2024
Estimates of 30-day postoperative pulmonary complications after gastrointestinal endoscopic procedures: A retrospective cohort analysis of a health system population
Carr Z, Li J, Agarkov D, Gazura M, Karamchandani K. Estimates of 30-day postoperative pulmonary complications after gastrointestinal endoscopic procedures: A retrospective cohort analysis of a health system population. PLOS ONE 2024, 19: e0299137. PMID: 38394250, PMCID: PMC10889900, DOI: 10.1371/journal.pone.0299137.Peer-Reviewed Original ResearchConceptsPostoperative pulmonary complicationsGastrointestinal endoscopic proceduresCongestive heart failurePropensity score matchingEndoscopic proceduresPulmonary complicationsSecondary outcomesPropensity score matching adjustmentRetrospective cohort studyRetrospective cohort analysisPulmonary circulatory disordersMultivariate logistic regressionAlcohol abuse disordersUpper endoscopic proceduresHealth system populationPulmonary emboliUpper endoscopyRespiratory failureLower endoscopyElectrolyte disordersHeart failureCohort studyConscious sedationPrimary outcomeCohort analysis
2023
Predictors of Failure to Rescue After Postoperative Respiratory Failure: A Retrospective Cohort Analysis of 13,047 Patients Using the ACS-NSQIP Dataset
Karamchandani K, Khorsand S, Ebeling C, Yan L, Nakonezny P, Carr Z. Predictors of Failure to Rescue After Postoperative Respiratory Failure: A Retrospective Cohort Analysis of 13,047 Patients Using the ACS-NSQIP Dataset. Journal Of Surgical Research 2023, 293: 482-489. PMID: 37827025, DOI: 10.1016/j.jss.2023.09.030.Peer-Reviewed Original ResearchConceptsPostoperative respiratory failurePredictors of failureDay of surgeryRespiratory failureNoncardiac surgeryNational Surgical Quality Improvement Project databaseSurgeons National Surgical Quality Improvement Project databaseMultiple logistic regression modelACS-NSQIP datasetsPreoperative prealbumin levelRetrospective cohort studyAnesthesiologists physical statusRetrospective cohort analysisLogistic regression modelsPreoperative ascitesPreoperative creatininePostoperative complicationsPrealbumin levelsCohort studyStudy cohortDisseminated cancerCohort analysisAmerican CollegePatientsPhysical statusPerioperative Pulmonary Complications in the Elderly The Forgotten System
Carr Z, Siller S, McDowell B. Perioperative Pulmonary Complications in the Elderly The Forgotten System. Anesthesiology Clinics 2023, 41: 531-548. PMID: 37516493, DOI: 10.1016/j.anclin.2023.02.005.Peer-Reviewed Original Research
2022
A 10-mg dose of amiloride increases time to failure during blood-flow-restricted plantar flexion in healthy adults without influencing blood pressure
Stavres J, Luck J, Hamaoka T, Blaha C, Cauffman A, Dalton P, Herr MD, Ruiz-Velasco V, Carr Z, Janicki P, Cui J. A 10-mg dose of amiloride increases time to failure during blood-flow-restricted plantar flexion in healthy adults without influencing blood pressure. AJP Regulatory Integrative And Comparative Physiology 2022, 323: r875-r888. PMID: 36222880, PMCID: PMC9678418, DOI: 10.1152/ajpregu.00190.2022.Peer-Reviewed Original ResearchConceptsBlood pressure indexTime-tension indexMean blood pressureBlood pressureAcid-sensing ion channelsDose of amilorideHealthy adultsOral doseIsometric plantar flexion exercisesVolume-matched placeboTotal exercise durationBlood pressure responseSingle oral doseHeart rate responsePlantar flexion exerciseBFR exerciseExercise tolerancePlacebo trialMuscle painExercise durationFlexion exercisePlantar flexionHeart ratePressure indexPain
2021
Persistent Postoperative Vasoplegia After Ureteronephrectomy Due To Suspected Intravesical Gemcitabine Toxicity
Yan L, Bohorquez MA, Carr ZJ. Persistent Postoperative Vasoplegia After Ureteronephrectomy Due To Suspected Intravesical Gemcitabine Toxicity. A&A Practice 2021, 15: e01537. PMID: 34695040, DOI: 10.1213/xaa.0000000000001537.Peer-Reviewed Case Reports and Technical NotesConceptsIntravesical adjuvant therapyPulmonary embolic phenomenaTreatment of patientsPotential adverse eventsPostoperative vasoplegiaRobotic nephroureterectomyVasopressor supportAdjuvant therapyPostoperative courseAdverse eventsEmbolic phenomenaSupportive managementResuscitative effortsAllergic reactionsCommon causeVasoplegiaGemcitabine toxicityGemcitabinePatientsUreteronephrectomyNephroureterectomyBleedingTherapyInfectionEndocrine emergencies in anesthesia
