2018
Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice†
Li T, Mamillapalli R, Ding S, Chang H, Liu ZW, Gao XB, Taylor HS. Endometriosis alters brain electrophysiology, gene expression and increases pain sensitization, anxiety, and depression in female mice†. Biology Of Reproduction 2018, 99: 349-359. PMID: 29425272, PMCID: PMC6692844, DOI: 10.1093/biolre/ioy035.Peer-Reviewed Original ResearchConceptsEffect of endometriosisPain sensitizationPain perceptionBrain electrophysiologyEstrogen-dependent inflammatory disorderReproductive-aged womenDetection of endometriosisRegions of brainPatch-clamp recordingsCentral sensitizationPelvic painGene expressionInflammatory disordersEndometriosis miceFemale miceSham controlsMood disordersEndometriosisPainClamp recordingsBehavioral testsMiceBrain gene expressionSensitizationElectrophysiology
2006
Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding
Hommel JD, Trinko R, Sears RM, Georgescu D, Liu ZW, Gao XB, Thurmon JJ, Marinelli M, DiLeone RJ. Leptin Receptor Signaling in Midbrain Dopamine Neurons Regulates Feeding. Neuron 2006, 51: 801-810. PMID: 16982424, DOI: 10.1016/j.neuron.2006.08.023.Peer-Reviewed Original ResearchMeSH KeywordsAction PotentialsAnimalsDopamineEatingFeeding BehaviorGene ExpressionIn Situ Hybridization, FluorescenceIn Vitro TechniquesInfusions, IntravenousLeptinMesencephalonMiceMice, Inbred C57BLMotor ActivityNeuronsPhosphorylationRatsRats, Sprague-DawleyReceptors, Cell SurfaceReceptors, LeptinRNA InterferenceRNA, MessengerSignal TransductionSTAT3 Transcription FactorVentral Tegmental AreaConceptsVentral tegmental areaVTA dopamine neuronsDopamine neuronsFood intakePeripheral metabolic signalsNormal food intakeMidbrain dopamine neuronsLeptin receptor signalingLeptin hormoneTegmental areaLEPR expressionLeptin receptor functionLocomotor activityPalatable foodDirect administrationReceptor functionFiring rateReceptor signalingDirect actionNeuronsLEPR mRNAFunctional evidenceLeptinRNAi-mediated knockdownMetabolic signals