2020
Evolution of Embryo Implantation Was Enabled by the Origin of Decidual Stromal Cells in Eutherian Mammals
Chavan AR, Griffith OW, Stadtmauer D, Maziarz J, Pavlicev M, Fishman R, Koren L, Romero R, Wagner GP. Evolution of Embryo Implantation Was Enabled by the Origin of Decidual Stromal Cells in Eutherian Mammals. Molecular Biology And Evolution 2020, 38: 1060-1074. PMID: 33185661, PMCID: PMC7947829, DOI: 10.1093/molbev/msaa274.Peer-Reviewed Original ResearchConceptsEutherian mammalsEutherian lineagesDecidual stromal cellsNovel cell typesStromal cellsInflammatory responseStem lineageEutherian pregnancyCommon ancestorEvolutionary mechanismsExtended gestationMost marsupialsEmbryo attachmentEmbryo implantationMarsupialsLineagesCell typesMammalsMechanistic understandingEutheriansHelper T cellsFetal-maternal interfaceMammalian pregnancyMaternal tissuesNeutrophil recruitment
2016
The fetal-maternal interface of the nine-banded armadillo: endothelial cells of maternal sinus are partially replaced by trophoblast
Chavan AR, Wagner GP. The fetal-maternal interface of the nine-banded armadillo: endothelial cells of maternal sinus are partially replaced by trophoblast. Zoological Letters 2016, 2: 11. PMID: 27284459, PMCID: PMC4899922, DOI: 10.1186/s40851-016-0048-1.Peer-Reviewed Original ResearchMaternal immune systemImmune systemFetal-maternal immune toleranceSemi-allogenic fetusFetal-maternal interfaceVascular endothelial layerUterine connective tissuePresence of leukocytesEndometrial stromaImmune toleranceImmunohistochemical toolsIntervillous spaceUterine tissuePlacental fibrinoidTrophoblast cellsInvasive placentationEndothelial liningMaternal sinusesEndothelial cellsEndothelial layerSinusConnective tissueBlood sinusesMaternal tissuesLuminal sideWhat was the ancestral function of decidual stromal cells? A model for the evolution of eutherian pregnancy
Chavan AR, Bhullar BA, Wagner GP. What was the ancestral function of decidual stromal cells? A model for the evolution of eutherian pregnancy. Placenta 2016, 40: 40-51. PMID: 27016782, DOI: 10.1016/j.placenta.2016.02.012.Peer-Reviewed Original ResearchConceptsEutherian mammalsDecidual stromal cellsAncestral functionEutherian cladesMajor lineagesStem lineageEutherian pregnancyStromal cellsEutherian speciesStem eutheriansExtended gestationMammalsEutheriansLineagesMaintenance of pregnancyCellsInvasive placentationLaurasiatheriaCladeEuarchontogliresAfrotheriaFetal-maternal interfaceXenarthraDecidual cellsSpecies