Fernandez-Robles C, Carr ZJ, Oprea AD. Endocrine emergencies in anesthesia. Current Opinion In Anaesthesiology 2021, 34: 326-334. PMID: 33935181, DOI: 10.1097/aco.0000000000000986.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEndocrine disordersPerioperative managementOral hyperglycemic agentsPerioperative fluid resuscitationPerioperative glycemic managementSafe perioperative managementCommon endocrine disorderPerioperative time periodNumber of patientsBetter operative outcomesInvasive surgical techniquesCarcinoid syndromeEndocrine emergencyAdverse eventsFluid resuscitationGlycemic managementOperative outcomesAvoidable complicationsMedical managementComplex patientsSurgical techniqueHyperglycemic agentOptimal managementOperating roomDisorders
2020
Perioperative risk factors in patients with idiopathic pulmonary fibrosis: a historical cohort study
McDowell BJ, Karamchandani K, Lehman EB, Conboy MJ, Carr ZJ. Perioperative risk factors in patients with idiopathic pulmonary fibrosis: a historical cohort study. Journal Canadien D'anesthésie 2020, 68: 81-91. PMID: 33029686, DOI: 10.1007/s12630-020-01828-9.Peer-Reviewed Original ResearchConceptsAcute respiratory worseningIdiopathic pulmonary fibrosisOne-year mortalityHistorical cohort studyRisk factorsIPF patientsCohort studyPulmonary fibrosisSurgical timeSingle-center historical cohort studyHome oxygen requirementHome oxygen usePostoperative acute exacerbationAdverse postoperative outcomesPerioperative risk factorsIndependent risk factorDay of surgeryPerioperative risk stratificationMultivariable regression analysisActive pneumoniaAcute exacerbationAE-IPFPostoperative pneumoniaRespiratory worseningPerioperative factors
2019
CHA2DS2-VASc Score and In-Hospital Mortality in Critically Ill Patients With New-Onset Atrial Fibrillation
Karamchandani K, Schoaps RS, Abendroth T, Carr ZJ, King TS, Bonavia A. CHA2DS2-VASc Score and In-Hospital Mortality in Critically Ill Patients With New-Onset Atrial Fibrillation. Journal Of Cardiothoracic And Vascular Anesthesia 2019, 34: 1165-1171. PMID: 31899140, DOI: 10.1053/j.jvca.2019.11.044.Peer-Reviewed Original ResearchConceptsNew-onset atrial fibrillationIntensive care unitTertiary care academic institutionHospital mortalityVASc scoreAtrial fibrillationIll patientsAdult patientsVascular diseasePrognostic markerTertiary care academic medical centerAssociation of CHAConcomitant vascular diseaseHospital mortality rateIn-Hospital MortalitySingle-center studyReliable prognostic markersAcademic medical centerElectronic medical recordsCHA2DS2-VAScHospital deathCare unitMedical recordsRetrospective analysisMedical CenterPost‐operative intensive care unit admission after elective non‐cardiac surgery: A single‐center analysis of the NSQIP database
Bruceta M, De Souza L, Carr ZJ, Bonavia A, Kunselman AR, Karamchandani K. Post‐operative intensive care unit admission after elective non‐cardiac surgery: A single‐center analysis of the NSQIP database. Acta Anaesthesiologica Scandinavica 2019, 64: 319-328. PMID: 31710692, DOI: 10.1111/aas.13504.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAgedBody Mass IndexCohort StudiesCritical CareDatabases, FactualElective Surgical ProceduresFemaleHospital MortalityHumansIntensive Care UnitsLength of StayMaleMiddle AgedOperative TimePatient AdmissionPennsylvaniaPostoperative ComplicationsReoperationRisk FactorsSurgical Procedures, OperativeTertiary Care CentersConceptsElective non-cardiac surgeryPost-operative ICU admissionNon-cardiac surgeryIntensive care unitBody mass indexElevated body mass indexCurrent Procedural TerminologyICU admissionACS-NSQIPDisseminated cancerPost-operative intensive care unit admissionIntensive care unit admissionTertiary care academic medical centerLonger hospital lengthSurgery-specific characteristicsCare unit admissionObservational cohort studySingle-center analysisMultivariable logistic regressionICD-9 codesLonger procedure durationAcademic medical centerDisease billing codeHospital mortalityUnit admissionCardiovascular Collapse in a Patient With Parotid Abscess: Dangerous Cross Talk Between the Brain and Heart: A Case Report.
