2017
Bisphenol-A exposure in utero programs a sexually dimorphic estrogenic state of hepatic metabolic gene expression
Ilagan Y, Mamillapalli R, Goetz L, Kayani J, Taylor HS. Bisphenol-A exposure in utero programs a sexually dimorphic estrogenic state of hepatic metabolic gene expression. Reproductive Toxicology 2017, 71: 84-94. PMID: 28476547, DOI: 10.1016/j.reprotox.2017.05.001.Peer-Reviewed Original ResearchConceptsBPA exposureGene expressionAdult gene expressionFetal BPA exposureBisphenol A (BPA) exposureMetabolic gene expressionEstrogen receptor alphaExpression of genesBeta gene expressionEstrogenic stateEstrogen treatmentPregnant miceMetabolic disordersE2 stimulationReceptor alphaFetal developmentLipid metabolismDay 9Developmental programmingSexual dimorphismFemale offspringLiverObesityGenesAdult responses
2016
Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk
Fischer C, Mamillapalli R, Goetz T, Jorgenson E, Ilagan Y, Taylor HS. Bisphenol A (BPA) Exposure In Utero Leads to Immunoregulatory Cytokine Dysregulation in the Mouse Mammary Gland: A Potential Mechanism Programming Breast Cancer Risk. Discover Oncology 2016, 7: 241-251. PMID: 26911702, PMCID: PMC10726733, DOI: 10.1007/s12672-016-0254-5.Peer-Reviewed Original ResearchConceptsBPA exposureBreast cancerAdaptive immunityMammary glandPosterior mammary glandsTh1 T cellsAberrant immune responseAbnormal mammary gland developmentHuman breast cancerPossible environmental etiologyInterleukin-1 gene familyMammary gland developmentMouse mammary tissueCytolytic CD8Osmotic minipumpsCD1 miceT cellsImmune responseGene familyExpression of membersCXC familyMammary tissueDevelopmental programmingUteroWestern blot