2024
Percutaneous Coronary Revascularization Strategies After Myocardial Infarction A Systematic Review and Network Meta-Analysis
Reddy R, Howard J, Jamil Y, Madhavan M, Nanna M, Lansky A, Leon M, Ahmad Y. Percutaneous Coronary Revascularization Strategies After Myocardial Infarction A Systematic Review and Network Meta-Analysis. Journal Of The American College Of Cardiology 2024, 84: 276-294. PMID: 38986670, DOI: 10.1016/j.jacc.2024.04.051.Peer-Reviewed Original ResearchConceptsRelative riskCardiovascular mortalityMyocardial infarctionMultivessel coronary artery diseaseAll-cause mortalityAdverse cardiac eventsST-segment elevation myocardial infarctionComplete revascularizationCoronary artery diseaseBayesian network meta-analysesMortality reductionA systematic reviewNetwork meta-analysesElevation myocardial infarctionSystematic reviewMeta-analysesCardiac eventsArtery diseasePrimary outcomeNetwork meta-analysisRevascularization strategyMeta-analysisHead-to-head trialsCoronary revascularization strategyAcute kidney injury
2015
Prognostic impact of multivessel versus culprit vessel only percutaneous intervention for patients with multivessel coronary artery disease presenting with acute coronary syndrome.
Hassanin A, Brener SJ, Lansky AJ, Xu K, Stone GW. Prognostic impact of multivessel versus culprit vessel only percutaneous intervention for patients with multivessel coronary artery disease presenting with acute coronary syndrome. EuroIntervention 2015, 11: 293-300. PMID: 25136882, DOI: 10.4244/eijy14m08_05.Peer-Reviewed Original ResearchConceptsMV-percutaneous coronary interventionMajor adverse cardiac eventsPercutaneous coronary interventionAcute coronary syndromeIschaemia-driven revascularisationMyocardial infarctionNSTE-ACSCoronary syndromeMV diseaseOne-year major adverse cardiac eventsPeriprocedural non-Q-wave myocardial infarctionSegment elevation acute coronary syndromesNon-Q-wave myocardial infarctionDeath/myocardial infarctionElevation acute coronary syndromeMultivessel coronary artery diseaseUrgent Intervention Triage StrategyMultivessel percutaneous coronary interventionMV-PCI groupAdverse cardiac eventsAcute renal failureCoronary artery diseaseOne-year ratesClear clinical benefitPropensity score adjustment
2014
Long-Term Outcome of PCI Versus CABG in Insulin and Non–Insulin-Treated Diabetic Patients Results From the FREEDOM Trial
Dangas GD, Farkouh ME, Sleeper LA, Yang M, Schoos MM, Macaya C, Abizaid A, Buller CE, Devlin G, Rodriguez AE, Lansky AJ, Siami FS, Domanski M, Fuster V, Investigators F. Long-Term Outcome of PCI Versus CABG in Insulin and Non–Insulin-Treated Diabetic Patients Results From the FREEDOM Trial. Journal Of The American College Of Cardiology 2014, 64: 1189-1197. PMID: 25236509, DOI: 10.1016/j.jacc.2014.06.1182.Peer-Reviewed Original ResearchConceptsCoronary artery bypass graft surgeryInsulin-treated diabetes mellitusPercutaneous coronary interventionDrug-eluting stentsDeath/stroke/myocardial infarctionStroke/myocardial infarctionNon-ITDM patientsFREEDOM trialMyocardial infarctionClinical outcomesUnderwent coronary artery bypass graft surgeryMajor adverse cardiovascular eventsMultivessel coronary artery diseaseArtery bypass graft surgeryLong-term clinical outcomesEvent ratesCoronary lesion complexityDiabetes mellitus statusIndex revascularization procedureAdverse cardiovascular eventsBypass graft surgeryPrimary composite endpointCoronary artery diseaseBetter clinical outcomesDiabetic patients results
