2024
Novel non‐invasive molecular signatures for oral cavity cancer, by whole transcriptome and small non‐coding RNA sequencing analyses: Predicted association with PI3K/AKT/mTOR pathway
Vageli D, Doukas P, Townsend J, Pickering C, Judson B. Novel non‐invasive molecular signatures for oral cavity cancer, by whole transcriptome and small non‐coding RNA sequencing analyses: Predicted association with PI3K/AKT/mTOR pathway. Cancer Medicine 2024, 13: e7309. PMID: 38819439, PMCID: PMC11141334, DOI: 10.1002/cam4.7309.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBiomarkers, TumorCarcinoma, Squamous CellCase-Control StudiesFemaleGene Expression ProfilingGene Expression Regulation, NeoplasticHumansMaleMicroRNAsMiddle AgedMouth NeoplasmsPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktRNA, MessengerRNA, Small UntranslatedSalivaSequence Analysis, RNASignal TransductionTOR Serine-Threonine KinasesTranscriptomeConceptsOral squamous cell carcinomaPost-treatment monitoringHealthy controlsOral cavity cancer patientsOral cavity cancerIdentification of molecular biomarkersSquamous cell carcinomaPatients relative to HCSamples of salivaMonitoring of patientsCell carcinomaPost-treatment monitoring of patientsSmoking historySerum miRNAsCancer patientsEfficient clinical toolEffective preventive careTherapeutic approachesMRNA signatureRNA sequencing analysisClinical testingSerumPatientsMolecular biomarkersClinical tool
2023
Association of Age and Frailty With 30‐Day Outcomes Among Patients Undergoing Oral Cavity Cancer Surgery
Boyi T, Williams L, Kafle S, Roche A, Judson B. Association of Age and Frailty With 30‐Day Outcomes Among Patients Undergoing Oral Cavity Cancer Surgery. Otolaryngology 2023, 169: 1523-1532. PMID: 37595108, DOI: 10.1002/ohn.476.Peer-Reviewed Original ResearchConceptsNational Quality Improvement Program databaseFrailty index scoreAdverse eventsSurgeons National Quality Improvement Program databaseIndex scoreOral cavity cancer surgeryQuality Improvement Program databaseRetrospective cross-sectional analysisHigher mFI scoresPostoperative adverse eventsImprovement Program databaseChronic obstructive diseaseCongestive heart failureFree flap reconstructionAssociation of ageImpact of ageCross-sectional analysisMore comorbiditiesOSCC resectionAnesthesiologists classificationPerioperative outcomesComposite resectionNeck dissectionHeart failureMFI score
2021
Assessing Human Papillomavirus Awareness and the Role of Oropharyngeal Squamous Cell Carcinoma Education on Improving Intention to Vaccinate
Torabi SJ, Su‐Velez B, Kasle DA, Yarbrough WG, St. John M, Judson BL. Assessing Human Papillomavirus Awareness and the Role of Oropharyngeal Squamous Cell Carcinoma Education on Improving Intention to Vaccinate. The Laryngoscope 2021, 132: 528-537. PMID: 34383306, DOI: 10.1002/lary.29805.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAlphapapillomavirusCarcinoma, Squamous CellChildCross-Sectional StudiesFemaleHealth Knowledge, Attitudes, PracticeHumansIntentionMaleMiddle AgedOropharyngeal NeoplasmsPapillomavirus VaccinesPatient Acceptance of Health CarePatient Education as TopicSocioeconomic FactorsSurveys and QuestionnairesUnited StatesYoung AdultConceptsOropharyngeal squamous cell carcinomaHuman papillomavirusCross-sectional surveyHPV's roleRole of HPVSquamous cell carcinomaHuman papillomavirus (HPV) awarenessGeneral population's knowledgeOnline cross-sectional surveyHPV vaccinationCell carcinomaGeneral populationRacial disparitiesU.S. populationPopulation knowledgeBlack individualsMultivariate regressionVaccinationPapillomavirusVaccinatorsProfessional sourcesCarcinomaVaccinePopulationPublic knowledgeA 2020 Update on Public Awareness of Head and Neck Cancers
Torabi SJ, Kasle DA, Su-Velez B, Mehra S, Day TA, Yarbrough WG, St. John M, Judson BL. A 2020 Update on Public Awareness of Head and Neck Cancers. Otolaryngology 2021, 166: 305-312. PMID: 33845657, DOI: 10.1177/01945998211006932.Peer-Reviewed Original ResearchConceptsHuman papillomavirusHPV's roleNeck cancerNeck Cancer Awareness WeekKnowledge of HNCSigns/symptomsFormer tobacco usersCross-sectional surveyFormer smokersOropharyngeal cancerRisk factorsTobacco usersElderly individualsRisk populationsAwareness rateUS populationOlder individualsFuture outreach effortsCancerCausal roleHNCAwareness WeekUS CensusExposureHead
