2021
Paratransgenic manipulation of a tsetse microRNA alters the physiological homeostasis of the fly’s midgut environment
Yang L, Weiss BL, Williams AE, Aksoy E, de Silva Orfano A, Son JH, Wu Y, Vigneron A, Karakus M, Aksoy S. Paratransgenic manipulation of a tsetse microRNA alters the physiological homeostasis of the fly’s midgut environment. PLOS Pathogens 2021, 17: e1009475. PMID: 34107000, PMCID: PMC8216540, DOI: 10.1371/journal.ppat.1009475.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAnimals, Genetically ModifiedGastrointestinal MicrobiomeGenes, InsectHomeostasisInsect VectorsIntestinesMicroRNAsTrypanosomaTrypanosomiasis, AfricanTsetse FliesConceptsGut lumenCurrent disease control methodsTsetse's PMMidgut environmentTsetse's abilityAbundant secretory proteinsPeritrophic matrixInfection outcomesTrypanosome infection prevalenceChemotherapeutic treatmentParatransgenic manipulationInfected peopleEtiological agentInfection prevalenceInfectionInfection establishmentParasitic African trypanosomesCardiaSignificant increaseNon-coding RNAsPhysiological homeostasisMolecular cascadesBlood digestionSmall non-coding RNAsParatransgenic tsetse
2012
Enhancing tsetse fly refractoriness to trypanosome infection – A new IAEA coordinated research project
Van Den Abbeele J, Bourtzis K, Weiss B, Cordón-Rosales C, Miller W, Abd-alla AM, Parker A. Enhancing tsetse fly refractoriness to trypanosome infection – A new IAEA coordinated research project. Journal Of Invertebrate Pathology 2012, 112: s142-s147. PMID: 22841950, DOI: 10.1016/j.jip.2012.07.020.Peer-Reviewed Original Research
2008
Paratransgenesis Applied for Control of Tsetse Transmitted Sleeping Sickness
Aksoy S, Weiss B, Attardo G. Paratransgenesis Applied for Control of Tsetse Transmitted Sleeping Sickness. Advances In Experimental Medicine And Biology 2008, 627: 35-48. PMID: 18510012, DOI: 10.1007/978-0-387-78225-6_3.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGene Expression RegulationSymbiosisTransgenesTrypanosomiasis, AfricanTsetse FliesConceptsGenetic transformation systemForeign gene productsSodalis symbiontsSymbiotic microbesNew vector control strategiesTsetse symbiontsFunctional biologyTransmission biologyGene productsHost functionsSymbiontsTsetse vectorDisease cycleControl of trypanosomiasisTrypanosome transmissionImmunity effectorsTransformation systemTransformation technologyBiologyGenomicsCurrent knowledgeVector control strategiesAnimal healthTrypanocidal compoundsSleeping Sickness