2008
Urocortin2 inhibits tumor growth via effects on vascularization and cell proliferation
Hao Z, Huang Y, Cleman J, Jovin IS, Vale WW, Bale TL, Giordano FJ. Urocortin2 inhibits tumor growth via effects on vascularization and cell proliferation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2008, 105: 3939-3944. PMID: 18308934, PMCID: PMC2268793, DOI: 10.1073/pnas.0712366105.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarcinoma, Lewis LungCell ProliferationGene Expression Regulation, NeoplasticMaleMiceMice, Inbred C57BLNeovascularization, PathologicReceptors, Corticotropin-Releasing HormoneUrocortinsConceptsInhibits tumor growthTumor growthTumor vascularizationActivation of CRFR2Potential therapeutic roleTumor growth inhibitionTumor-suppressing effectsCRFR2 activationMeasurable tumorsTumor cell cyclingCell tumorsTherapeutic roleClinical malignancyUrocortin 2Peripheral tissuesCRFR2Ucn2Genetic deletionTissue vascularityDirect inhibitionVessel diameterCell proliferationVessel numberVascularizationTumors
2002
Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization
Bale TL, Giordano FJ, Hickey RP, Huang Y, Nath AK, Peterson KL, Vale WW, Lee KF. Corticotropin-releasing factor receptor 2 is a tonic suppressor of vascularization. Proceedings Of The National Academy Of Sciences Of The United States Of America 2002, 99: 7734-7739. PMID: 12032352, PMCID: PMC124337, DOI: 10.1073/pnas.102187099.Peer-Reviewed Original ResearchMeSH KeywordsAngiogenesis InhibitorsAnimalsCapillariesCell DivisionCells, CulturedEndothelial Growth FactorsEndothelium, VascularGene Expression RegulationLymphokinesMiceMice, KnockoutMuscle, Smooth, VascularNeovascularization, PhysiologicReceptors, Corticotropin-Releasing HormoneVascular Endothelial Growth Factor AVascular Endothelial Growth FactorsConceptsCorticotropin-releasing factor receptor 2Smooth muscle cellsCapillary tube formationTube formationCell cycle progressionVascular endothelial growth factorFactor receptor 2Protein phosphorylationRetinoblastoma proteinCycle progressionLigand activationReceptor 2Adult neovascularizationCRFR2-deficient miceCell proliferationIschemic cardiovascular diseasePotential targetAdult vesselsQuiescent stateMuscle cellsEndothelial growth factorGrowth factorSMC proliferationWestern blotCollagen gels