2020
Sequencing of Sclerosing Microcystic Adenocarcinoma Identifies Mutational Burden and Somatic Variants Associated With Tumorigenesis
JIANG R, MARQUEZ J, TOWER JI, JACOBS D, CHEN W, MEHRA S, PRASAD ML, JUDSON BL. Sequencing of Sclerosing Microcystic Adenocarcinoma Identifies Mutational Burden and Somatic Variants Associated With Tumorigenesis. Anticancer Research 2020, 40: 6375-6379. PMID: 33109575, DOI: 10.21873/anticanres.14658.Peer-Reviewed Original ResearchConceptsMicrocystic adnexal carcinomaMutational burdenContext of immunosuppressionOral cavity neoplasiaCases of SMADiagnosis of SMAWhole-exome sequencingPotential molecular mechanismsImmunosuppression therapyNodal diseaseNeck dissectionPsoriatic arthritisResidual tumorAdnexal carcinomaPartial glossectomyTongue massSomatic variantsMicrocystic adenocarcinomaSMA casesExome sequencingGenomic profilesFunction mutationsTumorigenesisBurdenMolecular mechanismsA novel surgeon credentialing and quality assurance process using transoral surgery for oropharyngeal cancer in ECOG-ACRIN Cancer Research Group Trial E3311
Ferris RL, Flamand Y, Holsinger FC, Weinstein GS, Quon H, Mehra R, Garcia JJ, Hinni ML, Gross ND, Sturgis EM, Duvvuri U, Méndez E, Ridge JA, Magnuson JS, Higgins KA, Patel MR, Smith RB, Karakla DW, Kupferman ME, Malone JP, Judson BL, Richmon J, Boyle JO, Bayon R, O'Malley BW, Ozer E, Thomas GR, Koch WM, Bell RB, Saba NF, Li S, Sigurdson ER, Burtness B. A novel surgeon credentialing and quality assurance process using transoral surgery for oropharyngeal cancer in ECOG-ACRIN Cancer Research Group Trial E3311. Oral Oncology 2020, 110: 104797. PMID: 32679405, PMCID: PMC7771718, DOI: 10.1016/j.oraloncology.2020.104797.Peer-Reviewed Original ResearchConceptsOropharyngeal cancerTransoral surgeryOropharyngeal bleedingPositive marginsTransoral resectionGrade III/IVSurgical oncology trialsPost-operative therapySurgical quality assuranceSurgical pathology reportsFinal pathologic marginsMulti-institutional dataPathologic marginsBleeding rateClinical trialsPathology reportsLower incidenceOngoing quality assuranceOncology trialsSurgical expertiseMeticulous evaluationSurgeon expertiseTransoral headPatientsSurgeryAssessing National Utilization Trends and Outcomes of Robotic and Endoscopic Thyroidectomy in the United States
Jacobs D, Torabi SJ, Gibson C, Rahmati R, Mehra S, Judson BL. Assessing National Utilization Trends and Outcomes of Robotic and Endoscopic Thyroidectomy in the United States. Otolaryngology 2020, 163: 947-955. PMID: 32539533, DOI: 10.1177/0194599820927699.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseEndoscopic thyroid surgeryRobotic thyroid surgeryThyroid surgeryOpen surgeryRobotic approachNational utilization trendsUnplanned hospital readmissionMultivariable logistic regressionOutcomes of roboticsPostoperative mortalityWorse morbidityComplication rateHospital readmissionEndoscopic thyroidectomyMortality outcomesPositive marginsSurgical approachNational cohortCancer DatabasePatient outcomesEndoscopic approachRetrospective analysisSurgeryOpen approachOutpatient Otolaryngology in the Era of COVID‐19: A Data‐Driven Analysis of Practice Patterns
Kasle DA, Torabi SJ, Savoca EL, Judson BL, Manes RP. Outpatient Otolaryngology in the Era of COVID‐19: A Data‐Driven Analysis of Practice Patterns. Otolaryngology 2020, 163: 138-144. PMID: 32393101, PMCID: PMC7218354, DOI: 10.1177/0194599820928987.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBetacoronavirusChildChild, PreschoolCoronavirus InfectionsCOVID-19Data AnalysisDisease Transmission, InfectiousFemaleHumansMaleMiddle AgedOtolaryngologistsOtorhinolaryngologic DiseasesOutpatientsPandemicsPneumonia, ViralPractice Patterns, Physicians'Retrospective StudiesSARS-CoV-2TelemedicineUnited StatesYoung AdultConceptsDivision of OtolaryngologyTelehealth visitsOlder adultsHospital policy changesSingle-institution studyCoronavirus disease 2019Quantity of patientsOutpatient otolaryngologyRetrospective reviewAcute carePerson visitsOutpatient appointmentsPractice patternsDisease 2019Week 1Week 3VisitsYoung adultsOtolaryngologyCOVID-19Completion ratesOtolaryngologistsAdultsAssociated increaseTelehealth
