2013
Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging
Beerman I, Bock C, Garrison BS, Smith ZD, Gu H, Meissner A, Rossi DJ. Proliferation-Dependent Alterations of the DNA Methylation Landscape Underlie Hematopoietic Stem Cell Aging. Cell Stem Cell 2013, 12: 413-425. PMID: 23415915, DOI: 10.1016/j.stem.2013.01.017.Peer-Reviewed Original ResearchConceptsDNA methylationHSC declineHematopoietic stem cell agingPolycomb repressive complex 2DNA methylation landscapeStem cell agingStem cell declineRepressive complex 2Global DNA methylationSite-specific alterationsHematopoietic lineage potentialMethylation landscapeDNA methylomeGenomic regionsLineage potentialEpigenomic alterationsDNA hypermethylationReplicative limitCell agingDownstream progenitorsFunctional analysisFunctional potentialMethylationProliferation of HSCsGenesThe simplest explanation: passive DNA demethylation in PGCs
Smith ZD, Meissner A. The simplest explanation: passive DNA demethylation in PGCs. The EMBO Journal 2013, 32: 318-321. PMID: 23299938, PMCID: PMC3567498, DOI: 10.1038/emboj.2012.349.Peer-Reviewed Original Research
2010
Dynamic single-cell imaging of direct reprogramming reveals an early specifying event
Smith ZD, Nachman I, Regev A, Meissner A. Dynamic single-cell imaging of direct reprogramming reveals an early specifying event. Nature Biotechnology 2010, 28: 521-526. PMID: 20436460, PMCID: PMC2908494, DOI: 10.1038/nbt.1632.Peer-Reviewed Original Research