2023
Application of novel PACS-based informatics platform to identify imaging based predictors of CDKN2A allelic status in glioblastomas
Tillmanns N, Lost J, Tabor J, Vasandani S, Vetsa S, Marianayagam N, Yalcin K, Erson-Omay E, von Reppert M, Jekel L, Merkaj S, Ramakrishnan D, Avesta A, de Oliveira Santo I, Jin L, Huttner A, Bousabarah K, Ikuta I, Lin M, Aneja S, Turowski B, Aboian M, Moliterno J. Application of novel PACS-based informatics platform to identify imaging based predictors of CDKN2A allelic status in glioblastomas. Scientific Reports 2023, 13: 22942. PMID: 38135704, PMCID: PMC10746716, DOI: 10.1038/s41598-023-48918-4.Peer-Reviewed Original ResearchConceptsInformatics platformDeep learning algorithmsImaging featuresCDKN2A alterationsLearning algorithmHeterozygous lossHomozygous deletionLarge datasetsDeep white matter invasionGBM molecular subtypesNew informaticsQualitative imaging biomarkersWhole-exome sequencingQualitative imaging featuresGBM resectionRadiographic evidenceWorse prognosisPACSMolecular subtypesPial invasionImaging biomarkersCDKN2A mutationsAllele statusNoninvasive identificationMagnetic resonance imagesP13.02.A APPLICATION OF NOVEL PACS-BASED INFORMATICS PLATFORM TO IDENTIFY IMAGING BASED PREDICTORS OF CDKN2A ALLELIC STATUS IN GLIOBLASTOMAS
Tillmanns N, Lost J, Tabor J, Vasandani S, Vetsa S, Marianayagam N, Yalcin K, Erson-Omay Z, von Reppert M, Jekel L, Merkaj S, Ramakrishnan D, Avesta A, de Oliveira Santo I, Jin L, Huttner A, Bousabarah K, Ikuta I, Lin M, Aneja S, Turowski B, Aboian M, Moliterno J. P13.02.A APPLICATION OF NOVEL PACS-BASED INFORMATICS PLATFORM TO IDENTIFY IMAGING BASED PREDICTORS OF CDKN2A ALLELIC STATUS IN GLIOBLASTOMAS. Neuro-Oncology 2023, 25: ii100-ii101. PMCID: PMC10489329, DOI: 10.1093/neuonc/noad137.336.Peer-Reviewed Original ResearchImaging featuresPial invasionQualitative imaging biomarkersQualitative imaging featuresWorse prognosisImaging biomarkersCDKN2A mutationsMethods Sixty-nine patientsCDKN2A alterationsHomozygous deletionHeterozygous lossSixty-nine patientsDeep white matterDeep white matter invasionGBM molecular subtypesWhole-exome sequencingNine patientsGBM resectionRadiographic evidenceMolecular subtypesBACKGROUND GliomasWhite matterAllele statusNoninvasive identificationGliomas
2019
Prognostic markers for immunodeficiency-associated primary central nervous system lymphoma
Kaulen LD, Galluzzo D, Hui P, Barbiero F, Karschnia P, Huttner A, Fulbright R, Baehring JM. Prognostic markers for immunodeficiency-associated primary central nervous system lymphoma. Journal Of Neuro-Oncology 2019, 144: 107-115. PMID: 31190317, DOI: 10.1007/s11060-019-03208-w.Peer-Reviewed Original ResearchConceptsPrimary central nervous system lymphomaDiffusion-weighted imaging patternsMagnetic resonance imagingCentral nervous system lymphomaNervous system lymphomaSystem lymphomaPeripheral enhancementDWI patternsPCNSL casesImaging featuresPrognostic markerHuman immunodeficiency virus (HIV) infectionKaplan-Meier survival analysisDiffuse large B-cell lymphomaYale-New Haven HospitalLarge B-cell lymphomaMedian overall survivalImmunodeficiency virus infectionPredictors of survivalSolid organ transplantationImmunoglobulin heavy chain gene rearrangementPeripheral contrast enhancementLog-rank testMajor risk factorHeavy chain gene rearrangement
2017
RARE-05. PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA IN IMMUNOCOMPROMISED HOSTS – A SINGLE INSTITUTION RETROSPECTIVE STUDY (2002-2017)
Kaulen L, Galluzzo D, Hui P, Huttner A, Fulbright R, Baehring J. RARE-05. PRIMARY CENTRAL NERVOUS SYSTEM LYMPHOMA IN IMMUNOCOMPROMISED HOSTS – A SINGLE INSTITUTION RETROSPECTIVE STUDY (2002-2017). Neuro-Oncology 2017, 19: vi212-vi212. PMCID: PMC5692004, DOI: 10.1093/neuonc/nox168.858.Peer-Reviewed Original ResearchPrimary central nervous system lymphomaImmunocompromised hostPrognostic factorsSystem lymphomaPeripheral enhancementAutoimmune disordersImaging featuresCentral nervous system post-transplant lymphoproliferative disorderLong-term immunosuppressive treatmentPost-transplant lymphoproliferative disorderHuman immunodeficiency virus (HIV) infectionSingle-institution retrospective studyCentral nervous system lymphomaKaplan-Meier survival analysisDiffuse large B-cell lymphomaYale-New Haven HospitalLarge B-cell lymphomaOverall median survivalImmunodeficiency virus infectionPredictors of survivalSeverity of comorbiditiesNegative prognostic factorNervous system lymphomaDistinct clinical featuresShorter overall survival
2016
Ectopic intracranial germinoma
Shankar S, Wu X, Kalra VB, Huttner AJ, Malhotra A. Ectopic intracranial germinoma. Journal Of Clinical Neuroscience 2016, 31: 192-195. PMID: 27050919, DOI: 10.1016/j.jocn.2016.02.013.Peer-Reviewed Original ResearchConceptsCorpus callosumParenchymal lesionsNear-total resolutionSmall peripheral cystsCommon imaging featuresExtent of diseaseIntra-axial massAppropriate differential diagnosisEctopic germinomasPituitary infundibulumPeripheral cystsYounger patientsEctopic lesionsPreoperative imagingHistopathological evaluationEctopic massImaging featuresIntracranial diseaseDifferential diagnosisIntracranial germinomaStereotactic biopsyPineal regionRadiation therapyGerminomaLesions