2019
Clinical characteristics and treatment‐associated survival of head and neck Ewing sarcoma
Torabi SJ, Izreig S, Kasle DA, Benchetrit L, Salehi PP, Judson BL. Clinical characteristics and treatment‐associated survival of head and neck Ewing sarcoma. The Laryngoscope 2019, 130: 2385-2392. PMID: 31774563, DOI: 10.1002/lary.28412.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseOverall survivalLocal therapyRare malignancySurvival analysisPredictors of OSKaplan-Meier survival analysisNeck Ewing sarcomaDistant metastatic diseaseNon-metastatic diseaseMultivariate Cox regressionTime of diagnosisTime of presentationMulti-modal therapyWorse OSClinical characteristicsMetastatic diseaseImproved survivalPediatric patientsDistant metastasisCox regressionRetrospective studyAnatomic distributionCancer DatabaseOsseous diseaseMargins in Sinonasal Squamous Cell Carcinoma: Predictors, Outcomes, and the Endoscopic Approach
Torabi SJ, Spock T, Cardoso B, Chao J, Morse E, Manes RP, Judson BL. Margins in Sinonasal Squamous Cell Carcinoma: Predictors, Outcomes, and the Endoscopic Approach. The Laryngoscope 2019, 130: e388-e396. PMID: 31755988, DOI: 10.1002/lary.28315.Peer-Reviewed Original ResearchConceptsSinonasal squamous cell carcinomaHigh-volume facilitiesNational Cancer DatabaseSquamous cell carcinomaPositive marginsOverall survivalSurgical approachMargin statusCell carcinomaEthmoid sinusEndoscopic approachMultivariable binary logistic regressionDecreased overall survivalHigher T stageBinary logistic regressionAdditional therapySelect patientsAdult patientsEndoscopic treatmentMultivariable analysisSurgical managementT stageTherapy administrationDifferentiated tumorsOpen surgeryPositive Surgical Margins in Submandibular Malignancies: Facility and Practice Variation
Benchetrit L, Morse E, Judson BL, Mehra S. Positive Surgical Margins in Submandibular Malignancies: Facility and Practice Variation. Otolaryngology 2019, 161: 620-628. PMID: 31159649, DOI: 10.1177/0194599819852094.Peer-Reviewed Original ResearchConceptsPositive margin ratePositive surgical marginsPositive marginsOverall survivalMargin rateSurgical resectionSurgical marginsSubmandibular carcinomaCox proportional hazards regressionMultivariable logistic regression analysisCancer-accredited hospitalsPreoperative diagnostic biopsiesNational Cancer DatabasePrimary surgical resectionAdvanced T stageKaplan-Meier curvesProportional hazards regressionLogistic regression analysisQuality of careCarcinoma histologyRetrospective cohortMargin statusPreoperative biopsyT stageHazards regressionGender disparities in head and neck cancer chemotherapy clinical trials participation and treatment
Benchetrit L, Torabi SJ, Tate JP, Mehra S, Osborn HA, Young MR, Burtness B, Judson BL. Gender disparities in head and neck cancer chemotherapy clinical trials participation and treatment. Oral Oncology 2019, 94: 32-40. PMID: 31178210, DOI: 10.1016/j.oraloncology.2019.05.009.Peer-Reviewed Original ResearchConceptsChemotherapy clinical trialsNational Cancer DatabaseClinical trialsDefinitive radiotherapyChemotherapy administrationNational Comprehensive Cancer Network guidelinesMultivariable logistic regression analysisNeck squamous cell carcinomaEnd Results ProgramSquamous cell carcinomaClinical trial participationLogistic regression analysisGeneral U.S. populationChemotherapy useDefinitive chemoradiotherapyNCCN guidelinesAdult patientsDefinitive treatmentMultivariable analysisNetwork guidelinesResults ProgramCell carcinomaTrial participationCancer DatabaseU.S. patientsClinically node-negative head and neck mucosal melanoma: An analysis of current treatment guidelines & outcomes
