2024
Efficacy and utility of antifibrinolytics in pediatric spine surgery: a systematic review and network meta-analysis
Aghajanian S, Mohammadifard F, Kohandel Gargari O, Naeimi A, Bahadorimonfared A, Elsamadicy A. Efficacy and utility of antifibrinolytics in pediatric spine surgery: a systematic review and network meta-analysis. Neurosurgical Review 2024, 47: 177. PMID: 38644447, DOI: 10.1007/s10143-024-02424-x.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAntifibrinolytic AgentsBlood Loss, SurgicalBlood TransfusionChildHumansNetwork Meta-AnalysisNeurosurgical ProceduresSpineTranexamic AcidTreatment OutcomeConceptsNetwork meta-analysisRate of complicationsBlood lossSpine surgeryEpsilon-aminocaproic acidMeta-analysisTranexamic acidEfficacy of antifibrinolyticsPediatric spine surgeryPerioperative blood lossReduce blood lossStandardized outcome dataRandomized clinical trialsStandard of carePerioperative bleedingTransfusion volumeTransfusion rateAntifibrinolytic agentsMassive transfusionPediatric patientsSafety profilePediatric surgeryProbability of efficacyAntifibrinolyticsClinical trials
2023
Treatment of intramedullary spinal cord tumors: a modified Delphi technique of the North American Spine Society Section of Spine Oncology.
Hersh A, Pennington Z, Lubelski D, Elsamadicy A, Dea N, Desai A, Gokaslan Z, Goodwin C, Hsu W, Jallo G, Krishnaney A, Laufer I, Lo S, Macki M, Mehta A, Ozturk A, Shin J, Soliman H, Sciubba D. Treatment of intramedullary spinal cord tumors: a modified Delphi technique of the North American Spine Society Section of Spine Oncology. Journal Of Neurosurgery Spine 2023, 40: 1-10. PMID: 37856379, DOI: 10.3171/2023.8.spine23190.Peer-Reviewed Original ResearchMeSH KeywordsDelphi TechniqueHumansHypesthesiaNeurosurgical ProceduresNorth AmericaSpinal Cord DiseasesSpinal Cord NeoplasmsTreatment OutcomeConceptsIntramedullary spinal cord tumorsSpinal cord tumorsTumor-specific characteristicsOperative candidacyCord tumorsResection strategyNew neurological deficitsGross total resectionT2 signal changeSet of patientsAreas of controversyIMSCT resectionFrail patientsChronic myelopathyChronic paraplegiaNeurological deficitsPreoperative symptomsTranscranial motorDelphi techniqueSurgical managementMild numbnessOperative managementSurgical interventionFurther resectionRare tumorAcademic career progression in AANS/CNS Spine Section award recipients
Elsamadicy A, Sherman J, Craft S, Virk M, Elder B, Bonfield C, Snyder L, Ray W, Jones K, Ryu W. Academic career progression in AANS/CNS Spine Section award recipients. Journal Of Neurosurgery Spine 2023, 1-8. DOI: 10.3171/2023.7.spine23259.Peer-Reviewed Original ResearchMeSH KeywordsAwards and PrizesBiomedical ResearchFemaleHumansMaleNeurosurgeonsNeurosurgeryNeurosurgical ProceduresUnited StatesConceptsAcademic medical centerPeer-reviewed journalsMedical CenterPeer-reviewed publicationsMean numberPrincipal investigatorMean h-indexAANS/CNS SectionNational InstituteFederal research fundingPeripheral nervesCNS SectionSpine surgeryOutstanding abstractsPrior recipientsMedical Research ProgramSubspecialty focusHealth fundingRecipientsAppointment statusNeurological SurgeonsPublication rateOne-thirdFaculty appointmentsProgressionPromoting diversity in neurosurgery through a virtual symposium.
