2018
Tumor necrosis factor alfa and interleukin 1 alfa induced phosphorylation and degradation of inhibitory kappa B alpha are regulated by estradiol in endometrial cells
Arlıer S, Kayışlı Ü, Arıcı A. Tumor necrosis factor alfa and interleukin 1 alfa induced phosphorylation and degradation of inhibitory kappa B alpha are regulated by estradiol in endometrial cells. Journal Of Turkish Society Of Obstetric And Gynecology 2018, 15: 50-59. PMID: 29662717, PMCID: PMC5894537, DOI: 10.4274/tjod.47700.Peer-Reviewed Original ResearchEndometrial cellsNormal endometriumEctopic endometriumInhibitory kappa B-alphaTranscription factor nuclear factor kappa BInhibitory kappa B (IκBα) proteinMonocyte chemoattractant protein-1Ectopic endometrial cellsHomologous eutopic endometriumNuclear factor kappa BCultured endometrial cellsEffects of estradiolNecrosis factor alfaChemoattractant protein-1Human endometrial cellsRegulation of chemokinesTumor necrosis factorFactor kappa BKappa B alphaUterine endometrial cellsEutopic endometriumInflammatory responseNecrosis factorEndometriumKappa B
2005
Immunology of endometriosis.
Ulukus M, Arici A. Immunology of endometriosis. Minerva Obstetrics And Gynecology 2005, 57: 237-48. PMID: 16166933.Peer-Reviewed Original ResearchConceptsPathogenesis of endometriosisEctopic endometrial cellsEndometrial cellsAutoimmune diseasesImmune cellsNatural killer cell cytotoxicityPresence of autoantibodiesKiller cell cytotoxicityReproductive-age womenRetrograde menstruation theoryRetrograde menstruationCellular immunityHumoral immunityUterine cavityEctopic endometriumEndometriotic diseaseAge womenT cellsPeritoneal cavityEnigmatic disorderEndometriosisCell cytotoxicityImpaired capacityPathogenesisStromal cells
2004
Endocrine‐Immune Interactions in Human Endometrium
KAYISLI UA, GUZELOGLU‐KAYISLI O, ARICI A. Endocrine‐Immune Interactions in Human Endometrium. Annals Of The New York Academy Of Sciences 2004, 1034: 50-63. PMID: 15731299, DOI: 10.1196/annals.1335.005.Peer-Reviewed Original ResearchConceptsProtein kinase BEndocrine-immune interactionsHuman endometriumBalanced regulationKinase BCell survivalImmune systemMolecular pathwaysApoptotic moleculesSurvival factorProgression of pregnancyWidespread associationReproductive systemTissue repairIndirect roleMenstrual bleedingApoptosisEndometrial cellsEndometrial differentiationNonresident cellsChemotactic cytokinesLeukocyte recruitmentSex steroidsBlastocyst implantationRegulation
2003
Estrogen regulates MCP-1 in endometrial cells differently in women with endometriosis and may involve a non-genomic pathway
Halis G, Taskiran S, Kayisli U, Arici A. Estrogen regulates MCP-1 in endometrial cells differently in women with endometriosis and may involve a non-genomic pathway. Fertility And Sterility 2003, 80: 33. DOI: 10.1016/s0015-0282(03)01888-0.Peer-Reviewed Original ResearchApoptosis and the Pathogenesis of Endometriosis
Garcia-Velasco J, Arici A. Apoptosis and the Pathogenesis of Endometriosis. Seminars In Reproductive Medicine 2003, 21: 165-172. PMID: 12917786, DOI: 10.1055/s-2003-41323.Peer-Reviewed Original ResearchConceptsPathogenesis of endometriosisEndometrial cellsSex steroid modulationDisease-free womenEutopic endometrial cellsBcl-2/BaxEndometriotic implantsSteroid modulationInflammatory environmentInflammatory reactionAbnormal survivalEndometriosisApoptosis-related genesFas ligandPhysiologic processesEarly eventsPathogenesisApoptosis
2002
Structural Differentiation of Human Uterine Luminal and Glandular Epithelium during Early Pregnancy: An Ultrastructural and Immunohistochemical Study
