2012
The E6AP E3 ubiquitin ligase regulates the cellular response to oxidative stress
Wolyniec K, Levav-Cohen Y, Jiang Y, Haupt S, Haupt Y. The E6AP E3 ubiquitin ligase regulates the cellular response to oxidative stress. Oncogene 2012, 32: 3510-3519. PMID: 22986523, DOI: 10.1038/onc.2012.365.Peer-Reviewed Original ResearchConceptsE3 ubiquitin ligaseReactive oxygen speciesUbiquitin ligaseStress responseCellular responsesE6AP expressionStress conditionsImportant stress conditionsCell growthCellular stress responseAppropriate cellular responsesOxidative stress responseSpecific stress conditionsOxidative stressIntracellular reactive oxygen speciesOncogenic RasCellular senescenceGrowth-suppressive effectsOxidative DNA damageApoptotic responseNovel roleCell deathImportant regulatorE6APDNA damage
2011
E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts
Levav-Cohen Y, Wolyniec K, Alsheich-Bartok O, Chan A, Woods S, Jiang Y, Haupt S, Haupt Y. E6AP is required for replicative and oncogene-induced senescence in mouse embryo fibroblasts. Oncogene 2011, 31: 2199-2209. PMID: 21927031, DOI: 10.1038/onc.2011.402.Peer-Reviewed Original ResearchConceptsMouse embryo fibroblastsOncogene-induced senescenceCellular responsesEmbryo fibroblastsCellular stress responseRas-induced senescenceE3 ubiquitin ligaseStress-induced accumulationRole of E6APUbiquitin ligaseProtein regulatorsTissue homeostasisReplicative senescenceCellular senescenceCell cycleStress responseImportant regulatorSenescenceStress conditionsE6APIndependent growthEnhanced growthEnhanced proliferationReplicativeRegulator
2009
E6AP promotes the degradation of the PML tumor suppressor
Louria-Hayon I, Alsheich-Bartok O, Levav-Cohen Y, Silberman I, Berger M, Grossman T, Matentzoglu K, Jiang Y, Muller S, Scheffner M, Haupt S, Haupt Y. E6AP promotes the degradation of the PML tumor suppressor. Cell Death & Differentiation 2009, 16: 1156-1166. PMID: 19325566, DOI: 10.1038/cdd.2009.31.Peer-Reviewed Original ResearchConceptsPML-NBsNuclear bodiesTumor suppressorPromyelocytic leukemia (PML) tumor suppressorE3 ligase E6APPML tumor suppressorPML nuclear bodiesPML protein expressionUbiquitination assaysCertain human cancersStress signalsPML proteinImportant regulatorPML stabilityDNA damageE6APCell typesHuman cancersProtein expressionActive formNull micePhysiological levelsSuppressorGrowth inhibitionPML