Charles A, Seas A, Corley J, Duvall J, Owolo E, Abu-Bonsrah N, Elsamadicy A, Simpson V, Sanusi O, Holly L, Rodriguez A, Nduom E, Levi A, Liau L, Quiñones-Hinojosa A, Karikari I, Grant G, Fuller A, Goodwin C. Promoting diversity in neurosurgery through a virtual symposium. Journal Of Neurosurgery 2023, 139: 1101-1108. PMID: 36905659, DOI: 10.3171/2023.1.jns221743.Peer-Reviewed Original Research
2022
Predictors of survival and time to progression following operative management of intramedullary spinal cord astrocytomas
Hersh AM, Antar A, Pennington Z, Aygun N, Patel J, Goldsborough E, Porras JL, Elsamadicy AA, Lubelski D, Wolinsky JP, Jallo GI, Gokaslan ZL, Lo SL, Sciubba DM. Predictors of survival and time to progression following operative management of intramedullary spinal cord astrocytomas. Journal Of Neuro-Oncology 2022, 158: 117-127. PMID: 35538385, DOI: 10.1007/s11060-022-04017-4.Peer-Reviewed Original ResearchMeSH KeywordsAstrocytomaHumansNeurosurgical ProceduresProgression-Free SurvivalRetrospective StudiesSpinal Cord NeoplasmsTreatment OutcomeConceptsProgression-free survivalPredictors of survivalHigh tumor gradeResection extentTumor gradePoor survivalIntramedullary spinal cord astrocytomasPost-operative neurologic deficitsSingle comprehensive cancer centerTumor progression/recurrencePre-operative presentationPreoperative back painSpinal cord astrocytomasKaplan-Meier curvesProgression/recurrenceStandard of careComprehensive cancer centerLong-term survivalPurposeSurgical resectionBowel dysfunctionChemotherapy regimensNeurologic deficitsIntramedullary astrocytomasPatient demographicsComplete resection
2021
Race Is an Independent Predictor for Nonroutine Discharges After Spine Surgery for Spinal Intradural/Cord Tumors
Elsamadicy AA, Koo AB, David WB, Reeves BC, Freedman IG, Pennington Z, Ehresman J, Kolb L, Laurans M, Shin JH, Sciubba DM. Race Is an Independent Predictor for Nonroutine Discharges After Spine Surgery for Spinal Intradural/Cord Tumors. World Neurosurgery 2021, 151: e707-e717. PMID: 33940256, DOI: 10.1016/j.wneu.2021.04.085.Peer-Reviewed Original ResearchConceptsNonroutine discharge dispositionIndependent predictorsNonroutine dischargeDischarge dispositionCord tumorsAA raceSurgical interventionNational Inpatient Sample databaseMultivariable logistic regression analysisStepwise multivariable logistic regression analysisBackward stepwise multivariable logistic regression analysisAfrican AmericansPostoperative complication rateRetrospective cohort studyClinical Modification diagnosisLength of hospitalizationProcedural Coding SystemLogistic regression analysisHealth care costsRegression analysisMultivariate regression analysisAA/BlackPostoperative complicationsCohort studyComplication rate
2020
Thirty- and 90-day Readmissions After Spinal Surgery for Spine Metastases
Elsamadicy AA, Koo AB, David WB, Zogg CK, Kundishora AJ, Hong CS, Kuzmik GA, Gorrepati R, Coutinho PO, Kolb L, Laurans M, Abbed K. Thirty- and 90-day Readmissions After Spinal Surgery for Spine Metastases. Spine 2020, 46: 828-835. PMID: 33394977, PMCID: PMC8278805, DOI: 10.1097/brs.0000000000003907.Peer-Reviewed Original ResearchMeSH KeywordsHumansNeurosurgical ProceduresPatient ReadmissionPostoperative ComplicationsRetrospective StudiesSpineConceptsSpine metastasesGenitourinary complicationsPostoperative infectionSpine surgeryRheumatoid arthritis/collagen vascular diseasesAcute post-hemorrhagic anemiaCollagen vascular diseaseRetrospective cohort studyUnplanned hospital readmissionNationwide Readmissions DatabasePatient-level factorsVulnerable patient groupSurgical treatment interventionMultivariate regression analysisFusion spine surgeryInpatient complicationsFrequent readmissionsUnplanned readmissionCohort studyRenal failureClinical factorsHospital readmissionSurgery typePatient groupVascular diseaseLaser Interstitial Thermotherapy for Treatment of Symptomatic Peritumoral Edema After Radiosurgery for Meningioma
Hong CS, Beckta JM, Kundishora AJ, Elsamadicy AA, Chiang VL. Laser Interstitial Thermotherapy for Treatment of Symptomatic Peritumoral Edema After Radiosurgery for Meningioma. World Neurosurgery 2020, 136: 295-300. PMID: 32001396, DOI: 10.1016/j.wneu.2020.01.143.Peer-Reviewed Original ResearchConceptsSymptomatic peritumoral edemaPeritumoral edemaLaser interstitial thermotherapySurgical resectionGrade IOpen surgical resectionEffective therapeutic modalityViable alternative treatmentInterstitial thermotherapyExperienced resolutionCorticosteroid therapyIntraoperative biopsyRefractory casesConservative managementMost patientsLesion recurrenceMedical therapyRadiation necrosisUnderlying lesionSurgical interventionWound infectionTherapeutic modalitiesRadiosurgical treatmentAlternative treatmentFrontotemporal lesions
2019
In Reply: Institutional Review of Mortality in 5434 Consecutive Neurosurgery Patients: Are We Improving?