Torabi SJ, Benchetrit L, Spock T, Cheraghlou S, Judson BL. Clinically node-negative head and neck mucosal melanoma: An analysis of current treatment guidelines & outcomes. Oral Oncology 2019, 92: 67-76. PMID: 31010627, DOI: 10.1016/j.oraloncology.2019.03.017.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overCombined Modality TherapyDatabases, FactualDisease ManagementFemaleHead and Neck NeoplasmsHumansKaplan-Meier EstimateLymph NodesMaleMelanomaMiddle AgedMucous MembraneNeoplasm StagingPractice Guidelines as TopicPractice Patterns, Physicians'PrognosisProportional Hazards ModelsTreatment OutcomeYoung AdultConceptsElective neck dissectionMajority of patientsSinonasal cavityMM casesNCCN guidelinesNational Comprehensive Cancer Network guidelinesNeck mucosal melanomaNode-negative headNational Cancer DatabaseCurrent treatment guidelinesImproved OSRT utilizationSN patientsNCCN recommendationsNeck dissectionMM patientsMucosal melanomaTreatment guidelinesTreatment patternsNetwork guidelinesCancer DatabaseRetrospective analysisOral cavityPatientsSurvival rateNonsquamous cell laryngeal cancers: Incidence, demographics, care patterns, and effect of surgery
Torabi SJ, Cheraghlou S, Kasle DA, Savoca EL, Judson BL. Nonsquamous cell laryngeal cancers: Incidence, demographics, care patterns, and effect of surgery. The Laryngoscope 2019, 129: 2496-2505. PMID: 30632157, DOI: 10.1002/lary.27785.Peer-Reviewed Original ResearchConceptsEffect of surgeryNon-SCC patientsNeuroendocrine tumorsLaryngeal cancerClinical profileMinor salivary gland tumorsClinical M stageNon-SCC cohortSpecific surgical methodsNational Cancer DatabaseMajority of patientsMajor histological subtypesSalivary gland tumorsAdult patientsImproved survivalTreatment regimenDistant metastasisWorse prognosisHistological subtypesCancer DatabaseLaryngeal carcinomaSurgical methodsRetrospective analysisGland tumorsSurgery
2018
Hypopharyngeal Cancer Treatment Delays: Benchmarks and Survival Association
Morse E, Berson E, Fujiwara R, Judson B, Mehra S. Hypopharyngeal Cancer Treatment Delays: Benchmarks and Survival Association. Otolaryngology 2018, 160: 267-276. PMID: 30324861, DOI: 10.1177/0194599818797605.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedBenchmarkingCarcinoma, Squamous CellChemoradiotherapyCohort StudiesDisease-Free SurvivalFemaleHumansHypopharyngeal NeoplasmsLogistic ModelsMaleMiddle AgedMultivariate AnalysisPrognosisProportional Hazards ModelsRadiotherapy, ConformalRetrospective StudiesRisk AssessmentSurvival AnalysisTime-to-TreatmentTreatment OutcomeConceptsRadiation treatment durationOverall survivalInduction chemotherapyMedian durationConcurrent chemoradiationHypopharyngeal cancerCox proportional hazards regressionNational Cancer DatabaseProportional hazards regressionMultivariable logisticRetrospective cohortTreatment initiationMedicaid insuranceTreatment delayCancer HospitalHazards regressionNonwhite raceCancer DatabaseTreatment endSurvival associationsTreatment durationPatientsChemoradiationChemotherapyTreatment factorsSurvival Outcomes for Induction vs Adjuvant Chemotherapy in Squamous Cell Carcinoma of the Maxillary Sinus
Kuo P, Torabi SJ, Kraus D, Judson BL. Survival Outcomes for Induction vs Adjuvant Chemotherapy in Squamous Cell Carcinoma of the Maxillary Sinus. Otolaryngology 2018, 160: 658-663. PMID: 30296902, DOI: 10.1177/0194599818804777.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseAdjuvant chemotherapyMultivariate Cox regressionInduction chemotherapyLog-rank testMaxillary sinus cancerOverall survivalCox regressionSinus cancerMaxillary sinusUnivariate Kaplan-Meier analysisPoor local control ratesAdvanced maxillary sinus cancerAdjuvant chemotherapy cohortImproved overall survivalLocal control rateMortality hazard ratioKaplan-Meier analysisSquamous cell carcinomaSignificant mortality hazard ratiosSecondary database analysisWarrants further investigationPropensity-score matchingChemotherapy cohortHazard ratioPositive surgical margins in parotid malignancies: Institutional variation and survival association