Owusu K, Stredny ES, Williamson G, Carr ZJ, Karamchandani K. Cardiovascular Collapse in a Patient With Parotid Abscess: Dangerous Cross Talk Between the Brain and Heart: A Case Report. A&A Practice 2019, 13: 281-283. PMID: 31385818, DOI: 10.1213/xaa.0000000000001056.Peer-Reviewed Case Reports and Technical NotesConceptsParotid abscessCardiovascular collapseTrigeminal neuralgiaTrigeminocardiac reflexPostsurgical neuropathic painSignificant hemodynamic perturbationsLife-threatening complicationsNeuropathic painSymptomatic bradycardiaCase reportHemodynamic perturbationsOtolaryngologic surgeryEarly diagnosisTimely treatmentAbscessComplicationsPatientsCross talkNeuralgiaBradycardiaPainSurgeryReflexCliniciansDiagnosisStroke prophylaxis in critically-ill patients with new-onset atrial fibrillation
Schoaps RS, Quintili A, Bonavia A, Carr ZJ, Lehman EB, Abendroth T, Karamchandani K. Stroke prophylaxis in critically-ill patients with new-onset atrial fibrillation. Journal Of Thrombosis And Thrombolysis 2019, 48: 394-399. PMID: 30963394, DOI: 10.1007/s11239-019-01854-5.Peer-Reviewed Original ResearchConceptsNew-onset atrial fibrillationCHA2DS2-VASc scoreOral anticoagulant therapyOral anticoagulantsIll patientsStroke prophylaxisAnticoagulant therapyHospital dischargeAtrial fibrillationEffective stroke prophylaxisOnset atrial fibrillationStroke/TIACongestive heart failureLong-term incidenceElectronic medical recordsEligible patientsICU survivorsAdult patientsHeart failureThromboembolic diseaseMedical recordsHigh incidencePatientsAnticoagulantsStudy periodPain management in trauma patients affected by the opioid epidemic: A narrative review.
Karamchandani K, Klick JC, Linskey Dougherty M, Bonavia A, Allen SR, Carr ZJ. Pain management in trauma patients affected by the opioid epidemic: A narrative review. Journal Of Trauma And Acute Care Surgery 2019, 87: 430-439. PMID: 30939572, DOI: 10.1097/ta.0000000000002292.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsOpioid useTrauma patientsNarrative reviewPain managementChronic painOpioid epidemicTraumatic injuryLong-term opioid useAcute opioid withdrawalPersistent opioid useChronic opioid useOpioid use disorderAnalgesic regimensOpioid withdrawalAcute painHospital admissionOpioid dependencePatient populationUse disordersPatientsInadequate treatmentPainAverage riskMultimodal approachInjury
2018
A double blind randomized placebo controlled pilot study of single-dose preoperative modafinil for functional recovery after general anesthesia in patients with obstructive sleep apnea
Carr ZJ, Vells B, Wood BR, Lowery JD, Rogers AM, Kunselman AA, Karamchandani K, Vaida SJ. A double blind randomized placebo controlled pilot study of single-dose preoperative modafinil for functional recovery after general anesthesia in patients with obstructive sleep apnea. Medicine 2018, 97: e12585. PMID: 30278569, PMCID: PMC6181597, DOI: 10.1097/md.0000000000012585.Peer-Reviewed Original ResearchMeSH KeywordsAgedAirway ExtubationAnesthesia Recovery PeriodAnesthesia, GeneralBenzhydryl CompoundsBlood PressureDouble-Blind MethodFemaleHumansLength of StayMaleMiddle AgedModafinilPilot ProjectsPreoperative PeriodProof of Concept StudyRespiratory RateSleep Apnea, ObstructiveWakefulness-Promoting AgentsConceptsObstructive sleep apneaGeneral anesthesiaFunctional recoverySleep apneaPrimary outcomePACU lengthPsychomotor stimulantsPost-anesthesia care unit lengthDiagnosis of OSAIntraoperative bispectral index valuePlacebo-controlled pilot studyPost-anesthesia care unitPilot studyPostoperative pain scoresPost-anesthesia recoveryBispectral index valuesModafinil groupPain scoresSurgical populationNarcotic consumptionArterial pressureDaytime somnolenceCare unitAnesthesiaVolatile anestheticsGender differences in the use of atypical antipsychotic medications for ICU delirium
Karamchandani K, Schoaps RS, Printz J, Kowaleski JM, Carr ZJ. Gender differences in the use of atypical antipsychotic medications for ICU delirium. Critical Care 2018, 22: 220. PMID: 30236134, PMCID: PMC6148964, DOI: 10.1186/s13054-018-2143-5.Peer-Reviewed Original ResearchDoes Dexmedetomidine Ameliorate Postoperative Cognitive Dysfunction? A Brief Review of the Recent Literature
