2015
Nitric oxide in liver diseases
Iwakiri Y, Kim MY. Nitric oxide in liver diseases. Trends In Pharmacological Sciences 2015, 36: 524-536. PMID: 26027855, PMCID: PMC4532625, DOI: 10.1016/j.tips.2015.05.001.BooksConceptsLiver sinusoidal endothelial cellsEndothelial NO synthaseLiver diseaseNitric oxideSinusoidal endothelial cellsInducible NOSNO synthaseEndothelial cellsPathological processesDiseaseDisease developmentLiverFatty acidsS-guanylationComplicated rolePathophysiologyPathogenesisNOSProgressionImportant role
2006
Mild increases in portal pressure upregulate vascular endothelial growth factor and endothelial nitric oxide synthase in the intestinal microcirculatory bed, leading to a hyperdynamic state
Abraldes JG, Iwakiri Y, Loureiro-Silva M, Haq O, Sessa WC, Groszmann RJ. Mild increases in portal pressure upregulate vascular endothelial growth factor and endothelial nitric oxide synthase in the intestinal microcirculatory bed, leading to a hyperdynamic state. AJP Gastrointestinal And Liver Physiology 2006, 290: g980-g987. PMID: 16603731, DOI: 10.1152/ajpgi.00336.2005.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsAnimalsEndothelium, VascularHypertension, PortalIndolesIntestinal MucosaIntestinesJejunumMaleMicrocirculationNeovascularization, PathologicNitric Oxide SynthaseNitric Oxide Synthase Type IIIPortal PressurePyrrolesRatsUp-RegulationVascular Endothelial Growth Factor AVasodilationConceptsEndothelial NO synthasePortal hypertensionPortal vein ligationHyperdynamic circulationPortal pressureENOS expressionMild increaseVEGF expressionUpregulates Vascular Endothelial Growth FactorNitric oxideEndothelial nitric oxide synthaseAdvanced portal hypertensionVascular endothelial growth factorNitric oxide synthaseEndothelial growth factorInhibition of VEGFHyperdynamic statePVL ratsSplanchnic hemodynamicsIntestinal microcirculationPortosystemic shuntingVein ligationSham ratsOxide synthaseNO synthase
2002
Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension
Iwakiri Y, Cadelina G, Sessa WC, Groszmann RJ. Mice with targeted deletion of eNOS develop hyperdynamic circulation associated with portal hypertension. AJP Gastrointestinal And Liver Physiology 2002, 283: g1074-g1081. PMID: 12381520, DOI: 10.1152/ajpgi.00145.2002.Peer-Reviewed Original ResearchConceptsPartial portal vein ligationEndothelial NO synthaseHyperdynamic circulatory statePortal hypertensive animalsHyperdynamic circulationPortal hypertensionCirculatory stateHypertensive animalsInducible NOSNitric oxideLevels of vasodilatorsPortal vein ligationSham-operated groupSham-operated animalsSystemic vasodilationSplanchnic circulationPeripheral resistanceVein ligationSham animalsNO synthaseKnockout miceGene deletionINOS geneHemodynamic characteristicsMice