2021
Infection with endosymbiotic Spiroplasma disrupts tsetse (Glossina fuscipes fuscipes) metabolic and reproductive homeostasis
Son JH, Weiss BL, Schneider DI, Dera KM, Gstöttenmayer F, Opiro R, Echodu R, Saarman NP, Attardo GM, Onyango M, Abdalla A, Aksoy S. Infection with endosymbiotic Spiroplasma disrupts tsetse (Glossina fuscipes fuscipes) metabolic and reproductive homeostasis. PLOS Pathogens 2021, 17: e1009539. PMID: 34529715, PMCID: PMC8478229, DOI: 10.1371/journal.ppat.1009539.Peer-Reviewed Original ResearchConceptsReproductive fitnessSpiroplasma infectionSex-biased gene expressionHigh-throughput RNA sequencingReproductive physiologyIntrauterine larval developmentMale reproductive fitnessPathogenic African trypanosomesEndosymbiotic bacteriaFly resistanceTsetse fecundityFemale spermathecaFemale fecundityRNA sequencingLarval developmentSpiroplasmaGene expressionAfrican trypanosomesReproductive tissuesReproductive homeostasisTsetse hostHuman diseasesPopulation sizeProtective phenotypeLab linesParatransgenic manipulation of a tsetse microRNA alters the physiological homeostasis of the fly’s midgut environment
Yang L, Weiss BL, Williams AE, Aksoy E, de Silva Orfano A, Son JH, Wu Y, Vigneron A, Karakus M, Aksoy S. Paratransgenic manipulation of a tsetse microRNA alters the physiological homeostasis of the fly’s midgut environment. PLOS Pathogens 2021, 17: e1009475. PMID: 34107000, PMCID: PMC8216540, DOI: 10.1371/journal.ppat.1009475.Peer-Reviewed Original ResearchConceptsGut lumenCurrent disease control methodsTsetse's PMMidgut environmentTsetse's abilityAbundant secretory proteinsPeritrophic matrixInfection outcomesTrypanosome infection prevalenceChemotherapeutic treatmentParatransgenic manipulationInfected peopleEtiological agentInfection prevalenceInfectionInfection establishmentParasitic African trypanosomesCardiaSignificant increaseNon-coding RNAsPhysiological homeostasisMolecular cascadesBlood digestionSmall non-coding RNAsParatransgenic tsetse
2012
Enhancing tsetse fly refractoriness to trypanosome infection – A new IAEA coordinated research project
Van Den Abbeele J, Bourtzis K, Weiss B, Cordón-Rosales C, Miller W, Abd-alla AM, Parker A. Enhancing tsetse fly refractoriness to trypanosome infection – A new IAEA coordinated research project. Journal Of Invertebrate Pathology 2012, 112: s142-s147. PMID: 22841950, DOI: 10.1016/j.jip.2012.07.020.Peer-Reviewed Original Research