2008
Vascular biology and pathobiology of the liver: Report of a single‐topic symposium
Iwakiri Y, Grisham M, Shah V. Vascular biology and pathobiology of the liver: Report of a single‐topic symposium. Hepatology 2008, 47: 1754-1763. PMID: 18393322, PMCID: PMC2724750, DOI: 10.1002/hep.22203.BooksConceptsPortal hypertensionVascular biologyIschemia-reperfusion injurySingle Topic ConferenceMajority of morbidityClinical sequelaeIR injurySpecific disease syndromesLiver diseaseVascular syndromesVascular diseaseVascular cell signalingHypertensionDisease syndromeLiver cellsSyndromeMajor vascular defectsLiverVascular defectsInjuryDiseasePathobiologyAmerican AssociationCell signalingCirrhosis
2005
Akt1/protein kinase Bα is critical for ischemic and VEGF-mediated angiogenesis
Ackah E, Yu J, Zoellner S, Iwakiri Y, Skurk C, Shibata R, Ouchi N, Easton RM, Galasso G, Birnbaum MJ, Walsh K, Sessa WC. Akt1/protein kinase Bα is critical for ischemic and VEGF-mediated angiogenesis. Journal Of Clinical Investigation 2005, 115: 2119-2127. PMID: 16075056, PMCID: PMC1180542, DOI: 10.1172/jci24726.Peer-Reviewed Original ResearchConceptsSerine-threonine protein kinaseAkt1/protein kinase BαProtein kinase BαProtein kinase BAkt1-/- miceIndividual Akt isoformsLoss of Akt1Substrate phosphorylationCellular functionsAkt substrateProtein kinaseAkt isoformsAkt1 knockout miceGene expressionGenetic lossKinase BBasal phosphorylationCell metabolismPostnatal angiogenesisCellular migrationVivo roleCell migrationAKT1Essential rolePhosphorylation