2024
Higher proceduralist stroke thrombectomy volume is associated with reduced inpatient mortality
Koo A, Renedo D, Ney J, Amllay A, Kanzler M, Stogniy S, Alawieh A, Sujijantarat N, Antonios J, Al Kasab S, Malhotra A, Hebert R, Matouk C, de Havenon A. Higher proceduralist stroke thrombectomy volume is associated with reduced inpatient mortality. Journal Of NeuroInterventional Surgery 2024, jnis-2024-022021. PMID: 39214687, DOI: 10.1136/jnis-2024-022021.Peer-Reviewed Original ResearchIn-hospital deathIn-hospital mortalityAcute ischemic strokeCut-pointsAbsolute risk of deathAssociated with lower oddsState Inpatient DatabasesFlorida State Inpatient DatabaseIn-hospital moralityRates of in-hospital mortalityDiagnosis of acute ischemic strokePrimary study outcomeRisk of deathStroke careOptimal cut-pointAssociated with reduced inpatient mortalityEndovascular thrombectomyRetrospective cohort studyLower oddsPotential confoundersAbsolute riskAcute ischemic stroke patientsInpatient mortalityCohort studyInpatient Database
2023
791-P: Comparing the Real-World Effects of Once-Weekly GLP-1 RAs and DPP-4 Inhibitors on Ischemic Stroke and Myocardial Infarction in Individuals with T2D and ASCVD
TAN X, LIANG Y, RAJPURA J, YEDIGAROVA L, NOONE J, XIE L, DE HAVENON A. 791-P: Comparing the Real-World Effects of Once-Weekly GLP-1 RAs and DPP-4 Inhibitors on Ischemic Stroke and Myocardial Infarction in Individuals with T2D and ASCVD. Diabetes 2023, 72 DOI: 10.2337/db23-791-p.Peer-Reviewed Original ResearchAtherosclerotic cardiovascular diseaseGLP-1 RAsMyocardial infarctionDPP-4iIschemic strokeCardiovascular eventsNovo NordiskGlucagon-like peptide-1 receptor agonistsWeekly glucagon-like peptide-1 receptor agonistMajor adverse cardiovascular eventsPeptide-1 receptor agonistsDipeptidyl peptidase-4 inhibitorsRisk of MINew adult usersAdverse cardiovascular eventsRetrospective cohort studyPeptidase-4 inhibitorsDPP-4 inhibitorsType 2 diabetesReal-world evidenceDrug discontinuationBaseline characteristicsCohort studyOptum ClinformaticsReceptor agonist
2021
Characteristics and Outcomes Among US Patients Hospitalized for Ischemic Stroke Before vs During the COVID-19 Pandemic
de Havenon A, Ney JP, Callaghan B, Hohmann S, Shippey E, Yaghi S, Anadani M, Majersik JJ. Characteristics and Outcomes Among US Patients Hospitalized for Ischemic Stroke Before vs During the COVID-19 Pandemic. JAMA Network Open 2021, 4: e2110314. PMID: 33999162, PMCID: PMC8129817, DOI: 10.1001/jamanetworkopen.2021.10314.Peer-Reviewed Original ResearchConceptsIschemic strokeCOVID-19 groupCohort studyUS patientsCOVID-19Prepandemic levelsLaboratory-confirmed COVID-19Vizient Clinical Data BaseCOVID-19 pandemicRetrospective cohort studyAcute coronary syndromeOutcomes of hospitalizationHospital discharge ratesTime of admissionHospitalization of patientsCOVID-19 statusClinical data baseNonelective basisCoronary syndromeHospital deathHospital dischargePulmonary emboliBaseline factorsHispanic patientsNonfederal hospitals
2020
Anticoagulation use and Hemorrhagic Stroke in SARS-CoV-2 Patients Treated at a New York Healthcare System
Kvernland A, Kumar A, Yaghi S, Raz E, Frontera J, Lewis A, Czeisler B, Kahn DE, Zhou T, Ishida K, Torres J, Riina HA, Shapiro M, Nossek E, Nelson PK, Tanweer O, Gordon D, Jain R, Dehkharghani S, Henninger N, de Havenon A, Grory BM, Lord A, Melmed K. Anticoagulation use and Hemorrhagic Stroke in SARS-CoV-2 Patients Treated at a New York Healthcare System. Neurocritical Care 2020, 34: 748-759. PMID: 32839867, PMCID: PMC7444897, DOI: 10.1007/s12028-020-01077-0.Peer-Reviewed Original ResearchConceptsHemorrhagic strokeTherapeutic anticoagulationClinical characteristicsThrombotic complicationsHistorical controlsCOVID-19Exact testHigher initial NIHSS scoreSARS-CoV-2 patientsInitial NIHSS scoreRetrospective cohort studyHealthcare systemFischer's exact testCOVID-19 infectionNon-aneurysmal SAHMajor healthcare systemOverall low rateAnticoagulation useEmpiric anticoagulationHospital mortalityNIHSS scoreCohort studyCommon etiologyIntraparenchymal hemorrhageMost hemorrhages
2017
Association of Collateral Blood Vessels Detected by Arterial Spin Labeling Magnetic Resonance Imaging With Neurological Outcome After Ischemic Stroke
de Havenon A, Haynor DR, Tirschwell DL, Majersik JJ, Smith G, Cohen W, Andre JB. Association of Collateral Blood Vessels Detected by Arterial Spin Labeling Magnetic Resonance Imaging With Neurological Outcome After Ischemic Stroke. JAMA Neurology 2017, 74: 453-458. PMID: 28192548, PMCID: PMC5470363, DOI: 10.1001/jamaneurol.2016.4491.Peer-Reviewed Original ResearchConceptsAcute ischemic strokeArterial spin labeling magnetic resonance imagingCollateral blood vesselsNeurologic outcomeMRS scoreMagnetic resonance imagingNeurological outcomeIschemic strokeScale scoreHealth Stroke Scale scoreResonance imagingMultivariable ordinal logistic regression modelsTertiary academic medical centerBlood vesselsAdmission National InstitutesPremorbid mRS scoreGood neurologic outcomeGood neurological outcomeRetrospective cohort studyStroke Scale scoreRankin Scale scorePresence of collateralsAcademic medical centerLogistic regression modelsOrdinal logistic regression models
2016
Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA
Eisenmenger LB, Aldred BW, Kim S, Stoddard GJ, de Havenon A, Treiman GS, Parker DL, McNally JS. Prediction of Carotid Intraplaque Hemorrhage Using Adventitial Calcification and Plaque Thickness on CTA. American Journal Of Neuroradiology 2016, 37: 1496-1503. PMID: 27102316, PMCID: PMC7960279, DOI: 10.3174/ajnr.a4765.Peer-Reviewed Original ResearchConceptsMaximum soft plaque thicknessCarotid intraplaque hemorrhageAdventitial calcificationIntraplaque hemorrhageRim signPlaque thicknessRetrospective cohort studyAtherosclerosis risk factorsMaximum plaque thicknessMultivariable Poisson regressionNASCET stenosisCohort studyAdventitial inflammationRisk factorsPlaque instabilityCarotid arteryHemorrhageUlcerationSoft plaqueStenosisIntraluminal thrombusPoisson regressionFinal modelCalcificationCarotid MRA