2021
Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface
Lu-Culligan A, Chavan AR, Vijayakumar P, Irshaid L, Courchaine EM, Milano KM, Tang Z, Pope SD, Song E, Vogels CBF, Lu-Culligan WJ, Campbell KH, Casanovas-Massana A, Bermejo S, Toothaker JM, Lee HJ, Liu F, Schulz W, Fournier J, Muenker MC, Moore AJ, Team Y, Konnikova L, Neugebauer KM, Ring A, Grubaugh ND, Ko AI, Morotti R, Guller S, Kliman HJ, Iwasaki A, Farhadian SF. Maternal respiratory SARS-CoV-2 infection in pregnancy is associated with a robust inflammatory response at the maternal-fetal interface. Med 2021, 2: 591-610.e10. PMID: 33969332, PMCID: PMC8084634, DOI: 10.1016/j.medj.2021.04.016.Peer-Reviewed Original ResearchConceptsSARS-CoV-2 infectionMaternal-fetal interfaceACE2 expressionNatural killerPregnant womenPlacental cellsAcute respiratory syndrome coronavirus 2 infectionSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infectionSARS-CoV-2-infected womenTerm placentaSyndrome coronavirus 2 infectionCoronavirus 2 infectionPotential immune mechanismsRobust inflammatory responseRobust immune responseCoronavirus disease 2019Detectable viral RNAInterferon-related genesLower ACE2 expressionMajority of placentasPregnancy complicationsPlacental histologyHofbauer cellsEarly pregnancyImmune activation
2017
Reply to Liu: Inflammation before implantation both in evolution and development
Griffith OW, Chavan AR, Protopapas S, Maziarz J, Romero R, Wagner GP. Reply to Liu: Inflammation before implantation both in evolution and development. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 115: e3-e4. PMID: 29233940, PMCID: PMC5776823, DOI: 10.1073/pnas.1717001115.Peer-Reviewed Original ResearchGenetic Associations with Gestational Duration and Spontaneous Preterm Birth
Zhang G, Feenstra B, Bacelis J, Liu X, Muglia LM, Juodakis J, Miller DE, Litterman N, Jiang PP, Russell L, Hinds DA, Hu Y, Weirauch MT, Chen X, Chavan AR, Wagner GP, Pavličev M, Nnamani MC, Maziarz J, Karjalainen MK, Rämet M, Sengpiel V, Geller D, Boyd HA, Palotie A, Momany A, Bedell B, Ryckman KK, Huusko JM, Forney CR, Kottyan LC, Hallman M, Teramo K, Nohr EA, Davey-Smith G, Melbye M, Jacobsson B, Muglia LJ. Genetic Associations with Gestational Duration and Spontaneous Preterm Birth. New England Journal Of Medicine 2017, 377: 1156-1167. PMID: 28877031, PMCID: PMC5561422, DOI: 10.1056/nejmoa1612665.Peer-Reviewed Original ResearchMeSH KeywordsAdenylyl CyclasesDatasets as TopicFemaleGenetic Predisposition to DiseaseGenetic VariationGenome-Wide Association StudyGestational AgeHumansPeptide Elongation FactorsPhenotypePolymorphism, Single NucleotidePregnancyPremature BirthRas ProteinsReceptor, Angiotensin, Type 2Regression AnalysisTrans-ActivatorsWnt4 ProteinConceptsGestational durationPreterm birthDiscovery setSpontaneous preterm birthDuration of gestationMother-infant dyadsGenomewide association studiesGenetic associationVascular controlMaternal nutritionSignificant genomewide associationEstrogen receptorPossible genetic associationDichotomous outcomesUterine developmentGenetic factorsMechanistic involvementReplication data setsAssociation studiesBirthSuggestive significanceGenomewide significanceAGTR2Replication setAssociationThe inflammation paradox in the evolution of mammalian pregnancy: turning a foe into a friend