Demir R, Kayisli U, Celik-Ozenci C, Korgun E, Demir-Weusten A, Arici A. Structural Differentiation of Human Uterine Luminal and Glandular Epithelium during Early Pregnancy: An Ultrastructural and Immunohistochemical Study. Placenta 2002, 23: 672-684. PMID: 12361686, DOI: 10.1053/plac.2002.0841.Peer-Reviewed Original ResearchConceptsGlandular epitheliumEarly pregnancyTrophoblastic invasionEarly gestationClear cellsDark cellsImmunoreactivity of PCNAEpithelial cellsEarly human pregnancyHuman endometrial epitheliumApocrine secretory activityEndothelial marker CD31Luminal epithelial cellsEarly gestation periodCell nuclear antigenHuman pregnancyEndometrial cellsMenstrual cycleImmunohistochemical studyEndometrial epitheliumLuminal epitheliumSurface epitheliumProminent nucleoliPregnancyUterine secretions
2001
Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1
Selam B, Kayisli U, Mulayim N, Arici A. Regulation of Fas Ligand Expression by Estradiol and Progesterone in Human Endometrium1. Biology Of Reproduction 2001, 65: 979-985. PMID: 11566716, DOI: 10.1095/biolreprod65.4.979.Peer-Reviewed Original ResearchConceptsFasL expressionSteroid hormonesEndometrial cellsHuman endometriumMenstrual cycle-dependent expressionGlandular cellsOvarian steroid hormonesSex steroid hormonesEndometrial glandular cellsLate proliferative phaseStrong FasL expressionFas ligand expressionFasL mRNA expressionReverse transcription-polymerase chain reaction analysisTranscription-polymerase chain reaction analysisFasL protein expressionMaternal immunotoleranceWestern blot analysisInteraction of FasLFasL immunoreactivityImplantation windowMenstrual cycleHuman Endometrium1Secretory phaseChain reaction analysisEstradiol fails to down-regulate monocyte chemotactic protein-1 (MCP-1) expression in endometrial cells of women with endometriosis.
Arici A, Bahtiyar M, Seli E, Senturk L. Estradiol fails to down-regulate monocyte chemotactic protein-1 (MCP-1) expression in endometrial cells of women with endometriosis. Fertility And Sterility 2001, 76: s47. DOI: 10.1016/s0015-0282(01)02155-0.Peer-Reviewed Original Research
1999
Progesterone Metabolism in Human Endometrial Stromal and Gland Cells in Culture
Arici A, Marshburn P, MacDonald P, Dombrowski R. Progesterone Metabolism in Human Endometrial Stromal and Gland Cells in Culture. Steroids 1999, 64: 530-534. PMID: 10493598, DOI: 10.1016/s0039-128x(99)00029-x.Peer-Reviewed Original ResearchConceptsMetabolism of progesteroneProgesterone metabolismHuman endometriumCultured endometrial cellsNormal human endometriumEndometrial StromalNormal endometriumProgesterone treatmentEndometrial cellsGland cellsEndometriumProgesteroneAbundant metabolitesMetabolismCell typesCellular fractionsCellsThin-layer chromatographySteroidsStromalMacrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis
Garcia-Velasco J, Arici A, Zreik T, Naftolin F, Mor G. Macrophage derived growth factors m odulate Fas ligand expression in cultured endometrial stromal cells: a role in endometriosis. Molecular Human Reproduction 1999, 5: 642-650. PMID: 10381819, DOI: 10.1093/molehr/5.7.642.Peer-Reviewed Original ResearchMeSH KeywordsCell DifferentiationCells, CulturedChoriocarcinomaCulture Media, ConditionedEndometriumFas Ligand ProteinFemaleFibroblast Growth Factor 2Gene Expression RegulationHumansLeukemia, MyeloidLigandsMacrophagesMembrane GlycoproteinsPlatelet-Derived Growth FactorPregnancyStromal CellsTransforming Growth Factor betaTumor Cells, CulturedUterine NeoplasmsConceptsBasic fibroblast growth factorEndometrial stromal cellsGrowth factorFasL expressionStromal cellsImmune cellsEndometrial cellsCultured endometrial stromal cellsEndometrial stromal cell culturesRegurgitated endometrial cellsImmune privilege statusPro-inflammatory naturePlatelet-derived growth factorMacrophage-conditioned mediumDose-dependent mannerFas ligand expressionFas ligand interactionsFibroblast growth factorStromal cell culturesPeritoneal fluidImmune surveillanceMacrophage productsLigand expressionCertain cell populationsCell populations
