2023
Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi–Goutières syndrome SAMHD1 dNTPase ortholog
Maehigashi T, Lim C, Wade L, Bowen N, Knecht K, Alvarez N, Kelly W, Schinazi R, Kim D, Xiong Y, Kim B. Biochemical functions and structure of Caenorhabditis elegans ZK177.8 protein: Aicardi–Goutières syndrome SAMHD1 dNTPase ortholog. Journal Of Biological Chemistry 2023, 299: 105148. PMID: 37567474, PMCID: PMC10485159, DOI: 10.1016/j.jbc.2023.105148.Peer-Reviewed Original ResearchSterile alpha motif (SAM) domainMotif domainHistidine-aspartate domain-containing protein 1Allosteric regulatory mechanismsDomain-containing protein 1Cellular dNTP levelsStriking conservationCaenorhabditis elegansBiochemical functionsDevelopmental roleGene knockdownRegulatory mechanismsDevelopmental defectsHuman monocytic cell lineDNTP levelsMonocytic cell lineMouse SAMHD1Aicardi-Goutières syndromeProtein 1OrthologsHIV-1 restriction factorsProteinCell linesRestriction factorsDNA building blocks
2016
The Role of UAF1 in the Fanconi Anemia Pathway Regulation of Homologous Recombination-Mediated Genome Maintenance
Liang F, Longerich S, Tang C, Buzovestsky O, Xiong Y, Maranon D, Wiese C, Miller A, Sung P, Kupfer G. The Role of UAF1 in the Fanconi Anemia Pathway Regulation of Homologous Recombination-Mediated Genome Maintenance. Blood 2016, 128: 1041. DOI: 10.1182/blood.v128.22.1041.1041.Peer-Reviewed Original ResearchHomologous recombinationGenome maintenanceDNA damageFA DNA repair pathwayCancer-prone genetic diseasesFanconi anemiaDNA damage hypersensitivityFunctional synergySynaptic complex assemblyProtein complex formationRad51 presynaptic filamentD-loop reactionDNA repair functionDNA damage repairDNA binding activityCell linesFANCD2 ubiquitinationGenome stabilityComplex formationRAD51 recombinaseHuman cell linesBinds DNAPresynaptic filamentRecombinase RAD51UAF1