Elsamadicy AA, Gottfried ON. In Reply: Institutional Review of Mortality in 5434 Consecutive Neurosurgery Patients: Are We Improving? Neurosurgery 2019, 85: e164-e164. PMID: 31197349, DOI: 10.1093/neuros/nyz110.Peer-Reviewed Original Research
2018
Independent Associations With 30- and 90-Day Unplanned Readmissions After Elective Lumbar Spine Surgery: A National Trend Analysis of 144 123 Patients.
Elsamadicy AA, Ren X, Kemeny H, Charalambous L, Sergesketter AR, Rahimpour S, Williamson T, Goodwin CR, Abd-El-Barr MM, Gottfried ON, Xie J, Lad SP. Independent Associations With 30- and 90-Day Unplanned Readmissions After Elective Lumbar Spine Surgery: A National Trend Analysis of 144 123 Patients. Neurosurgery 2018, 84: 758-767. PMID: 29893899, DOI: 10.1093/neuros/nyy215.Peer-Reviewed Original ResearchConceptsElective lumbar spine surgeryChronic obstructive pulmonary disorderLumbar spine surgeryNational Readmission DatabaseUnplanned hospital readmissionPatient risk factorsUnplanned readmissionHospital readmissionSpine surgeryDeficiency anemiaInsurance statusRisk factorsElective spinal surgeryUnplanned readmission rateObstructive pulmonary disorderMultivariate regression analysisPaucity of dataInpatient complicationsNational healthcare expendituresReadmission ratesDural tearPulmonary disordersIndependent associationPatient outcomesSpinal surgeryInterdisciplinary Care Model Independently Decreases Use of Critical Care Services After Corrective Surgery for Adult Degenerative Scoliosis
Adogwa O, Elsamadicy AA, Sergesketter AR, Ongele M, Vuong V, Khalid S, Moreno J, Cheng J, Karikari IO, Bagley CA. Interdisciplinary Care Model Independently Decreases Use of Critical Care Services After Corrective Surgery for Adult Degenerative Scoliosis. World Neurosurgery 2018, 111: e845-e849. PMID: 29317368, DOI: 10.1016/j.wneu.2017.12.180.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCase ManagementClinical ProtocolsCohort StudiesCritical CareDecompression, SurgicalFemaleGeriatricsHumansLumbar VertebraeMaleNeurosurgical ProceduresPatient Care TeamPostoperative CarePostoperative ComplicationsRetrospective StudiesScoliosisSpinal FusionTreatment OutcomeConceptsElderly patientsCritical care servicesICU transferIndependent predictorsCorrective surgeryFusion surgeryComanagement modelSpine surgeryCare servicesComplex lumbar spine surgeryTeam approachIntensive care unit resourcesPeri-operative optimizationSenior Health (POSH) programDuration of surgeryLumbar spine surgeryInterdisciplinary care modelLong-term outcomesLumbar fusion surgeryMajor academic medical centerAdult degenerative scoliosisAcademic medical centerInterdisciplinary team approachPOSH cohortHospital course
2017
Institutional Review of Mortality in 5434 Consecutive Neurosurgery Patients: Are We Improving?
Elsamadicy AA, Sergesketter A, Sampson JH, Gottfried ON. Institutional Review of Mortality in 5434 Consecutive Neurosurgery Patients: Are We Improving? Neurosurgery 2017, 83: 1269-1276. PMID: 29300938, DOI: 10.1093/neuros/nyx603.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesHumansMaleNeurosurgeryNeurosurgical ProceduresQuality ImprovementQuality Indicators, Health CareConceptsRisk of mortalityCase mix indexSeverity of illnessPostintervention cohortMortality indexQuality InitiativeNeurosurgical serviceDiagnosis-related group codesPre-intervention cohortQuality improvement interventionsEtiology of mortalityHigher case mix indexMajor academic institutionHospital dischargeInpatient mortalityTrauma admissionsNeurosurgery patientsProcedure typeMortality casesInstitutional reviewImprovement interventionsMortalityCohortNeurosurgery inpatientsObserved mortalityGeriatric comanagement reduces perioperative complications and shortens duration of hospital stay after lumbar spine surgery: a prospective single-institution experience.