Carr ZJ, Cios TJ, Potter KF, Swick JT. Does Dexmedetomidine Ameliorate Postoperative Cognitive Dysfunction? A Brief Review of the Recent Literature. Current Neurology And Neuroscience Reports 2018, 18: 64. PMID: 30083844, DOI: 10.1007/s11910-018-0873-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUse of dexmedetomidinePostoperative deliriumCognitive dysfunctionAcute postoperative deliriumPostoperative cognitive dysfunctionAlpha-2 agonistsIncidence of POCDAnti-inflammatory propertiesHigh patient mortalityHospital lengthElderly patientsHeart failurePostsurgical patientsPatient mortalityImmunomodulatory effectsVascular diseaseBrain injuryFavorable outcomeClinical studiesDexmedetomidineHigh prevalenceHuman trialsClinical investigationRecent FindingsThereAnimal modelsCritical Care Pain Management in Patients Affected by the Opioid Epidemic: A Review
Karamchandani K, Carr ZJ, Bonavia A, Tung A. Critical Care Pain Management in Patients Affected by the Opioid Epidemic: A Review. Annals Of The American Thoracic Society 2018, 15: 1016-1023. PMID: 29812953, DOI: 10.1513/annalsats.201801-028fr.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsIntensive care unitOpioid dependenceOpioid epidemicLong-term opioid dependenceOpioid-related complicationsOpioid-tolerant patientsCritical care physiciansCritical care communitySufficient analgesiaICU carePain managementCare physiciansCare unitICU physiciansOpioid overdosesClinicians' attentionPatientsDirect careCare communityPhysiciansCareEpidemicDeleterious impactAnalgesiaOpioidsOrgan Dysfunction After Surgery in Patients Treated With Individualized or Standard Blood Pressure Management
Karamchandani K, Carr ZJ, Bonavia A. Organ Dysfunction After Surgery in Patients Treated With Individualized or Standard Blood Pressure Management. JAMA 2018, 319: 719-719. PMID: 29466585, DOI: 10.1001/jama.2017.20935.Commentaries, Editorials and LettersIncreased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis
Carr ZJ, Van De Louw A, Fehr G, Li JD, Kunselman A, Ruiz-Velasco V. Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis. BMC Research Notes 2018, 11: 41. PMID: 29338778, PMCID: PMC5771199, DOI: 10.1186/s13104-018-3165-4.Peer-Reviewed Original ResearchConceptsRNA expressionIntensive care unit admissionBlood white cell countCare unit admissionOdds of mortalityDiagnosis of sepsisBody mass indexIntensive care unitWhite cell countGPR43 expressionUnit admissionOne-unit increaseCare unitMass indexSignificant morbidityQuantitative real-time PCRGPR43 receptorInflammatory responseImmunomodulatory pathwaysReceptor 43Receptor expressionReal-time PCRSepsisCell countPatients
2012
Does Every Code Need a “Reader?” Improvement of Rare Event Management With a Cognitive Aid “Reader” During a Simulated Emergency
Burden AR, Carr ZJ, Staman GW, Littman JJ, Torjman MC. Does Every Code Need a “Reader?” Improvement of Rare Event Management With a Cognitive Aid “Reader” During a Simulated Emergency. Simulation In Healthcare The Journal Of The Society For Simulation In Healthcare 2012, 7: 1-9. PMID: 22113440, DOI: 10.1097/sih.0b013e31822c0f20.Peer-Reviewed Original ResearchMeSH KeywordsAdultCritical CareEmergency Service, HospitalEvidence-Based MedicineFemaleHeart ArrestHospital Rapid Response TeamHumansInternship and ResidencyMaleMalignant HyperthermiaMedical ErrorsObstetricsPatient SimulationPilot ProjectsPregnancyPregnancy ComplicationsQuality of Health CareReadingVideo RecordingConceptsMalignant hyperthermiaPercent of subjectsCritical care nursesDantrolene dosePrompt treatmentPatient survivalCardiac arrestCare nursesObstetric traineesTreatment decisionsPhysiologic variablesCritical treatment stepsResuscitation cartResident physiciansCognitive aidsSubjectsAnesthesiologyCA useMedical studentsCritical actionsPercentPrior lectureAnesthesiologistsSimulated emergencyNurses
2010
Ball valve effect precipitating an anesthesia circuit obstruction by an intravenous set cap within the elbow connector
Carr ZJ, Deal ER, Goldberg ME. Ball valve effect precipitating an anesthesia circuit obstruction by an intravenous set cap within the elbow connector. Journal Of Clinical Anesthesia 2010, 22: 486-487. PMID: 20868975, DOI: 10.1016/j.jclinane.2009.12.009.Peer-Reviewed Case Reports and Technical Notes