2023
Perioperative Pulmonary Complications in the Elderly The Forgotten System
Carr Z, Siller S, McDowell B. Perioperative Pulmonary Complications in the Elderly The Forgotten System. Anesthesiology Clinics 2023, 41: 531-548. PMID: 37516493, DOI: 10.1016/j.anclin.2023.02.005.Peer-Reviewed Original Research
2019
CHA2DS2-VASc Score and In-Hospital Mortality in Critically Ill Patients With New-Onset Atrial Fibrillation
Karamchandani K, Schoaps RS, Abendroth T, Carr ZJ, King TS, Bonavia A. CHA2DS2-VASc Score and In-Hospital Mortality in Critically Ill Patients With New-Onset Atrial Fibrillation. Journal Of Cardiothoracic And Vascular Anesthesia 2019, 34: 1165-1171. PMID: 31899140, DOI: 10.1053/j.jvca.2019.11.044.Peer-Reviewed Original ResearchConceptsNew-onset atrial fibrillationIntensive care unitTertiary care academic institutionHospital mortalityVASc scoreAtrial fibrillationIll patientsAdult patientsVascular diseasePrognostic markerTertiary care academic medical centerAssociation of CHAConcomitant vascular diseaseHospital mortality rateIn-Hospital MortalitySingle-center studyReliable prognostic markersAcademic medical centerElectronic medical recordsCHA2DS2-VAScHospital deathCare unitMedical recordsRetrospective analysisMedical CenterPost‐operative intensive care unit admission after elective non‐cardiac surgery: A single‐center analysis of the NSQIP database
Bruceta M, De Souza L, Carr ZJ, Bonavia A, Kunselman AR, Karamchandani K. Post‐operative intensive care unit admission after elective non‐cardiac surgery: A single‐center analysis of the NSQIP database. Acta Anaesthesiologica Scandinavica 2019, 64: 319-328. PMID: 31710692, DOI: 10.1111/aas.13504.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAdultAgedBody Mass IndexCohort StudiesCritical CareDatabases, FactualElective Surgical ProceduresFemaleHospital MortalityHumansIntensive Care UnitsLength of StayMaleMiddle AgedOperative TimePatient AdmissionPennsylvaniaPostoperative ComplicationsReoperationRisk FactorsSurgical Procedures, OperativeTertiary Care CentersConceptsElective non-cardiac surgeryPost-operative ICU admissionNon-cardiac surgeryIntensive care unitBody mass indexElevated body mass indexCurrent Procedural TerminologyICU admissionACS-NSQIPDisseminated cancerPost-operative intensive care unit admissionIntensive care unit admissionTertiary care academic medical centerLonger hospital lengthSurgery-specific characteristicsCare unit admissionObservational cohort studySingle-center analysisMultivariable logistic regressionICD-9 codesLonger procedure durationAcademic medical centerDisease billing codeHospital mortalityUnit admissionStroke prophylaxis in critically-ill patients with new-onset atrial fibrillation
Schoaps RS, Quintili A, Bonavia A, Carr ZJ, Lehman EB, Abendroth T, Karamchandani K. Stroke prophylaxis in critically-ill patients with new-onset atrial fibrillation. Journal Of Thrombosis And Thrombolysis 2019, 48: 394-399. PMID: 30963394, DOI: 10.1007/s11239-019-01854-5.Peer-Reviewed Original ResearchConceptsNew-onset atrial fibrillationCHA2DS2-VASc scoreOral anticoagulant therapyOral anticoagulantsIll patientsStroke prophylaxisAnticoagulant therapyHospital dischargeAtrial fibrillationEffective stroke prophylaxisOnset atrial fibrillationStroke/TIACongestive heart failureLong-term incidenceElectronic medical recordsEligible patientsICU survivorsAdult patientsHeart failureThromboembolic diseaseMedical recordsHigh incidencePatientsAnticoagulantsStudy period
2018
A double blind randomized placebo controlled pilot study of single-dose preoperative modafinil for functional recovery after general anesthesia in patients with obstructive sleep apnea
Carr ZJ, Vells B, Wood BR, Lowery JD, Rogers AM, Kunselman AA, Karamchandani K, Vaida SJ. A double blind randomized placebo controlled pilot study of single-dose preoperative modafinil for functional recovery after general anesthesia in patients with obstructive sleep apnea. Medicine 2018, 97: e12585. PMID: 30278569, PMCID: PMC6181597, DOI: 10.1097/md.0000000000012585.Peer-Reviewed Original ResearchMeSH KeywordsAgedAirway ExtubationAnesthesia Recovery PeriodAnesthesia, GeneralBenzhydryl CompoundsBlood PressureDouble-Blind MethodFemaleHumansLength of StayMaleMiddle AgedModafinilPilot ProjectsPreoperative PeriodProof of Concept StudyRespiratory RateSleep Apnea, ObstructiveWakefulness-Promoting AgentsConceptsObstructive sleep apneaGeneral anesthesiaFunctional recoverySleep apneaPrimary outcomePACU lengthPsychomotor stimulantsPost-anesthesia care unit lengthDiagnosis of OSAIntraoperative bispectral index valuePlacebo-controlled pilot studyPost-anesthesia care unitPilot studyPostoperative pain scoresPost-anesthesia recoveryBispectral index valuesModafinil groupPain scoresSurgical populationNarcotic consumptionArterial pressureDaytime somnolenceCare unitAnesthesiaVolatile anestheticsDoes Dexmedetomidine Ameliorate Postoperative Cognitive Dysfunction? A Brief Review of the Recent Literature
Carr ZJ, Cios TJ, Potter KF, Swick JT. Does Dexmedetomidine Ameliorate Postoperative Cognitive Dysfunction? A Brief Review of the Recent Literature. Current Neurology And Neuroscience Reports 2018, 18: 64. PMID: 30083844, DOI: 10.1007/s11910-018-0873-z.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsUse of dexmedetomidinePostoperative deliriumCognitive dysfunctionAcute postoperative deliriumPostoperative cognitive dysfunctionAlpha-2 agonistsIncidence of POCDAnti-inflammatory propertiesHigh patient mortalityHospital lengthElderly patientsHeart failurePostsurgical patientsPatient mortalityImmunomodulatory effectsVascular diseaseBrain injuryFavorable outcomeClinical studiesDexmedetomidineHigh prevalenceHuman trialsClinical investigationRecent FindingsThereAnimal modelsIncreased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis
Carr ZJ, Van De Louw A, Fehr G, Li JD, Kunselman A, Ruiz-Velasco V. Increased whole blood FFA2/GPR43 receptor expression is associated with increased 30-day survival in patients with sepsis. BMC Research Notes 2018, 11: 41. PMID: 29338778, PMCID: PMC5771199, DOI: 10.1186/s13104-018-3165-4.Peer-Reviewed Original ResearchConceptsRNA expressionIntensive care unit admissionBlood white cell countCare unit admissionOdds of mortalityDiagnosis of sepsisBody mass indexIntensive care unitWhite cell countGPR43 expressionUnit admissionOne-unit increaseCare unitMass indexSignificant morbidityQuantitative real-time PCRGPR43 receptorInflammatory responseImmunomodulatory pathwaysReceptor 43Receptor expressionReal-time PCRSepsisCell countPatients