2013
Prognostic Utility of the SYNTAX Score in Patients With Single Versus Multivessel Disease Undergoing Percutaneous Coronary Intervention (from the Acute Catheterization and Urgent Intervention Triage StrategY [ACUITY] Trial)
Caixeta A, Généreux P, Palmerini T, Lansky AJ, Mehran R, Dangas GD, Xu K, Brener SJ, Stone GW. Prognostic Utility of the SYNTAX Score in Patients With Single Versus Multivessel Disease Undergoing Percutaneous Coronary Intervention (from the Acute Catheterization and Urgent Intervention Triage StrategY [ACUITY] Trial). The American Journal Of Cardiology 2013, 113: 203-210. PMID: 24176063, DOI: 10.1016/j.amjcard.2013.08.035.Peer-Reviewed Original ResearchConceptsMultivessel coronary artery diseaseMajor adverse cardiac eventsSingle-vessel diseasePercutaneous coronary interventionSurgery scoreCoronary interventionClinical outcomesMyocardial infarctionRate of MACETaxus drug-eluting stentsCardiac Surgery (SYNTAX) scoreOverall study cohortAdverse cardiac eventsCoronary artery diseaseDrug-eluting stentsACUITY trialMultivessel diseaseSS tertilesAngiographic predictorsSYNTAX scoreCardiac eventsThird tertileArtery diseaseCardiac deathIndependent predictors
2012
Strategies for Multivessel Revascularization in Patients with Diabetes
Farkouh ME, Domanski M, Sleeper LA, Siami FS, Dangas G, Mack M, Yang M, Cohen DJ, Rosenberg Y, Solomon SD, Desai AS, Gersh BJ, Magnuson EA, Lansky A, Boineau R, Weinberger J, Ramanathan K, Sousa JE, Rankin J, Bhargava B, Buse J, Hueb W, Smith CR, Muratov V, Bansilal S, King S, Bertrand M, Fuster V. Strategies for Multivessel Revascularization in Patients with Diabetes. New England Journal Of Medicine 2012, 367: 2375-2384. PMID: 23121323, DOI: 10.1056/nejmoa1211585.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionCoronary artery diseaseMultivessel coronary artery diseaseDrug-eluting stentsCABG groupPCI groupArtery diseaseMyocardial infarctionMedical therapyMean ageAdvanced coronary artery diseaseLow-density lipoprotein cholesterolAggressive medical therapyBenefit of CABGComposite of deathCoronary artery bypassNonfatal myocardial infarctionPatients' mean ageThree-vessel diseaseSystolic blood pressurePrimary outcome measureRate of deathMultivessel revascularizationNonfatal strokeCoronary interventionThe Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease (FREEDOM) trial: Clinical and angiographic profile at study entry
Bansilal S, Farkouh ME, Hueb W, Ogdie M, Dangas G, Lansky AJ, Cohen DJ, Magnuson EA, Ramanathan K, Tanguay JF, Muratov V, Sleeper LA, Domanski M, Bertrand ME, Fuster V. The Future REvascularization Evaluation in patients with Diabetes mellitus: Optimal management of Multivessel disease (FREEDOM) trial: Clinical and angiographic profile at study entry. American Heart Journal 2012, 164: 591-599. PMID: 23067919, PMCID: PMC4536808, DOI: 10.1016/j.ahj.2012.06.012.Peer-Reviewed Original ResearchConceptsMultivessel coronary artery diseasePercutaneous coronary interventionDiabetic patientsFREEDOM trialBaseline characteristicsContemporary coronary artery bypassFuture Revascularization EvaluationMean hemoglobin A1cMean SYNTAX scoreMultivessel Disease (FREEDOM) trialOptimal medical therapyOptimal revascularization strategyCoronary artery bypassRisk factor controlMedian diabetes durationPrior myocardial infarctionSystolic blood pressureCoronary artery diseaseDrug-eluting stentsLow-density lipoproteinAngiographic profileVascular medicationsArtery bypassDiabetes durationSYNTAX score
