.1212/wnl.0000000000007075.Peer-Reviewed Original ResearchConceptsPosterior cortical atrophyBehavioral variant frontotemporal dementiaAlzheimer's diseaseCortical atrophyHealthy controlsVariant frontotemporal dementiaObservational studyRelative preservationAffective blindsightBvFTD groupFrontotemporal dementiaPatientsGroup differencesAtrophyGroupDementiaDisease
2018
Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar?
Fredericks CA, Brown JA, Deng J, Kramer A, Ossenkoppele R, Rankin K, Kramer JH, Miller BL, Rabinovici GD, Seeley WW. Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar? NeuroImage Clinical 2018, 21: 101628. PMID: 30528957, PMCID: PMC6411779, DOI: 10.1016/j.nicl.2018.101628.Peer-Reviewed Original ResearchConceptsPosterior cortical atrophyVisuospatial networkAlzheimer's diseaseClinical featuresCortical atrophyPulvinar nucleusSN connectivityConnectivity changesPulvinar thalamic nucleiPatients' clinical featuresAmnestic Alzheimer's diseaseMedial pulvinar nucleusLateral pulvinar nucleusDefault mode network connectivitySalience network connectivityMore depressive symptomsMode network connectivityStandardized neuropsychological batteryTask-free fMRIIntrinsic connectivity networksDirect anatomical connectionsVisuospatial symptomsConnectivity increasesBrain atrophyPCa patients
2015
Predicting success: What medical student measures predict resident performance in neurology?
Burish MJ, Fredericks CA, Engstrom JW, Tateo VL, Josephson SA. Predicting success: What medical student measures predict resident performance in neurology? Clinical Neurology And Neurosurgery 2015, 135: 69-72. PMID: 26038279, DOI: 10.1016/j.clineuro.2015.05.007.Peer-Reviewed Original Research
2014
A case of progressive multifocal leukoencephalopathy in a lupus patient treated with belimumab
Fredericks C, Kvam K, Bear J, Crabtree G, Josephson. A case of progressive multifocal leukoencephalopathy in a lupus patient treated with belimumab. Lupus 2014, 23: 711-713. PMID: 24531080, DOI: 10.1177/0961203314524292.Peer-Reviewed Original ResearchConceptsProgressive multifocal leukoencephalopathySystemic lupus erythematosusMultifocal leukoencephalopathyAutoantibody-positive systemic lupus erythematosusDevelopment of PMLMild systemic lupus erythematosusTrials of belimumabProgressive neurologic declineFatal adverse effectsSoluble B lymphocyte stimulatorB lymphocyte stimulatorB cell maturationJCV PCRLupus patientsNeurologic declineSymptom onsetAutonomic symptomsLupus erythematosusT2 hyperintensityAutoimmune diseasesStandard treatmentBelimumabWhite matterEpisodic dystoniaCareful monitoring
2012
Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala–anterior paralimbic neural system
Blond BN, Fredericks CA, Blumberg HP. Functional neuroanatomy of bipolar disorder: structure, function, and connectivity in an amygdala–anterior paralimbic neural system. Bipolar Disorders 2012, 14: 340-355. PMID: 22631619, PMCID: PMC3880745, DOI: 10.1111/j.1399-5618.2012.01015.x.Peer-Reviewed Original Research
2009
Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions
Fredericks CA, Drabant EM, Edge MD, Tillie JM, Hallmayer J, Ramel W, Kuo JR, Mackey S, Gross JJ, Dhabhar FS. Healthy young women with serotonin transporter SS polymorphism show a pro-inflammatory bias under resting and stress conditions. Brain Behavior And Immunity 2009, 24: 350-357. PMID: 19883751, PMCID: PMC2826575, DOI: 10.1016/j.bbi.2009.10.014.Peer-Reviewed Original ResearchConceptsPro-inflammatory biasTrier Social Stress TestLower anti-inflammatory cytokinesChronic pro-inflammatory stateIL-6/ILHigher IL-6/ILSerum IL-6Anti-inflammatory cytokinesPro-inflammatory stateHealthy young womenPro-inflammatory cytokinesSS individualsLife stressLow exposureStress testPromoter region polymorphismsIL-10IL-6Relevant biological effectsRecent life stressSocial Stress TestHealthy subjectsNeurobiological effectsClinical relevanceLL individuals
2008
Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder
Chepenik LG, Fredericks C, Papademetris X, Spencer L, Lacadie C, Wang F, Pittman B, Duncan JS, Staib LH, Duman RS, Gelernter J, Blumberg HP. Effects of the Brain-Derived Neurotrophic Growth Factor Val66Met Variation on Hippocampus Morphology in Bipolar Disorder. Neuropsychopharmacology 2008, 34: 944-951. PMID: 18704093, PMCID: PMC2837582, DOI: 10.1038/npp.2008.107.Peer-Reviewed Original ResearchConceptsSmaller hippocampus volumesHippocampus volumeBipolar disorderBDNF genotypeBD diagnosisMood disorder pathophysiologyBDNF Val66Met polymorphismHigh-resolution magnetic resonanceHealthy comparison subjectsVal/Val homozygotesEffect of diagnosisLinear mixed model analysisVal66Met polymorphismGrowth factor proteinBD subgroupsDisorder pathophysiologyHC subjectsHippocampal developmentComparison subjectsMixed model analysisHippocampus structureBDNFHippocampus morphologyAnterior hippocampusVal homozygotes
2005
Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder
Blumberg HP, Fredericks C, Wang F, Kalmar JH, Spencer L, Papademetris X, Pittman B, Martin A, Peterson BS, Fulbright RK, Krystal JH. Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disorders 2005, 7: 570-576. PMID: 16403182, PMCID: PMC2291299, DOI: 10.1111/j.1399-5618.2005.00264.x.Peer-Reviewed Original ResearchConceptsAmygdala volumeBipolar disorderYoung adultsAmygdala volume abnormalitiesTotal brain volumeHigh-resolution magnetic resonancePreliminary evidenceSubjects longitudinal designPersistent abnormalitiesMixed-model statistical analysisBD IVolume abnormalitiesHealthy comparison participantsBrain volumeHealthy participantsAbnormalitiesAdultsAdolescentsComparison participantsAmygdalaDevelopmental epochsDisordersLongitudinal designParticipantsMagnetic resonance
2003
A Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal Cortices
Blumberg HP, Leung HC, Skudlarski P, Lacadie CM, Fredericks CA, Harris BC, Charney DS, Gore JC, Krystal JH, Peterson BS. A Functional Magnetic Resonance Imaging Study of Bipolar Disorder: State- and Trait-Related Dysfunction in Ventral Prefrontal Cortices. JAMA Psychiatry 2003, 60: 601-609. PMID: 12796223, DOI: 10.1001/archpsyc.60.6.601.Peer-Reviewed Original ResearchConceptsVentral prefrontal cortexBipolar disorderPrefrontal cortexMood statesMagnetic resonance imaging studyHealthy control subjectsAcute mood statesLeft ventral prefrontal cortexResonance imaging studySignal changesDisturbances of attentionFunctional magnetic resonance imaging studyAnterior cingulate cortexBipolar disorder IDorsal anterior cingulateEvent-related functional magnetic resonanceFunctional magnetic resonanceAcute episodeControl subjectsExaggerated increaseFunctional impairmentBlunted activationMood episodesSpecific mood statesPrefrontal abnormalities