2019
Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity
Stutz B, Nasrallah C, Nigro M, Curry D, Liu ZW, Gao XB, Elsworth JD, Mintz L, Horvath TL. Dopamine neuronal protection in the mouse Substantia nigra by GHSR is independent of electric activity. Molecular Metabolism 2019, 24: 120-138. PMID: 30833218, PMCID: PMC6531791, DOI: 10.1016/j.molmet.2019.02.005.Peer-Reviewed Original ResearchConceptsSN DA neuronsDA neuronsSubstantia nigraDA cellsDopamine outputNeuronal protectionNeuronal survivalParkinson's diseaseDA neuron survivalDA neuronal survivalDesigner drugs (DREADD) technologyNeuronal pacemaker activityElectrical activityMouse substantia nigraElectric activityNeuron electrical activityAnimal motor behaviorGhrelin activationGHSR activationTetrahydropyridine (MPTP) treatmentNeuroprotective factorsNeuron survivalDopamine neuronsGhrelin receptorExogenous administration
2017
Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons
Suyama S, Ralevski A, Liu ZW, Dietrich MO, Yada T, Simonds SE, Cowley MA, Gao XB, Diano S, Horvath TL. Plasticity of calcium-permeable AMPA glutamate receptors in Pro-opiomelanocortin neurons. ELife 2017, 6: e25755. PMID: 28762946, PMCID: PMC5538821, DOI: 10.7554/elife.25755.Peer-Reviewed Original ResearchConceptsExcitatory postsynaptic currentsPOMC neuronsCP-AMPARsFasted stateAMPAR-mediated excitatory postsynaptic currentsCalcium-permeable AMPA glutamate receptorsInhibition of EPSCsHigh-fat diet exposurePOMC neuronal activityPro-opiomelanocortin (POMC) neuronsCalcium-permeable AMPARsElevated leptin levelsAMPA glutamate receptorsAmplitude of mEPSCsFood deprivationEntry of calciumAMPA receptor complexesDiet exposureLeptin levelsPostsynaptic currentsEPSC amplitudeGlutamate receptorsNeuronal activityExtracellular calciumLinear current-voltage relationship
2006
Adenosine Inhibits Activity of Hypocretin/Orexin Neurons by the A1 Receptor in the Lateral Hypothalamus: A Possible Sleep-Promoting Effect
Liu ZW, Gao XB. Adenosine Inhibits Activity of Hypocretin/Orexin Neurons by the A1 Receptor in the Lateral Hypothalamus: A Possible Sleep-Promoting Effect. Journal Of Neurophysiology 2006, 97: 837-848. PMID: 17093123, PMCID: PMC1783688, DOI: 10.1152/jn.00873.2006.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAdenosineAdenosine A1 Receptor AgonistsAnimalsArousalCalcium ChannelsDose-Response Relationship, DrugExcitatory Postsynaptic PotentialsGreen Fluorescent ProteinsHypothalamic Area, LateralImmunohistochemistryIntracellular Signaling Peptides and ProteinsMiceMice, TransgenicNeural InhibitionNeuronsNeuropeptidesOrexinsOrgan Culture TechniquesPertussis ToxinReceptor, Adenosine A1SleepSynaptic TransmissionConceptsHypocretin/orexin neuronsOrexin neuronsSleep-promoting effectsLateral hypothalamusBasal forebrainA1 receptorsMiniature excitatory postsynaptic currentsVoltage-dependent calcium currentsAdenosine-mediated inhibitionHypocretin/orexin systemExcitatory postsynaptic potentialsExcitatory synaptic transmissionExcitatory postsynaptic currentsEffects of adenosineHypocretin/orexinPostsynaptic currentsOrexin systemPostsynaptic potentialsCalcium currentSynaptic transmissionBrain slicesPertussis toxinSleep promoterAdenosine receptorsAction potentialsGhrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite
Abizaid A, Liu ZW, Andrews ZB, Shanabrough M, Borok E, Elsworth JD, Roth RH, Sleeman MW, Picciotto MR, Tschöp MH, Gao XB, Horvath TL. Ghrelin modulates the activity and synaptic input organization of midbrain dopamine neurons while promoting appetite. Journal Of Clinical Investigation 2006, 116: 3229-3239. PMID: 17060947, PMCID: PMC1618869, DOI: 10.1172/jci29867.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsAppetiteDopamineFluorescent Antibody TechniqueGhrelinMaleMesencephalonMiceMice, Inbred C57BLMice, KnockoutNeuronsNucleus AccumbensPatch-Clamp TechniquesPeptide HormonesRatsRats, Sprague-DawleyReceptors, GhrelinReceptors, G-Protein-CoupledTime FactorsVentral Tegmental AreaConceptsVentral tegmental areaGHSR-deficient miceGHSR-dependent mannerGut hormone ghrelinDopamine neuronal activityMidbrain dopamine neuronsMesolimbic reward circuitrySynaptic input organizationPeripheral ghrelinRebound feedingVTA administrationOrexigenic effectDopamine turnoverGHSR antagonistDopamine neuronsHypothalamic centersTegmental areaHormone ghrelinNucleus accumbensGhrelinNeuronal activitySynapse formationReward circuitryInput organizationFeeding scheduleLeptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M, DiLeone RJ. Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding. Neuron 2006, 51: 801-810. PMID: 16982424, DOI: 10.1016/j.neuron.2006.08.023.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsDopamineEatingFeeding BehaviorGene ExpressionIn Situ Hybridization, FluorescenceIn Vitro TechniquesInfusions, IntravenousLeptinMesencephalonMiceMice, Inbred C57BLMotor ActivityNeuronsPhosphorylationRatsRats, Sprague-DawleyReceptors, Cell SurfaceReceptors, LeptinRNA InterferenceRNA, MessengerSignal TransductionSTAT3 Transcription FactorVentral Tegmental AreaConceptsVentral tegmental areaVTA dopamine neuronsDopamine neuronsFood intakePeripheral metabolic signalsNormal food intakeMidbrain dopamine neuronsLeptin receptor signalingLeptin hormoneTegmental areaLEPR expressionLeptin receptor functionLocomotor activityPalatable foodDirect administrationReceptor functionFiring rateReceptor signalingDirect actionNeuronsLEPR mRNAFunctional evidenceLeptinRNAi-mediated knockdownMetabolic signals