2010
Surgical Versus Percutaneous Revascularization for Multivessel Disease in Patients With Acute Coronary Syndromes Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) Trial
Ben-Gal Y, Moses JW, Mehran R, Lansky AJ, Weisz G, Nikolsky E, Argenziano M, Williams MR, Colombo A, Aylward PE, Stone GW. Surgical Versus Percutaneous Revascularization for Multivessel Disease in Patients With Acute Coronary Syndromes Analysis From the ACUITY (Acute Catheterization and Urgent Intervention Triage Strategy) Trial. JACC Cardiovascular Interventions 2010, 3: 1059-1067. PMID: 20965465, DOI: 10.1016/j.jcin.2010.06.017.Peer-Reviewed Original ResearchMeSH KeywordsAcute Coronary SyndromeAcute Kidney InjuryAgedAngioplasty, Balloon, CoronaryBlood TransfusionCoronary AngiographyCoronary Artery BypassFemaleHumansKaplan-Meier EstimateLogistic ModelsMaleMiddle AgedMyocardial InfarctionPlatelet Aggregation InhibitorsPropensity ScoreRecurrenceRisk AssessmentRisk FactorsStrokeTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionAcute coronary syndromeHigh-risk patientsMultivessel diseaseACUITY trialRenal injuryMyocardial infarctionHigh-risk acute coronary syndromesAcute Coronary Syndromes AnalysisHigh-risk ACS patientsMultivessel coronary artery diseasePeri-procedural strokePreferred revascularization strategyPropensity-matched comparisonPropensity-matched patientsAcute renal injuryCoronary artery bypassOutcomes of patientsMore blood transfusionsCoronary artery diseaseRepeat revascularization proceduresACS patientsMajor bleedingPCI groupUnplanned revascularization
2009
Treatment of left main and multivessel disease in the drug-eluting stent era.
Ng VG, Lansky AJ. Treatment of left main and multivessel disease in the drug-eluting stent era. Reviews In Cardiovascular Medicine 2009, 10 Suppl 2: s24-33. PMID: 19898278, DOI: 10.3909/ricm10s20004.Peer-Reviewed Original ResearchConceptsDrug-eluting stentsBypass surgeryMultivessel coronary artery diseaseCoronary artery bypass surgeryDrug-eluting stent eraArtery bypass surgeryHigh-risk patientsPercutaneous coronary interventionCoronary artery diseaseSignificant survival advantageAlternative treatment modalityStandard of careBare metal stentsMultivessel diseaseRepeat revascularizationCoronary interventionArtery diseaseMedical managementStent eraBalloon angioplastyNonrandomized studyLabel useTreatment modalitiesInvasive strategyClinical trials
2007
Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction
Sorajja P, Gersh BJ, Cox DA, McLaughlin MG, Zimetbaum P, Costantini C, Stuckey T, Tcheng JE, Mehran R, Lansky AJ, Grines CL, Stone GW. Impact of multivessel disease on reperfusion success and clinical outcomes in patients undergoing primary percutaneous coronary intervention for acute myocardial infarction. European Heart Journal 2007, 28: 1709-1716. PMID: 17556348, DOI: 10.1093/eurheartj/ehm184.Peer-Reviewed Original ResearchConceptsPrimary PCIPrimary percutaneous coronary interventionMajor adverse cardiac eventsAcute myocardial infarctionCoronary artery diseaseTriple vessel diseasePercutaneous coronary interventionMultivessel diseaseST-segment recoveryReperfusion successCoronary interventionClinical outcomesMyocardial blushMyocardial infarctionPost-procedural TIMI 3 flowExtent of CADExtensive coronary artery diseaseMultivessel coronary artery diseaseAdverse cardiac eventsTIMI 3 flowInfarct-related arterySingle-vessel diseaseCADILLAC trialPost-PCIInfarct vessel