1998
Recent advances in endometriosis
Arici A, Pehlivan T. Recent advances in endometriosis. Current Opinion In Endocrinology Diabetes And Obesity 1998, 5: 330-340. DOI: 10.1097/00060793-199811000-00015.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPeritoneal fluidMaximal pain reliefEndometriosis-associated infertilityEffect of endometriosisChemoattractant protein-1Pathogenesis of endometriosisPain reliefPelvic painIL-10Pathophysiologic mechanismsTreatment optionsEctopic endometriumIL-13Endometrial cellsReproductive outcomesAromatase expressionMild lesionsSide effectsFertility outcomesMatrix metalloproteinasesEndometriosisPeritoneal macrophagesApoptosis markersIntegrin expressionProtein 1Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1
Arici A, Seli E, Zeyneloglu H, Senturk L, Oral E, Olive D. Interleukin-8 Induces Proliferation of Endometrial Stromal Cells: a Potential Autocrine Growth Factor1. The Journal Of Clinical Endocrinology & Metabolism 1998, 83: 1201-1205. PMID: 9543141, DOI: 10.1210/jcem.83.4.4743.Peer-Reviewed Original ResearchConceptsEndometrial stromal cellsIL-8 productionInterleukin-8Sex steroid hormonesAutocrine growth factorGrowth factorEndometrial cellsCell proliferationSteroid hormonesStromal cellsEndometrial stromal cell proliferationNeutrophil chemoattractant/Potential autocrine growth factorProliferation of endometriumOligonucleotide treatmentPathogenesis of endometriosisProliferation inhibitory effectPotent angiogenic agentStromal cell proliferationConcentration-dependent inhibitionNumber of cytokinesConcentration-dependent increaseAntisense oligonucleotide treatmentEndometrial functionSpecific growth factorsHOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium.
Taylor H, Arici A, Olive D, Igarashi P. HOXA10 is expressed in response to sex steroids at the time of implantation in the human endometrium. Journal Of Clinical Investigation 1998, 101: 1379-1384. DOI: 10.1172/jci1057.Peer-Reviewed Original ResearchExpression of HOXA10Menstrual cycleTime of implantationSex steroidsCultured endometrial cellsUterine factor infertilityEffects of estrogenFactor infertilityEndometrial developmentEndometrial cellsHuman endometriumMidsecretory phaseHuman uterusPhysiologic rangeProgesteroneHOXA10Targeted disruptionNorthern blot analysisBlot analysisEstrogenSteroidsImplantationSitu hybridizationNovel regulatorExpression
1995
Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium
Arici A, Engin O, Attar E, Olive D. Modulation of leukemia inhibitory factor gene expression and protein biosynthesis in human endometrium. The Journal Of Clinical Endocrinology & Metabolism 1995, 80: 1908-1915. PMID: 7775640, DOI: 10.1210/jcem.80.6.7775640.Peer-Reviewed Original ResearchMeSH KeywordsAdultBloodCells, CulturedCulture MediaDeciduaEndometriumEpidermal Growth FactorFemaleGene Expression RegulationGrowth InhibitorsHumansInterferon-gammaInterleukin-1Interleukin-6Leukemia Inhibitory FactorLymphokinesMiddle AgedPlatelet-Derived Growth FactorPregnancyProtein BiosynthesisRNA, MessengerTransforming Growth Factor betaTumor Necrosis Factor-alphaConceptsExpression of LIFLeukemia inhibitory