2024
Medial amygdalar tau is associated with mood symptoms in preclinical Alzheimer’s disease
Li J, Tun S, Ficek-Tani B, Xu W, Wang S, Horien C, Toyonaga T, Nuli S, Zeiss C, Powers A, Zhao Y, Mormino E, Fredericks C. Medial amygdalar tau is associated with mood symptoms in preclinical Alzheimer’s disease. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2024 PMID: 39059466, DOI: 10.1016/j.bpsc.2024.07.012.Peer-Reviewed Original ResearchAssociated with mood symptomsMood symptomsAmyloid-positive individualsMedial amygdalaSeed-based functional connectivity analysisAssociated with anxiety symptomsSelf-reported mood symptomsPost hoc correlation analysisAlzheimer's diseaseFunctional connectivity analysisPreclinical Alzheimer's diseaseTau bindingOrbitofrontal cortexTau depositionAmygdalar connectivityEmotional processingAnxiety symptomsRetrosplenial cortexBetween-group differencesAmygdalaFunctional connectivityLateral amygdalaConnectivity analysisDepression scoresNeuropsychiatric symptoms
2023
Connectome-based predictive modeling shows sex differences in brain-based predictors of memory performance
Ju S, Horien C, Shen X, Abuwarda H, Trainer A, Constable R, Fredericks C. Connectome-based predictive modeling shows sex differences in brain-based predictors of memory performance. Frontiers In Dementia 2023, 2: 1126016. PMID: 39082002, PMCID: PMC11285565, DOI: 10.3389/frdem.2023.1126016.Peer-Reviewed Original ResearchDefault mode networkConnectome-based predictive modelingMemory performanceMemory taskMemory scoresShort-term memory performanceBrain-based predictorsShort-term memoryPosterior default mode networkAmnestic Alzheimer's diseaseRecollective memoryDMN activityMode networkVisual networkPast researchSex-specific modelsVisual circuitryAlzheimer's diseaseSex differencesMemoryDifferent circuitryTaskElevated riskMachine learning approachesNetwork activity
2022
Sex differences in default mode network connectivity in healthy aging adults
Ficek-Tani B, Horien C, Ju S, Xu W, Li N, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in default mode network connectivity in healthy aging adults. Cerebral Cortex 2022, 33: 6139-6151. PMID: 36563018, PMCID: PMC10183749, DOI: 10.1093/cercor/bhac491.Peer-Reviewed Original ResearchConceptsDefault mode networkPreclinical Alzheimer's diseaseAlzheimer's diseaseSex differencesBrain connectivity changesDefault mode network connectivityIntrinsic connectivity distributionSeed-based analysisMode network connectivityMedial prefrontal cortexPosterior DMN nodesHealthy aging adultsImpact of sexLifetime riskDMN connectivityWhole brainPosterior cingulateDMN nodesSignificant sex differencesPrefrontal cortexConnectivity changesAging AdultsHealthy participantsDMN functionMode networkRobust prediction of memory and neuroticism in men and women using connectome‐based predictive modeling
Ju S, Horien C, Constable T, Fredericks C. Robust prediction of memory and neuroticism in men and women using connectome‐based predictive modeling. Alzheimer's & Dementia 2022, 18 DOI: 10.1002/alz.063015.Peer-Reviewed Original ResearchConnectome-based predictive modelingAlzheimer's diseaseRAVLT measuresFunctional MRI scansBackground Alzheimer's diseaseHealthy womenNeurobehavioral scoresHealthy subjectsHigh riskMemory performanceMRI scansBrain circuitryBrain connectivityWomenMenSexBrain connectomeDiseasePearson correlationScoresPredictorsConnectivity matrixBrain-based predictorsBehavioral measuresSubjectsPerformance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer’s disease
Wilson E, Young C, Ramos Benitez J, Swarovski M, Feinstein I, Vandijck M, Le Guen Y, Kasireddy N, Shahid M, Corso N, Wang Q, Kennedy G, Trelle A, Lind B, Channappa D, Belnap M, Ramirez V, Skylar-Scott I, Younes K, Yutsis M, Le Bastard N, Quinn J, van Dyck C, Nairn A, Fredericks C, Tian L, Kerchner G, Montine T, Sha S, Davidzon G, Henderson V, Longo F, Greicius M, Wagner A, Wyss-Coray T, Poston K, Mormino E, Andreasson K. Performance of a fully-automated Lumipulse plasma phospho-tau181 assay for Alzheimer’s disease. Alzheimer's Research & Therapy 2022, 14: 172. PMID: 36371232, PMCID: PMC9652927, DOI: 10.1186/s13195-022-01116-2.Peer-Reviewed Original ResearchConceptsPlasma p-tau181Alzheimer's Disease Research CenterP-tau181Disease Research CenterAlzheimer's diseasePositron emission tomographyAD dementiaBlood-based biomarker assaysAmyloid positron emission tomographyTreatment monitoringNovel blood-based biomarkersCSF p-tau181P-tau181 concentrationsDisease-modifying therapiesAβ42/Aβ40 ratioBlood-based biomarkersClinical AD diagnosisDetection of ADMild cognitive impairmentStudy cohortCSF biomarkersPlasma levelsAD groupPrognostic performanceCDR sum
2021
Sex differences in connectivity in the default mode network in healthy aging adults
