2012
Prolyl Endopeptidase-Deficient Mice Have Reduced Synaptic Spine Density in the CA1 Region of the Hippocampus, Impaired LTP, and Spatial Learning and Memory
D'Agostino G, Kim JD, Liu ZW, Jeong JK, Suyama S, Calignano A, Gao XB, Schwartz M, Diano S. Prolyl Endopeptidase-Deficient Mice Have Reduced Synaptic Spine Density in the CA1 Region of the Hippocampus, Impaired LTP, and Spatial Learning and Memory. Cerebral Cortex 2012, 23: 2007-2014. PMID: 22767632, PMCID: PMC3841400, DOI: 10.1093/cercor/bhs199.Peer-Reviewed Original ResearchConceptsSynaptic spine densitySpine densityCA1 regionProlyl endopeptidaseHippocampal long-term potentiationLong-term potentiationHippocampal-mediated learningImpaired LTPWild-type controlsSpatial memory formationHippocampal plasticityCognitive impairmentPharmacological manipulationNeurodegenerative disordersSpatial learningMemory formationHippocampusPossible roleMicePhysiological functionsSerine proteasesBehavioral approachPotentiationDiseaseNeuropeptides
2009
Prolylcarboxypeptidase regulates food intake by inactivating α-MSH in rodents
Wallingford N, Perroud B, Gao Q, Coppola A, Gyengesi E, Liu ZW, Gao XB, Diament A, Haus KA, Shariat-Madar Z, Mahdi F, Wardlaw SL, Schmaier AH, Warden CH, Diano S. Prolylcarboxypeptidase regulates food intake by inactivating α-MSH in rodents. Journal Of Clinical Investigation 2009, 119: 2291-2303. PMID: 19620781, PMCID: PMC2719925, DOI: 10.1172/jci37209.Peer-Reviewed Original ResearchConceptsFood intakeHigh-fat diet-induced obesityReduced body fatRegular chow dietDiet-induced obesityPRCP activityWild-type controlsChow dietMelanocortin signalingObese miceWeight maintenanceReal-time PCRAxon terminalsBody fatNeuronal populationsΑ-MSHBrain tissueMRNA expressionMouse strainsSmall molecule protease inhibitorsElevated levelsVivo activityProlylcarboxypeptidaseProtease inhibitorsHypothalamus