2024
Correlations of Socioeconomic and Clinical Determinants with United States County‐Level Stroke Prevalence
Stulberg E, Lisabeth L, Schneider A, Skolarus L, Kershaw K, Zheutlin A, Harris B, Sarpong D, Wong K, Sheth K, de Havenon A. Correlations of Socioeconomic and Clinical Determinants with United States County‐Level Stroke Prevalence. Annals Of Neurology 2024, 96: 739-744. PMID: 39056317, DOI: 10.1002/ana.27039.Peer-Reviewed Original ResearchSocioeconomic statusStroke prevalenceCounty-level socioeconomic statusSocioeconomic status measuresHealth care accessCenters for Disease Control and PreventionRisk factor measurementsDisease Control and PreventionPrevalence of adultsFederal poverty levelControl and PreventionCare accessStroke metricsStroke riskPoverty levelObservational researchPrevalenceClinical determinantsCommunity estimatesEcological studiesStrokeFactor measurementsHealthInterventionAdultsAntithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study
Yaghi S, Shu L, Mandel D, Guerrero C, Henninger N, Muppa J, Affan M, Lodhi O, Heldner M, Antonenko K, Seiffge D, Arnold M, Omran S, Crandall R, Lester E, Mena D, Arauz A, Nehme A, Boulanger M, Touze E, Sousa J, Sargento-Freitas J, Barata V, Castro-Chaves P, Brito M, Khan M, Mallick D, Rothstein A, Khazaal O, Kaufmann J, Engelter S, Traenka C, de Sousa D, Soares M, Rosa S, Zhou L, Gandhi P, Field T, Mancini S, Metanis I, Leker R, Pan K, Dantu V, Baumgartner K, Burton T, Von Rennenberg R, Nolte C, Choi R, MacDonald J, Shahripour R, Guo X, Ghannam M, AlMajali M, Samaniego E, Sanchez S, Rioux B, Zine-Eddine F, Poppe A, Fonseca A, Baptista M, Cruz D, Romoli M, De Marco G, Longoni M, Keser Z, Griffin K, Kuohn L, Frontera J, Amar J, Giles J, Zedde M, Pascarella R, Grisendi I, Nzwalo H, Liebeskind D, Molaie A, Cavalier A, Kam W, Mac Grory B, Al Kasab S, Anadani M, Kicielinski K, Eltatawy A, Chervak L, Chulluncuy-Rivas R, Aziz Y, Bakradze E, Tran T, Rodrigo-Gisbert M, Requena M, Velez F, Gracia J, Mudassani V, de Havenon A, Vishnu V, Yaddanapudi S, Adams L, Browngoehl A, Ranasinghe T, Dunston R, Lynch Z, Penckofer M, Siegler J, Mayer S, Willey J, Zubair A, Cheng Y, Sharma R, Marto J, Ferreira V, Klein P, Nguyen T, Asad S, Sarwat Z, Balabhadra A, Patel S, Secchi T, Martins S, Mantovani G, Kim Y, Krishnaiah B, Elangovan C, Lingam S, Quereshi A, Fridman S, Alvarado A, Khasiyev F, Linares G, Mannino M, Terruso V, Vassilopoulou S, Tentolouris V, Martinez-Marino M, Wall V, Indraswari F, Jamal S, Liu S, Alvi M, Ali F, Sarvath M, Morsi R, Kass-Hout T, Shi F, Zhang J, Sokhi D, Said J, Simpkins A, Gomez R, Sen S, Ghani M, Elnazeir M, Xiao H, Kala N, Khan F, Stretz C, Mohammadzadeh N, Goldstein E, Furie K. Antithrombotic Treatment for Stroke Prevention in Cervical Artery Dissection: The STOP-CAD Study. Stroke 2024, 55: 908-918. PMID: 38335240, DOI: 10.1161/strokeaha.123.045731.Peer-Reviewed Original ResearchCervical artery dissectionInverse probability of treatment weightingIschemic stroke riskIschemic strokeAntiplatelet therapyArtery dissectionCox regressionOcclusive dissectionCervical artery dissection patientsStroke riskProbability of treatment weightingBenefits of anticoagulationOptimal stroke prevention strategyStroke prevention strategiesReducing ischemic stroke riskAnticoagulant therapyAntithrombotic treatmentProspective studyCross-over approachRandomized trialsAnticoagulationCompare outcomesPrevention strategiesTreatment weightingHigh riskEmergent Large Vessel Occlusion due to Intracranial Stenosis: Identification, Management, Challenges, and Future Directions
Al Kasab S, Nguyen T, Derdeyn C, Yaghi S, Amin-Hanjani S, Kicielinski K, Zaidat O, de Havenon A. Emergent Large Vessel Occlusion due to Intracranial Stenosis: Identification, Management, Challenges, and Future Directions. Stroke 2024, 55: 355-365. PMID: 38252763, DOI: 10.1161/strokeaha.123.043635.Peer-Reviewed Original ResearchConceptsIntracranial atherosclerotic stenosisVessel occlusionRecurrence riskEarly recurrence riskHigh-risk patientsAggressive medical managementRecurrent stroke riskEndovascular therapyHemodynamic failureTreatment strategiesPerfusion imagingAdvanced ageEndovascular interventionIntracranial stenosisMedical managementRisk factorsHigh riskAdvanced imagingAtherosclerotic stenosisStroke riskOcclusionStenosisPatientsRisk
2023
Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses
Renedo D, Acosta J, Koo A, Rivier C, Sujijantarat N, de Havenon A, Sharma R, Gill T, Sheth K, Falcone G, Matouk C. Higher Hospital Frailty Risk Score Is Associated With Increased Risk of Stroke: Observational and Genetic Analyses. Stroke 2023, 54: 1538-1547. PMID: 37216451, PMCID: PMC10212531, DOI: 10.1161/strokeaha.122.041891.Peer-Reviewed Original ResearchConceptsHospital Frailty Risk ScoreRisk of strokeHighest Hospital Frailty Risk ScoresDate of consentFrailty Risk ScoreMendelian randomization analysisStroke riskRisk scoreRandomization analysisTime of enrollmentAvailable electronic health recordsMendelian randomizationElectronic health recordsLook-back periodIncident strokeDose-response wayFrailty statusHemorrhagic strokeMultivariable analysisStroke eventsObservational studyHigh riskFrailtySignificant associationSimilar associationSecondary Ischemic Stroke Prevention
Bangad A, Abbasi M, de Havenon A. Secondary Ischemic Stroke Prevention. Neurotherapeutics 2023, 20: 721-731. PMID: 36877331, PMCID: PMC10275832, DOI: 10.1007/s13311-023-01352-w.Peer-Reviewed Original ResearchConceptsSecondary ischemic stroke preventionIschemic stroke preventionRecurrent ischemic strokeStroke preventionIschemic strokeRisk factorsMajor public health concernSecondary stroke preventionLifestyle risk factorsVascular risk factorsRecurrent stroke riskAvailability of treatmentPublic health concernHealth care systemAHA guidelinesStroke riskSurgical treatmentHealth burdenPatient burdenFirst strokeStrokeHealth concernCare systemPreventionTreatment
2022
Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial
Lang A, de Havenon A, Mac Grory B, Henninger N, Shu L, Furie K, Easton J, Kim A, Johnston S, Yaghi S. Subsequent ischemic stroke and tobacco smoking: A secondary analysis of the POINT trial. European Stroke Journal 2022, 8: 328-333. PMID: 37021190, PMCID: PMC10069178, DOI: 10.1177/23969873221148224.Peer-Reviewed Original ResearchConceptsSubsequent ischemic strokeEffect of clopidogrelSubsequent stroke riskIschemic strokeMajor hemorrhagePoint trialStroke riskSmoking statusMinor Ischemic Stroke (POINT) trialSubgroup interaction analysesMultivariable Cox regressionMinor ischemic strokeIschemic stroke trialsEffect of smokingNon-significant trendNew TIACurrent smokersStroke trialsTobacco smokingCox regressionIndex eventSmokersSecondary analysisClopidogrelStroke
2021
Differentiation of symptomatic and asymptomatic carotid intraplaque hemorrhage using 3D high‐resolution diffusion‐weighted stack of stars imaging
Kim S, Parker D, Roberts J, Treiman G, Alexander M, Baradaran H, de Havenon A, McNally J. Differentiation of symptomatic and asymptomatic carotid intraplaque hemorrhage using 3D high‐resolution diffusion‐weighted stack of stars imaging. NMR In Biomedicine 2021, 34: e4582. PMID: 34296793, DOI: 10.1002/nbm.4582.Peer-Reviewed Original ResearchConceptsApparent diffusion coefficientCarotid diseaseApparent diffusion coefficient valuesDiffusion-weighted (DW) imagingApparent diffusion coefficient measurementsSymptomatic plaquesAsymptomatic plaquesInternal carotid artery plaqueWilcoxon-Mann-Whitney U testIntraplaque hemorrhageCarotid intraplaque hemorrhageCarotid artery plaquesElevated stroke riskAssociated with plaque instabilityImprove detectionSymptomatic statusHealthy subjectsQuantitative diffusion measurementsU testCarotid atherosclerosisArtery plaquesPlaque instabilityPhantom studyStroke riskHemorrhageCarotid Stenosis and Recurrent Ischemic Stroke
Yaghi S, de Havenon A, Rostanski S, Kvernland A, Mac Grory B, Furie KL, Kim AS, Easton JD, Johnston SC, Henninger N. Carotid Stenosis and Recurrent Ischemic Stroke. Stroke 2021, 52: 2414-2417. PMID: 33940954, PMCID: PMC8268075, DOI: 10.1161/strokeaha.121.034089.Peer-Reviewed Original ResearchConceptsHigh-risk transient ischemic attackTransient ischemic attackEffect of clopidogrelMinor ischemic strokeIschemic strokeIschemic stroke riskCarotid stenosisIschemic attackStroke riskCervical internal carotid arteryAddition of clopidogrelDual antiplatelet therapyRecurrent ischemic strokeCox regression modelInternal carotid arteryAntiplatelet therapyPrimary outcomePoint trialCarotid arteryInclusion criteriaClopidogrelAdjusted modelStenosisPatientsStroke
2017
Magnetic Resonance Imaging Detection of Intraplaque Hemorrhage
McNally JS, Kim SE, Mendes J, Hadley JR, Sakata A, De Havenon AH, Treiman GS, Parker DL. Magnetic Resonance Imaging Detection of Intraplaque Hemorrhage. Magnetic Resonance Insights 2017, 10: 1178623x17694150. PMID: 28469441, PMCID: PMC5348123, DOI: 10.1177/1178623x17694150.Peer-Reviewed Original ResearchCarotid intraplaque hemorrhageFuture stroke riskIntraplaque hemorrhageStroke riskCarotid artery atherosclerosisPercent diameter stenosisMagnetic resonance imaging (MRI) detectionT1-weighted MRI sequencesMagnetic resonance imaging sequenceArtery atherosclerosisIschemic strokeStroke etiologyDiameter stenosisClinical trialsHemorrhageClinical useMajor causeStroke sourcesMRI sequencesMRINeck coilImaging sequenceRiskLumenImaging