Ficek B, Horien C, Lacadie C, Shen X, Scheinost D, Constable T, Fredericks C. Sex differences in connectivity in the default mode network in healthy aging adults. Alzheimer's & Dementia 2021, 17 DOI: 10.1002/alz.056050.Peer-Reviewed Original ResearchIntrinsic connectivity distributionDefault mode networkAlzheimer's diseaseHealthy aging adultsElevated riskAging AdultsLarge cross-sectional studyPosterior default mode networkSex differencesMode networkCross-sectional cohortCross-sectional studyPreclinical Alzheimer's diseaseSymptomatic Alzheimer's diseaseResting-state scansSex-based differencesAnterior nodeAD showDMN connectivityHealthy adultsFunctional MRI dataNormal individualsResults FemalesZ-scoreFunctional connectivity
2020
Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases
Mormino EC, Toueg TN, Azevedo C, Castillo JB, Guo W, Nadiadwala A, Corso NK, Hall JN, Fan A, Trelle AN, Harrison MB, Hunt MP, Sha SJ, Deutsch G, James M, Fredericks CA, Koran ME, Zeineh M, Poston K, Greicius MD, Khalighi M, Davidzon GA, Shen B, Zaharchuk G, Wagner AD, Chin FT. Tau PET imaging with 18F-PI-2620 in aging and neurodegenerative diseases. European Journal Of Nuclear Medicine And Molecular Imaging 2020, 48: 2233-2244. PMID: 32572562, PMCID: PMC7755737, DOI: 10.1007/s00259-020-04923-7.Peer-Reviewed Original ResearchConceptsStandardized uptake value ratioAlzheimer's diseaseHealthy controlsCourse of ADSemantic variant primary progressive aphasiaVariant primary progressive aphasiaNeurofibrillary tangle pathologyOlder healthy controlsUptake value ratioPrimary progressive aphasiaAnterior temporal poleMedial temporal lobeNovel PET ligandMethodsForty-nine participantsTangle pathologyTau-PETSvPPA patientsFocal uptakeEarly diagnosisSubtle elevationRobust elevationTemporal lobeHC groupProgressive aphasiaPET ligand
2019
P4‐576: CONCORDANCE BETWEEN 18F‐PI‐2620 TAU PET/MRI IMAGING AND CLINICAL OUTCOMES IN ALZHEIMER DISEASE AND OTHER TAUOPATHIES
Koran M, Davidzon G, Azevedo C, Toueg T, Nadiadwala A, Castillo J, Hall J, Sha S, Fredericks C, Greicius M, Wagner A, Zaharchuk G, Chin F, Mormino E. P4‐576: CONCORDANCE BETWEEN 18F‐PI‐2620 TAU PET/MRI IMAGING AND CLINICAL OUTCOMES IN ALZHEIMER DISEASE AND OTHER TAUOPATHIES. Alzheimer's & Dementia 2019, 15: p1541-p1541. DOI: 10.1016/j.jalz.2019.08.124.Peer-Reviewed Original ResearchRelative preservation of facial expression recognition in posterior cortical atrophy.
Pressman PS, Gola K, Shdo SM, Miller BL, Fredericks C, Mielke C, Pelak V, Rankin KP. Relative preservation of facial expression recognition in posterior cortical atrophy. Neurology 2019, 92: e1064-e1071. PMID: 30760634, PMCID: PMC6442010, DOI: 10.1212/wnl.0000000000007075.Peer-Reviewed Original ResearchConceptsPosterior cortical atrophyBehavioral variant frontotemporal dementiaAlzheimer's diseaseCortical atrophyHealthy controlsVariant frontotemporal dementiaObservational studyRelative preservationAffective blindsightBvFTD groupFrontotemporal dementiaPatientsGroup differencesAtrophyGroupDementiaDisease
2018
Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar?
Fredericks CA, Brown JA, Deng J, Kramer A, Ossenkoppele R, Rankin K, Kramer JH, Miller BL, Rabinovici GD, Seeley WW. Intrinsic connectivity networks in posterior cortical atrophy: A role for the pulvinar? NeuroImage Clinical 2018, 21: 101628. PMID: 30528957, PMCID: PMC6411779, DOI: 10.1016/j.nicl.2018.101628.Peer-Reviewed Original ResearchConceptsPosterior cortical atrophyVisuospatial networkAlzheimer's diseaseClinical featuresCortical atrophyPulvinar nucleusSN connectivityConnectivity changesPulvinar thalamic nucleiPatients' clinical featuresAmnestic Alzheimer's diseaseMedial pulvinar nucleusLateral pulvinar nucleusDefault mode network connectivitySalience network connectivityMore depressive symptomsMode network connectivityStandardized neuropsychological batteryTask-free fMRIIntrinsic connectivity networksDirect anatomical connectionsVisuospatial symptomsConnectivity increasesBrain atrophyPCa patientsEarly affective changes and increased connectivity in preclinical Alzheimer's disease
Fredericks CA, Sturm VE, Brown JA, Hua AY, Bilgel M, Wong DF, Resnick SM, Seeley WW. Early affective changes and increased connectivity in preclinical Alzheimer's disease. Alzheimer's & Dementia Diagnosis Assessment & Disease Monitoring 2018, 10: 471-479. PMID: 30302368, PMCID: PMC6174255, DOI: 10.1016/j.dadm.2018.06.002.Peer-Reviewed Original ResearchAffective changesEmotional reactivityPreclinical Alzheimer's diseaseInterpersonal warmthSocial-emotional processingEnhanced emotional reactivitySuperior temporal sulcusNormal older adultsSalience network connectivityHigher functional connectivityAmyloid-positive individualsHigh global connectivityMild Alzheimer's diseaseTemporal sulcusSalience networkSignificant stimuliRight insulaFunctional connectivityCognitive declineOlder adultsAffective symptomsAlzheimer's diseaseLongitudinal assessmentKey regionsWarmth