Morse E, Fujiwara RJT, Judson B, Prasad ML, Mehra S. Positive surgical margins in parotid malignancies: Institutional variation and survival association. The Laryngoscope 2018, 129: 129-137. PMID: 30194762, DOI: 10.1002/lary.27221.Peer-Reviewed Original ResearchConceptsPositive surgical marginsPositive margin rateOverall survivalSurgical marginsHigh-volume facilitiesMargin ratePositive marginsParotid malignanciesMucoepidermoid carcinomaCox proportional hazards regressionOverall positive margin rateLow-grade mucoepidermoid carcinomaNational Cancer DatabaseProportional hazards regressionMultivariable logistic regressionPositive margin statusRetrospective database analysisParotid cancerMargin statusHazards regressionCancer DatabaseSurvival associationsDecreased oddsCystic carcinomaPatientsPatterns of failure in high-metastatic node number human papillomavirus-positive oropharyngeal carcinoma
Lee NCJ, Kelly JR, Park HS, An Y, Judson BL, Burtness BA, Husain ZA. Patterns of failure in high-metastatic node number human papillomavirus-positive oropharyngeal carcinoma. Oral Oncology 2018, 85: 35-39. PMID: 30220317, DOI: 10.1016/j.oraloncology.2018.08.001.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBrachytherapyCarcinoma, Squamous CellCombined Modality TherapyFemaleFollow-Up StudiesHumansLymphatic MetastasisMaleMiddle AgedNeck DissectionNeoplasm MetastasisNeoplasm Recurrence, LocalOropharyngeal NeoplasmsPapillomavirus InfectionsProgression-Free SurvivalProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesSalvage TherapyConceptsProgression-free survivalInvolved lymph nodesDistant metastasisPatterns of failureLocoregional recurrenceLymph nodesHuman papillomavirus-positive oropharyngeal carcinomaMultivariate analysisEdition American Joint CommitteeRate of DMWorse progression-free survivalHigh DM rateDedicated clinical trialsAmerican Joint CommitteeCancer (AJCC) staging systemProportional hazards regressionExternal beam radiationOropharynx cancerFree survivalNeck dissectionOropharyngeal carcinomaOverall survivalDisease recurrenceIntraoperative brachytherapyOPC patients
2017
Thirty‐day morbidity and mortality following otologic/neurotologic surgery: Analysis of the national surgical quality improvement program
Schwam ZG, Michaelides E, Kuo P, Hajek MA, Judson BL, Schutt C. Thirty‐day morbidity and mortality following otologic/neurotologic surgery: Analysis of the national surgical quality improvement program. The Laryngoscope 2017, 128: 1431-1437. PMID: 28940480, DOI: 10.1002/lary.26848.Peer-Reviewed Original ResearchConceptsNational Surgical Quality Improvement ProgramSurgical Quality Improvement ProgramAdverse event ratesQuality Improvement ProgramPostoperative morbidityFunctional statusTumor resectionNeurotologic surgerySurgeons National Surgical Quality Improvement ProgramOpen woundsOverall adverse event rateEvent ratesHigher adverse event ratesThirty-day morbidityPoor functional statusRetrospective cohort studyOverall mortality rateMultivariable logistic regressionImpaired functional statusMastoid proceduresPostoperative mortalityMajor morbidityPostoperative complicationsSignificant comorbiditiesCohort studyComparing 30‐Day Morbidity and Mortality in Pediatric and Adult Otologic Surgery
Schwam ZG, Michaelides E, Schwam JR, Kuo P, Hajek MA, Judson BL, Schutt C. Comparing 30‐Day Morbidity and Mortality in Pediatric and Adult Otologic Surgery. Otolaryngology 2017, 157: 830-836. PMID: 28463634, DOI: 10.1177/0194599817704376.Peer-Reviewed Original ResearchConceptsNational Surgical Quality Improvement ProgramNSQIP PediatricAdverse eventsOtologic surgeryOverall adverse event rateMultivariable logistic regression analysisSurgical Quality Improvement ProgramMost adverse eventsPostoperative adverse eventsAdverse event ratesHigher readmission ratesLow complication rateMulti-institutional databaseLogistic regression analysisQuality Improvement ProgramPediatric otologic surgeryInfectious complicationsPostdischarge complicationsReadmission ratesComplication ratePediatric otolaryngologistsHigher oddsConcurrent proceduresAdult populationOtologic procedures