2019
Endometrial recognition of pregnancy occurs in the grey short-tailed opossum ( Monodelphis domestica).
Griffith OW, Chavan AR, Pavlicev M, Protopapas S, Callahan R, Maziarz J, Wagner GP. Endometrial recognition of pregnancy occurs in the grey short-tailed opossum ( Monodelphis domestica). Proceedings Of The Royal Society B 2019, 286: 20190691. PMID: 31213185, PMCID: PMC6599997, DOI: 10.1098/rspb.2019.0691.Peer-Reviewed Original ResearchConceptsRecognition of pregnancyGene expression changesProtein level differencesUpregulation of genesOestrous cycleStem lineagePlesiomorphic modeTranscriptional landscapeEutherian mammalsTranscriptional differencesUterus of femalesAmerican marsupialsMost marsupialsExpression changesFetal supportMarsupialsSteroid hormone profilesOpossumGenesEmbryosHuman pregnancyTransporter abundanceHormone profilesMaternal physiologyPregnancy
2018
The mammalian decidual cell evolved from a cellular stress response
Erkenbrack EM, Maziarz JD, Griffith OW, Liang C, Chavan AR, Nnamani MC, Wagner GP. The mammalian decidual cell evolved from a cellular stress response. PLOS Biology 2018, 16: e2005594. PMID: 30142145, PMCID: PMC6108454, DOI: 10.1371/journal.pbio.2005594.Peer-Reviewed Original ResearchConceptsCellular stress responseNovel cell typesStress responseEndometrial stromal fibroblastsCell typesCell type diversityDecidual stromal cellsCore regulatory genesOxidative stress responseDecidual cell typesEvolutionary noveltyPrecursor cell typesEffector genesRegulatory genesEutherian mammalsTranscription factorsOpossum Monodelphis domesticaOrganismal structureType diversityMolecular mechanismsAnimal speciesMonodelphis domesticaGenesStromal cellsSpecies
2016
The Transcriptomic Evolution of Mammalian Pregnancy: Gene Expression Innovations in Endometrial Stromal Fibroblasts
Kin K, Maziarz J, Chavan AR, Kamat M, Vasudevan S, Birt A, Emera D, Lynch VJ, Ott TL, Pavlicev M, Wagner GP. The Transcriptomic Evolution of Mammalian Pregnancy: Gene Expression Innovations in Endometrial Stromal Fibroblasts. Genome Biology And Evolution 2016, 8: 2459-2473. PMID: 27401177, PMCID: PMC5010902, DOI: 10.1093/gbe/evw168.Peer-Reviewed Original ResearchConceptsEndometrial stromal fibroblastsGene expression changesTherian speciesEutherian lineagesTranscriptome compositionBovine lineageStem lineageNatural selectionStromal fibroblastsTherian mammalsEutherian mammalsKey genesLoss of expressionTranscriptomic evolutionGene expressionExpression changesLatter cell typeGenesLineagesCell typesCell type presentMammalsMammalian pregnancyExpressionTissue invasion