Pre-Operative Boost Results in Low Rates of Re-Excision and Reduced Time from Initial Diagnosis to Completion of Local-Regional Treatment in Breast Cancer Patients
Chakraborty M, Sherwani Z, Yehia Z, Ohri N, Cui T, Eladoumikdachi F, Kowzun M, Kumar S, Potdevin L, Toppmeyer D, Haffty B. Pre-Operative Boost Results in Low Rates of Re-Excision and Reduced Time from Initial Diagnosis to Completion of Local-Regional Treatment in Breast Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2024, 120: s201-s202. DOI: 10.1016/j.ijrobp.2024.07.2265.Peer-Reviewed Original ResearchBreast-conserving surgeryWhole breast irradiationDuctal carcinoma in situRe-excision ratesProspective phase II clinical trialRate of re-excisionPhase II clinical trialRe-excisionII clinical trialsHypofractionated regimenWound complicationsPre-operativelyDiagnosis to completionTreated with breast-conserving surgeryClinical trialsInitiation of systemic therapyMedian clinical tumor sizeRisk of wound complicationsIncidence of wound complicationsEarly-stage breast cancerLocal-regional treatmentTumor bed boostClinical tumor sizeNode-positive diseaseCompletion of radiationFirst Results of the Primary Outcome of a Phase II Prospective Clinical Trial to Assess the Feasibility of Preoperative Radiation Boost in Breast Cancer Patients
Yehia Z, Sherwani Z, Chakraborty M, Ohri N, Grann A, Eladoumikdachi F, Kowzun M, Kumar S, Potdevin L, Blackwood M, Toppmeyer D, Haffty B. First Results of the Primary Outcome of a Phase II Prospective Clinical Trial to Assess the Feasibility of Preoperative Radiation Boost in Breast Cancer Patients. International Journal Of Radiation Oncology • Biology • Physics 2024 PMID: 39241809, DOI: 10.1016/j.ijrobp.2024.08.043.Peer-Reviewed Original ResearchWhole breast RTBreast-conserving therapyBoost volumePostoperative RTRT boostPrimary outcomeBreast RTRadiation therapyCosmetic outcomeWound complicationsBreast cancerClinically node-negative breast cancerPhase II prospective clinical trialMedian clinical tumor sizePostoperative whole-breast RTProspective phase 2 trialIncidence of grade 3Node-negative breast cancerProspective phase 2 studyRate of postoperative wound complicationsDuctal carcinoma in situClinical tumor sizeCarcinoma in situPhase 2 studyPhase 2 trial