Caroline Hendry, PhD
Research ScientistCards
Appointments
Additional Titles
Scientific Director; Advisor to the Chair, Genetics
Director, Office for Strategic Research Development, Genetics
Contact Info
Appointments
Additional Titles
Scientific Director; Advisor to the Chair, Genetics
Director, Office for Strategic Research Development, Genetics
Contact Info
Appointments
Additional Titles
Scientific Director; Advisor to the Chair, Genetics
Director, Office for Strategic Research Development, Genetics
Contact Info
About
Non nobis solum nati sumus
(Not for ourselves alone are we born - Marcus Tallius Cicero)
Titles
Research Scientist
Scientific Director; Advisor to the Chair, Genetics; Director, Office for Strategic Research Development, Genetics
Biography
Caroline is the Scientific Director and Advisor to the Chair of Genetics at Yale School of Medicine. She is also the Director of the Office for Strategic Research Development, responsible for increasing research innovation and discovery through strategic portfolio planning, advisory and collaboration. Caroline leads cross-functional capacity building activities in high growth areas including rare disease research, population/preventative health screening, and IND-enabling R&D for gene- and cell-based therapies. She plays a key role in enabling highly efficient operational processes/systems across basic and clinical research.
Caroline was born in Brisbane, Australia and earned her undergraduate degree in Genetics at the University of Queensland, Australia. She earned her PhD in developmental genetics under Prof Melissa Little at the Institute for Molecular Bioscience and her postdoc in molecular reprogramming under Prof Ihor Lemishka at the Mount Sinai School of Medicine, NY. Following her postdoc, Caroline moved to Cambridge, UK, where she took on a new role as Reviews Editor for the journal Development, covering the stem cells and regeneration fields.
Caroline was recruited to Yale in 2018 and is a co-Investigator on several large NIH grants in the clinical-translational space. In addition to her scientific training, she has extensive experience in project management, leadership and research administration. She is currently completing her MBA degree at the Yale School of Management, specializing in the healthcare sector.
Appointments
Genetics
Research ScientistPrimary
Other Departments & Organizations
Education & Training
- MBA
- Yale School of Management (2026)
- Postdoctoral Scientist
- Mount Sinai School of Medicine (2012)
- PhD
- Institute for Molecular Bioscience, Molecular Biology (2010)
- BSc (Hon)
- University of Queensland, Genetics (2006)
Research
Overview
My main research interests are the discovery of rare and undiagnosed diseases as well as the development of highly innovative genetic and genomic technologies, including CRISPR-based approaches for gene therapy and new tools for clinical diagnostics. I am also interested in the development and implementation of value-based care models and in particular population/preventative health screening and the use of AI to improve the efficiency of clinical evaluation and diagnosis.
Publications
2024
Stem cell migration drives lung repair in living mice
Chioccioli M, Liu S, Magruder S, Tata A, Borriello L, McDonough J, Konkimalla A, Kim S, Nouws J, Gonzalez D, Traub B, Ye X, Yang T, Entenberg D, Krishnaswamy S, Hendry C, Kaminski N, Tata P, Sauler M. Stem cell migration drives lung repair in living mice. Developmental Cell 2024, 59: 830-840.e4. PMID: 38377991, PMCID: PMC11003834, DOI: 10.1016/j.devcel.2024.02.003.Peer-Reviewed Original ResearchCitationsAltmetricConceptsStem cell migrationCell migrationAlveolar type 2 cellsAlveolar unitsStem cell motilityAlveolar type 1 cellsStem cell activityCellular response to injuryResponse to injuryType 2 cellsMotile phenotypeType 1 cellsCell motilityLung repairImpaired regenerationGenetic depletionCell activationAT2Stem cellsTissue repairAT1Longitudinal imagingInjuryMotilityCellular resolution
2023
The scientific director: A complimentary model for academic leadership
Hendry C, Giraldez A. The scientific director: A complimentary model for academic leadership. Cell 2023, 186: 2951-2955. PMID: 37419083, DOI: 10.1016/j.cell.2023.05.036.Peer-Reviewed Original ResearchCitationsAltmetricMeSH KeywordsCell cycle controls long-range calcium signaling in the regenerating epidermis
