Featured Publications
Personalised recommendations for hospitalised patients with Acute Kidney Injury using a Kidney Action Team (KAT-AKI): protocol and early data of a randomised controlled trial
Aklilu A, O’Connor K, Martin M, Yamamoto Y, Coronel-Moreno C, Shvets K, Jones C, Kadhim B, Corona-Villalobos C, Baker M, Tan J, Freeman N, Groener M, Menez S, Brown D, Culli S, Lindsley J, Orias M, Parikh C, Smith A, Sundararajan A, Wilson F. Personalised recommendations for hospitalised patients with Acute Kidney Injury using a Kidney Action Team (KAT-AKI): protocol and early data of a randomised controlled trial. BMJ Open 2023, 13: e071968. PMID: 37068906, PMCID: PMC10111926, DOI: 10.1136/bmjopen-2023-071968.Peer-Reviewed Original ResearchConceptsPrimary teamAcute Kidney Injury OutcomesAKI alert systemInvestigator-blinded trialUsual care armKey secondary outcomesClinical decision support toolIntensive care unitUS hospital systemAKI alertsAKI detectionAKI progressionCare armSecondary outcomesPrimary outcomeCare unitMedian timeMedical floorPercentage of recommendationsDiagnostic interventionsInjury outcomesRandomisationHospital systemEthics CommitteeDedicated teamA randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes
Wilson F, Yamamoto Y, Martin M, Coronel-Moreno C, Li F, Cheng C, Aklilu A, Ghazi L, Greenberg J, Latham S, Melchinger H, Mansour S, Moledina D, Parikh C, Partridge C, Testani J, Ugwuowo U. A randomized clinical trial assessing the effect of automated medication-targeted alerts on acute kidney injury outcomes. Nature Communications 2023, 14: 2826. PMID: 37198160, PMCID: PMC10192367, DOI: 10.1038/s41467-023-38532-3.Peer-Reviewed Original ResearchConceptsAcute kidney injuryUsual care groupKidney injuryCare groupAcute Kidney Injury OutcomesAlert groupNon-steroidal anti-inflammatory drugsComposite of progressionHours of randomizationMedications of interestAldosterone system inhibitorsClasses of medicationsProton pump inhibitorsRandomized clinical trialsAnti-inflammatory drugsClinical decision support systemNephrotoxic medicationsHospitalized adultsDiscontinuation ratesCertain medicationsPrimary outcomeSubstantial morbiditySystem inhibitorsPump inhibitorsParallel groupChemotherapy-Associated Thrombotic Microangiopathy
Aklilu A, Shirali A. Chemotherapy-Associated Thrombotic Microangiopathy. Kidney360 2023, 4: 409-422. PMID: 36706238, PMCID: PMC10103319, DOI: 10.34067/kid.0000000000000061.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsDrug-induced thrombotic microangiopathyThrombotic microangiopathyPlasma exchangePrimary atypical hemolytic uremic syndromeAtypical hemolytic uremic syndromeEnd-organ dysfunctionMicroangiopathic hemolytic anemiaSecondary thrombotic microangiopathyTherapeutic plasma exchangeTerminal complement inhibitorLarge multicenter studyHemolytic uremic syndromeRole of complementPotential treatment strategyProteinuria reductionSupportive careBlood pressureMulticenter studyTreatment courseUremic syndromeComplement inhibitionTreatment strategiesHemolytic anemiaAntiangiogenesis agentsComplement inhibitorsDiagnosis of Chronic Kidney Disease and Assessing Glomerular Filtration Rate
Aklilu A. Diagnosis of Chronic Kidney Disease and Assessing Glomerular Filtration Rate. Medical Clinics Of North America 2023, 107: 641-658. PMID: 37258004, DOI: 10.1016/j.mcna.2023.03.001.Peer-Reviewed Original ResearchDiversity in Studies Developing Kidney Function Estimating Equations: Improving Representation, Interpretation, and Utility of Clinical Research
Alvarado F, Aklilu A, Powe N, Vart P, Delgado C. Diversity in Studies Developing Kidney Function Estimating Equations: Improving Representation, Interpretation, and Utility of Clinical Research. American Journal Of Kidney Diseases 2022, 81: 1-6. PMID: 35842013, DOI: 10.1053/j.ajkd.2022.05.014.Peer-Reviewed Original ResearchThe removal of race from kidney function estimation: Key points for primary providers