factorLIF expressionLIF mRNAEndometrial cellsGrowth factorHuman endometriumLeukemia inhibitory factor gene expressionMenstrual cycle-dependent mannerRole of LIFSteroid hormonesHuman implantationLIF mRNA expressionEndometrial stromal cellsEndometrium/deciduaHuman endometrial cellsPlatelet-derived growth factorEndometrial gland cellsMessenger ribonucleic acid levelsRibonucleic acid levelsMidluteal endometriumFactor gene expressionTime-dependent mannerFirst trimesterTumor necrosisRegulation of monocyte chemotactic protein-1 gene expression in human endometrial cells in cultures
Arici A, MacDonald P, Casey M. Regulation of monocyte chemotactic protein-1 gene expression in human endometrial cells in cultures. Molecular And Cellular Endocrinology 1995, 107: 189-197. PMID: 7768330, DOI: 10.1016/0303-7207(94)03442-v.Peer-Reviewed Original ResearchMeSH KeywordsBase SequenceCells, CulturedChemokine CCL2Chemotactic FactorsCulture MediaDeciduaDNA PrimersEndometriumEpithelial CellsEpitheliumFemaleGene Expression RegulationHalf-LifeHumansInterleukin-1Menstrual CycleMolecular Sequence DataPlatelet-Derived Growth FactorPregnancyRNA, MessengerTranscription, GeneticTumor Necrosis Factor-alphaConceptsMCP-1 mRNAMonocyte chemotactic protein-1Endometrial stromal cellsEndometrium/deciduaStromal cellsBone marrow-derived leukocytesHuman endometrial stromal cellsEpithelial cellsChemotactic protein-1 gene expressionDuration of pregnancyChemotactic protein-1Human endometrial tissueMonocyte chemotactic protein-1 gene expressionHuman endometrial cellsHuman endometrium/deciduaDay of cycleProtein-1 gene expressionTotal RNAMacrophage chemotacticTypes of leukocytesEndometrial tissueHormonal milieuDecidua parietalisEndometrial cellsHuman endometrium
1994
Expression of transforming growth factor-β1 messenger ribonucleic acid and the modulation of deoxyribonucleic acid synthesis by transforming growth factor-β1 in human endometrial cells
Marshburn P, Arici A, Casey M. Expression of transforming growth factor-β1 messenger ribonucleic acid and the modulation of deoxyribonucleic acid synthesis by transforming growth factor-β1 in human endometrial cells. American Journal Of Obstetrics And Gynecology 1994, 170: 1152-1158. PMID: 8166201, DOI: 10.1016/s0002-9378(94)70112-1.Peer-Reviewed Original ResearchConceptsEstradiol-17 betaEndometrial stromal cellsEndometrial glandsMessenger ribonucleic acidStromal cellsHuman endometriumDeoxyribonucleic acid synthesisGlandular epitheliumEpithelial cellsEndometrial glandular epitheliumEndometrial cell proliferationStromal cell originHuman endometrial cellsGrowth factor-β1Acid synthesisRibonucleic acidSecretory endometriumEndometrial cellsTrichloroacetic acid-precipitable materialEndometrial epitheliumSecretory phaseFactor-β1Cell originAcid-precipitable materialEndometrium
1993
Regulation of interleukin-8 gene expression in human endometrial cells in culture
Arici A, Head J, MacDonald P, Casey M. Regulation of interleukin-8 gene expression in human endometrial cells in culture. Molecular And Cellular Endocrinology 1993, 94: 195-204. PMID: 8224523, DOI: 10.1016/0303-7207(93)90168-j.Peer-Reviewed Original ResearchConceptsIL-8 mRNAEndometrial stromal cellsIL-1 alphaInterleukin-8 gene expressionEndometrial epithelial cellsStromal cellsEpithelial cellsIL-8 mRNA levelsImmunoreactive IL-8IL-8 gene expressionIL-8 gene transcriptionHuman endometrial cellsRecruitment of leukocytesIL-1 treatmentConcentration-dependent mannerIL-8Endometrial cellsTumor necrosisHuman endometriumGene expressionIL-1Glandular epitheliumSerum-free mediumSerum treatmentPresence of serum