Adogwa O, Elsamadicy AA, Vuong VD, Moreno J, Cheng J, Karikari IO, Bagley CA. Geriatric comanagement reduces perioperative complications and shortens duration of hospital stay after lumbar spine surgery: a prospective single-institution experience. Journal Of Neurosurgery Spine 2017, 27: 670-675. PMID: 28960161, DOI: 10.3171/2017.5.spine17199.Peer-Reviewed Original ResearchConceptsLumbar spine surgeryHospital stayPOSH cohortElderly patientsSpine surgeryGeriatric comanagementPerioperative complicationsComplex lumbar spine surgeryElective lumbar spine surgeryMedical comorbid conditionsSenior Health (POSH) programDays of dischargeElective spinal surgerySingle institution experienceMajority of patientsNursing home admissionLumbar fusion surgeryResults One hundred twentyMajor academic medical centerAdult degenerative scoliosisAcademic medical centerHospital complicationsSurgical screeningPostoperative complicationsBaseline characteristicsLong-term Cost Utility of Spinal Cord Stimulation in Patients with Failed Back Surgery Syndrome.
Farber SH, Han JL, Elsamadicy AA, Hussaini Q, Yang S, Pagadala P, Parente B, Xie J, Lad SP. Long-term Cost Utility of Spinal Cord Stimulation in Patients with Failed Back Surgery Syndrome. Pain Physician 2017, 20: e797-e805. PMID: 28934786, PMCID: PMC8358894, DOI: 10.36076/ppj.20.5.e797.Peer-Reviewed Original ResearchConceptsConventional medical managementSpinal cord stimulationFBSS patientsSurgery syndromeCord stimulationSCS systemCost utilityFailed Back Surgery SyndromeBack surgery syndromePrior back surgeryGEE modelHealth care utilizationRandomized clinical trialsConventional managementLongitudinal GEE modelsTime of implantationLeg painSCS implantationBack painCare utilizationLong followMedical managementSignificant morbidityBack surgeryTreatment optionsRelationship Among Koenig Depression Scale and Postoperative Outcomes, Ambulation, and Perception of Pain in Elderly Patients (≥65 Years) Undergoing Elective Spinal Surgery for Adult Scoliosis
Adogwa O, Elsamadicy AA, Sergesketter AR, Black C, Tarnasky A, Ongele MO, Vuong VD, Khalid S, Cheng J, Bagley CA, Karikari IO. Relationship Among Koenig Depression Scale and Postoperative Outcomes, Ambulation, and Perception of Pain in Elderly Patients (≥65 Years) Undergoing Elective Spinal Surgery for Adult Scoliosis. World Neurosurgery 2017, 107: 471-476. PMID: 28826716, DOI: 10.1016/j.wneu.2017.07.165.Peer-Reviewed Original ResearchConceptsElective spinal surgeryAmbulation abilityElderly patientsHospital dischargeComplication rateHospital stayPostoperative outcomesVAS scoresSpinal surgeryDepression ScaleVisual analog scale scoreSignificant differencesElective spine surgeryInferior postoperative outcomesPreoperative gait speedAnalog scale scoreDepressed elderly patientsPatient-reported outcomesAdult degenerative scoliosisPerception of painBoard-certified geriatriciansPostoperative complicationsBaseline demographicsIntraoperative variablesPrimary outcomePost-operative delirium is an independent predictor of 30-day hospital readmission after spine surgery in the elderly (≥65years old): A study of 453 consecutive elderly spine surgery patients
Elsamadicy AA, Wang TY, Back AG, Lydon E, Reddy GB, Karikari IO, Gottfried ON. Post-operative delirium is an independent predictor of 30-day hospital readmission after spine surgery in the elderly (≥65years old): A study of 453 consecutive elderly spine surgery patients. Journal Of Clinical Neuroscience 2017, 41: 128-131. PMID: 28262398, DOI: 10.1016/j.jocn.2017.02.040.Peer-Reviewed Original ResearchConceptsPost-operative deliriumIndependent risk factorSpine surgeryElderly patientsReadmission ratesHospital readmissionRisk factorsDelirium patientsComplication rateIndependent predictorsPost-operative complication rateSuperficial surgical site infectionMultivariate logistic regression analysisDuke University Medical CenterConsecutive elderly patientsSpine surgery patientsSurgical site infectionLogistic regression analysisUniversity Medical CenterLower healthcare costsDSM-V criteriaHospital stayUnplanned readmissionPatient demographicsSurgery patients