Aklilu A, Delgado C. The removal of race from kidney function estimation: Key points for primary providers. Journal Of The National Medical Association 2022, 114: s25-s33. PMID: 35595580, DOI: 10.1016/j.jnma.2022.05.008.Peer-Reviewed Original ResearchConceptsKidney functionKidney function estimationChronic kidney diseasePrimary care providersGlomerular filtration rate estimationKidney dysfunctionKidney diseaseRisk factorsCare providersNephrology societiesSocial determinantsPrimary providersEarly detectionInclusion of raceTask ForceMedical algorithmsRecent recognitionWidespread implementationGFRProvidersDysfunctionRaceDiseaseProgressionAssessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19
Nugent J, Aklilu A, Yamamoto Y, Simonov M, Li F, Biswas A, Ghazi L, Greenberg J, Mansour S, Moledina D, Wilson FP. Assessment of Acute Kidney Injury and Longitudinal Kidney Function After Hospital Discharge Among Patients With and Without COVID-19. JAMA Network Open 2021, 4: e211095. PMID: 33688965, PMCID: PMC7948062, DOI: 10.1001/jamanetworkopen.2021.1095.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overBlack or African AmericanCohort StudiesComorbidityCOVID-19CreatinineFemaleFollow-Up StudiesGlomerular Filtration RateHispanic or LatinoHumansHypertensionKidney Function TestsLongitudinal StudiesMaleMiddle AgedPatient DischargeProportional Hazards ModelsRenal Insufficiency, ChronicRetrospective StudiesSARS-CoV-2United StatesConceptsCOVID-19-associated acute kidney injuryAcute kidney injuryHospital acute kidney injurySubgroup of patientsKidney functionKidney injuryCohort studyHospital dischargeAKI recoveryKidney diseaseCOVID-19Peak creatinine levelsRetrospective cohort studyChronic kidney diseaseDays of dischargeHalf of patientsGlomerular filtration rateCoronavirus disease 2019AKI severityBaseline comorbiditiesEGFR decreaseDialysis requirementEGFR slopeKidney recoveryCreatinine levelsOutcomes Associated with Sodium-Glucose Cotransporter-2 Inhibitor Use in Acute Heart Failure Hospitalizations Complicated by AKI
Aklilu A, Kumar S, Yamamoto Y, Moledina D, Sinha F, Testani J, Wilson F. Outcomes Associated with Sodium-Glucose Cotransporter-2 Inhibitor Use in Acute Heart Failure Hospitalizations Complicated by AKI. Kidney360 2023, 4: 1371-1381. PMID: 37644648, PMCID: PMC10615381, DOI: 10.34067/kid.0000000000000250.Peer-Reviewed Original ResearchConceptsAcute kidney injuryHeart failure hospitalizationSodium-glucose cotransporter-2 inhibitor useSodium-glucose cotransporter 2 inhibitorsAcute heart failure hospitalizationCotransporter 2 inhibitorsCox regression analysisRenal recoveryFailure hospitalizationAKI diagnosisKidney injuryInhibitor useLower riskStage 5 chronic kidney diseaseTime-varying Cox regression analysisKidney Disease Improving Global OutcomesInverse probability-weighted analysisMulticenter retrospective cohort studyMultivariable Cox regression analysisStage 5 CKDAcute heart failureRetrospective cohort studyChronic kidney diseaseKidney function recoveryGlomerular filtration rate
2024
Improving Access to Kidney Transplant: Could Kidneys with AKI Help Narrow the Gap?
Aklilu A, Djamali A. Improving Access to Kidney Transplant: Could Kidneys with AKI Help Narrow the Gap? Kidney360 2024, 5: 933-935. PMID: 39052470, PMCID: PMC11296545, DOI: 10.34067/kid.0000000000000476.Peer-Reviewed Original Research
2021
Eosinophilia and Skin Rash in a Patient with Uncontrolled Hypertension and AKI
Aklilu A. Eosinophilia and Skin Rash in a Patient with Uncontrolled Hypertension and AKI. Kidney360 2021, 2: 2038-2039. PMID: 35419544, PMCID: PMC8986042, DOI: 10.34067/kid.0004422021.Peer-Reviewed Original ResearchA unique case of purple urine: A case report and literature review.
Aklilu AM, Avigan ZM, Brewster UC. A unique case of purple urine: A case report and literature review. Clinical Nephrology 2021, 95: 273-277. PMID: 33605870, DOI: 10.5414/cn110272.Peer-Reviewed Original ResearchConceptsPurple urineUrinary tract infectionBroad differential diagnosisUrine discolorationVasodilatory shockTract infectionsCardiopulmonary bypassBenign causesCase reportDifferential diagnosisUnique caseBacterial colonizationUrinePatientsDrugsHydroxocobalaminLiterature reviewVasoplegiaRhabdomyolysisBypassInfectionCliniciansDiagnosis