Moore J, Bhaskar D, Gao F, Matte-Martone C, Du S, Lathrop E, Ganesan S, Shao L, Norris R, Sanz N, Annusver K, Kasper M, Cox A, Hendry C, Rieck B, Krishnaswamy S, Greco V. Cell cycle controls long-range calcium signaling in the regenerating epidermis. Journal Of Cell Biology 2023, 222: e202302095. PMID: 37102999, PMCID: PMC10140546, DOI: 10.1083/jcb.202302095.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and Concepts
2022
The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation
Miao L, Tang Y, Bonneau AR, Chan SH, Kojima ML, Pownall ME, Vejnar CE, Gao F, Krishnaswamy S, Hendry CE, Giraldez AJ. The landscape of pioneer factor activity reveals the mechanisms of chromatin reprogramming and genome activation. Molecular Cell 2022, 82: 986-1002.e9. PMID: 35182480, PMCID: PMC9327391, DOI: 10.1016/j.molcel.2022.01.024.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsGenome activationChromatin openingTranscription factorsPioneer factor activityDifferent transcription factorsChromatin reprogrammingPioneer factorsNucleosome positionsActive enhancersIndividual genesCore histonesTriple mutantGene activationTF inputsDevelopmental transitionsSequence contextCell typesFactor activityHistonesPioneering activityEnhancerActivationSequence of eventsPou5f3ChromatinPrdm6 controls heart development by regulating neural crest cell differentiation and migration
Hong L, Li N, Gasque V, Mehta S, Ye L, Wu Y, Li J, Gewies A, Ruland J, Hirschi KK, Eichmann A, Hendry C, van Dijk D, Mani A. Prdm6 controls heart development by regulating neural crest cell differentiation and migration. JCI Insight 2022, 7: e156046. PMID: 35108221, PMCID: PMC8876496, DOI: 10.1172/jci.insight.156046.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsCardiac NCCNeural crest cell fateNeural crest cell differentiationSingle-cell RNA-seq analysisRNA-seq analysisDorsal neural tubeG1-S progressionFate-mapping approachCNCC migrationSpecification genesH4K20 monomethylationCell fateTranscriptomic analysisEpigenetic modifiersHeart developmentRegulated networkTranscript levelsKey regulatorMolecular mechanismsCell differentiationNeural tubePRDM6Ductus arteriosusPotential targetDifferentiation
2017
Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity.
Carcamo-Orive I, Hoffman GE, Cundiff P, Beckmann ND, D'Souza SL, Knowles JW, Patel A, Papatsenko D, Abbasi F, Reaven GM, Whalen S, Lee P, Shahbazi M, Henrion MYR, Zhu K, Wang S, Roussos P, Schadt EE, Pandey G, Chang R, Quertermous T, Lemischka I. Analysis of Transcriptional Variability in a Large Human iPSC Library Reveals Genetic and Non-genetic Determinants of Heterogeneity. Cell Stem Cell 2017, 20: 518-532.e9. PMID: 28017796, DOI: 10.1016/j.stem.2016.11.005.Peer-Reviewed Original Research
2013
Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors.
Hendry CE, Vanslambrouck JM, Ineson J, Suhaimi N, Takasato M, Rae F, Little MH. Direct transcriptional reprogramming of adult cells to embryonic nephron progenitors. Journal Of The American Society Of Nephrology : JASN 2013, 24: 1424-34. PMID: 23766537, PMCID: PMC3752949, DOI: 10.1681/ASN.2012121143.Peer-Reviewed Original ResearchInduction of a hemogenic program in mouse fibroblasts.
Pereira CF, Chang B, Qiu J, Niu X, Papatsenko D, Hendry CE, Clark NR, Nomura-Kitabayashi A, Kovacic JC, Ma'ayan A, Schaniel C, Lemischka IR, Moore K. Induction of a hemogenic program in mouse fibroblasts. Cell Stem Cell 2013, 13: 205-18. PMID: 23770078, PMCID: PMC3735774, DOI: 10.1016/j.stem.2013.05.024.Peer-Reviewed Original Research
2012
Reprogramming the kidney: a novel approach for regeneration.
Hendry CE, Little MH. Reprogramming the kidney: a novel approach for regeneration. Kidney International 2012, 82: 138-46. PMID: 22437414, DOI: 10.1038/ki.2012.68.Peer-Reviewed Original Research
2011
Defining and redefining the nephron progenitor population.
Hendry C, Rumballe B, Moritz K, Little MH. Defining and redefining the nephron progenitor population. Pediatric Nephrology (Berlin, Germany) 2011, 26: 1395-406. PMID: 21229268, PMCID: PMC3189495, DOI: 10.1007/s00467-010-1750-4.Peer-Reviewed Original Research
News
News
- September 10, 2024
NIH Recognizes Yale’s Expertise in the Genetics of Rare Diseases
- February 10, 2022
Yale Scientists Identify a Gene That Can Repair Congenital Heart Defects
- August 27, 2021
Collective Efforts to Increase Diversity, Equity, and Inclusion in the Genetics Department Make Steady Progress
- February 16, 2021
Diverse Junior Scientists Display Their Talents and Learn to Navigate Academia