Chavan AR, Griffith OW, Wagner GP. The inflammation paradox in the evolution of mammalian pregnancy: turning a foe into a friend. Current Opinion In Genetics & Development 2017, 47: 24-32. PMID: 28850905, DOI: 10.1016/j.gde.2017.08.004.Peer-Reviewed Original ResearchConceptsAdaptive immune systemMammalian pregnancyOutcome of pregnancySemi-allogenic fetusInfluence of inflammationContinuation of pregnancyImmunological paradoxAcute inflammationMaternal healthWorse inflammationEndometrial inflammationVascular permeabilityEmbryo implantationInflammationImmune systemPregnancyMaternal reactionsFetusesImplantationMatrix reorganizationEmbryo implantation evolved from an ancestral inflammatory attachment reaction
Griffith OW, Chavan AR, Protopapas S, Maziarz J, Romero R, Wagner GP. Embryo implantation evolved from an ancestral inflammatory attachment reaction. Proceedings Of The National Academy Of Sciences Of The United States Of America 2017, 114: e6566-e6575. PMID: 28747528, PMCID: PMC5559003, DOI: 10.1073/pnas.1701129114.Peer-Reviewed Original ResearchConceptsTerm pregnancyMaterno-fetal interfaceEGF-like growth factorInflammatory responseImmune responseEmbryo implantationPregnancyGrowth factorMucin 1Molecular changesImplantationKey markersMiceParturitionExhibit expressionMorphological changesHumansOpossumEutherian mammalsUterusImmunohistochemistryTranscriptomic analysisPlacentaImplantation reactionLocalization profilesSingle-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface
Pavličev M, Wagner GP, Chavan AR, Owens K, Maziarz J, Dunn-Fletcher C, Kallapur SG, Muglia L, Jones H. Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface. Genome Research 2017, 27: 349-361. PMID: 28174237, PMCID: PMC5340963, DOI: 10.1101/gr.207597.116.Peer-Reviewed Original ResearchConceptsSingle-cell transcriptomicsG protein-coupled receptorsCell communication networksGene expression profilesReceptor-ligand pairsCell type identificationOrganismal functionInteraction hubTrophoblast cellsGene expressionExpression profilesEndometrial stromal fibroblastsSpecific expressionCell typesInteractomeTranscriptomicsRich resourceCell interactionsPlacental trophoblast cellsDecidual cellsImmune signalsStromal cellsGrowth factorStromal fibroblastsEndometrial stromal cells
2016
The Transcriptomic Evolution of Mammalian Pregnancy: Gene Expression Innovations in Endometrial Stromal Fibroblasts
Kin K, Maziarz J, Chavan AR, Kamat M, Vasudevan S, Birt A, Emera D, Lynch VJ, Ott TL, Pavlicev M, Wagner GP. The Transcriptomic Evolution of Mammalian Pregnancy: Gene Expression Innovations in Endometrial Stromal Fibroblasts. Genome Biology And Evolution 2016, 8: 2459-2473. PMID: 27401177, PMCID: PMC5010902, DOI: 10.1093/gbe/evw168.Peer-Reviewed Original ResearchConceptsEndometrial stromal fibroblastsGene expression changesTherian speciesEutherian lineagesTranscriptome compositionBovine lineageStem lineageNatural selectionStromal fibroblastsTherian mammalsEutherian mammalsKey genesLoss of expressionTranscriptomic evolutionGene expressionExpression changesLatter cell typeGenesLineagesCell typesCell type presentMammalsMammalian pregnancyExpressionTissue invasionWhat was the ancestral function of decidual stromal cells? A model for the evolution of eutherian pregnancy
Chavan AR, Bhullar BA, Wagner GP. What was the ancestral function of decidual stromal cells? A model for the evolution of eutherian pregnancy. Placenta 2016, 40: 40-51. PMID: 27016782, DOI: 10.1016/j.placenta.2016.02.012.Peer-Reviewed Original ResearchConceptsEutherian mammalsDecidual stromal cellsAncestral functionEutherian cladesMajor lineagesStem lineageEutherian pregnancyStromal cellsEutherian speciesStem eutheriansExtended gestationMammalsEutheriansLineagesMaintenance of pregnancyCellsInvasive placentationLaurasiatheriaCladeEuarchontogliresAfrotheriaFetal-maternal interfaceXenarthraDecidual cellsSpecies