2021
Human embryo polarization requires PLC signaling to mediate trophectoderm specification
Zhu M, Shahbazi M, Martin A, Zhang C, Sozen B, Borsos M, Mandelbaum RS, Paulson RJ, Mole MA, Esbert M, Titus S, Scott RT, Campbell A, Fishel S, Gradinaru V, Zhao H, Wu K, Chen ZJ, Seli E, de los Santos MJ, Goetz M. Human embryo polarization requires PLC signaling to mediate trophectoderm specification. ELife 2021, 10: e65068. PMID: 34569938, PMCID: PMC8514238, DOI: 10.7554/elife.65068.Peer-Reviewed Original ResearchMeSH KeywordsActinsAdultBody PatterningCell DifferentiationCell LineageCell PolarityEmbryo Culture TechniquesEmbryo, MammalianFemaleGATA3 Transcription FactorGene Expression Regulation, DevelopmentalGene Expression Regulation, EnzymologicHumansPhosphoinositide Phospholipase CPhospholipase C betaPregnancySignal TransductionTime FactorsYoung AdultConceptsApical domain formationInner cell massEmbryo polarizationPhospholipase CFirst lineage segregationApico-basal polarizationEight-cell stageLineage segregationMammalian developmentTrophectoderm specificationTE fateApical enrichmentApical accumulationDistinct lineagesApical domainApolar cellsPar complexPolarized cellsRNA interferenceMolecular mechanismsF-actinHuman embryosCell stageEmbryosDomain formationUnfolded protein response triggers differential apoptotic mechanisms in ovaries and early embryos exposed to maternal type 1 diabetes
Okan A, Demir N, Sozen B. Unfolded protein response triggers differential apoptotic mechanisms in ovaries and early embryos exposed to maternal type 1 diabetes. Scientific Reports 2021, 11: 12759. PMID: 34140543, PMCID: PMC8211688, DOI: 10.1038/s41598-021-92093-3.Peer-Reviewed Original ResearchConceptsUnfolded protein responseProtein responseER stressDiabetes mellitusFemale mammalian reproductive systemEndoplasmic reticulum (ER)-stressMaternal type 1 diabetesEmbryonic developmentActivation of ER stressMammalian ovarian functionType 1 DMIn vivo mouse modelInduced developmental programAdult ovarian tissueEffect of DMMammalian reproductive systemEarly embryonic developmentEarly embryo developmentPre-implantation embryosType 1 diabetesApoptotic cascadeDiabetic ovariesMaternal DMActivated CHOPCaspase 12
2016
The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia
Ozturk S, Sozen B, Uysal F, Bassorgun I, Usta M, Akkoyunlu G, Demir N. The poly(A)-binding protein genes, EPAB, PABPC1, and PABPC3 are differentially expressed in infertile men with non-obstructive azoospermia. Journal Of Assisted Reproduction And Genetics 2016, 33: 335-348. PMID: 26843391, PMCID: PMC4785164, DOI: 10.1007/s10815-016-0654-z.Peer-Reviewed Original ResearchConceptsPoly(A)-binding proteinNon-obstructive azoospermiaPoly(A)-binding protein geneSertoli cell-only syndromeTesticular biopsy samplesRound spermatidsPABP expressionExpression levelsIsolated spermatocytesTranslational controlProtein geneInfertile menPABPC1Male infertilitySpermatocytesPABPC3MRNA expressionArrest groupEPABSco groupBiopsy samplesMolecular backgroundProteinAzoospermiaEvaluate expression levels
2011
CCM2 expression during prenatal development and adult human neocortex
Tanriover G, Sozen B, Gunel M, Demir N. CCM2 expression during prenatal development and adult human neocortex. International Journal Of Developmental Neuroscience 2011, 29: 509-514. PMID: 21569831, DOI: 10.1016/j.ijdevneu.2011.04.006.Peer-Reviewed Original ResearchConceptsAdult human neocortexCerebral cavernous malformationsHuman neocortexNeuroglial precursor cellsPrenatal developmentMeans of immunohistochemistryCentral nervous systemWestern blot analysisHuman brain developmentVascular malformationsAdult neocortexGlial cellsCavernous malformationsCCM lesionsVascular endotheliumNervous systemVascular channelsBlood vessel formationArterial endotheliumBrain developmentNeocortexExpression patternsEndotheliumPrecursor cellsCCM loci