YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes
Gao Y, Sun Y, Ercan-Sencicek AG, King JS, Akerberg BN, Ma Q, Kontaridis MI, Pu WT, Lin Z. YAP/TEAD1 Complex Is a Default Repressor of Cardiac Toll-Like Receptor Genes. International Journal Of Molecular Sciences 2021, 22: 6649. PMID: 34206257, PMCID: PMC8268263, DOI: 10.3390/ijms22136649.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAge FactorsAnimalsCytokinesDNA-Binding ProteinsGene Expression RegulationImmunity, InnateLipopolysaccharidesMiceMice, Inbred C57BLMyocytes, CardiacSignal TransductionTEA Domain Transcription FactorsToll-Like ReceptorsTranscription FactorsYAP-Signaling ProteinsConceptsToll-like receptorsPattern recognition receptorsTLR genesPro-inflammatory cytokinesPathological stressTLR gene expressionToll-like receptor genesInnate immune responseExpression levelsHeart diseaseImmune responseHippo-YAP signalingRecognition receptorsMouse heartsYAP depletionLuciferase reporter dataReceptor geneTerminal effectorAgeReceptorsHomeostasis maintenanceMolecular mechanismsHeartExpressionExpression patterns