Featured Publications
Inhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen
Pedersen SF, Collora JA, Kim RN, Yang K, Razmi A, Catalano AA, Yeh YJ, Mounzer K, Tebas P, Montaner LJ, Ho YC. Inhibition of a Chromatin and Transcription Modulator, SLTM, Increases HIV-1 Reactivation Identified by a CRISPR Inhibition Screen. Journal Of Virology 2022, 96: e00577-22. PMID: 35730977, PMCID: PMC9278143, DOI: 10.1128/jvi.00577-22.Peer-Reviewed Original ResearchConceptsHIV-1-infected cellsHIV-1 reactivationT cell clonesHIV-1HIV-1 protein expressionAntiretroviral therapyDrug treatmentProtein expressionInfected cellsInfected individualsHIV-1-infected individualsCell clonesEffective antiretroviral therapyHIV-1 cureLong-term therapyHIV-1 gene expressionHIV-1 persistenceHIV-1 provirusHIV-1 transcriptionImmune cell killingNovel therapeutic targetCell deathLatent reservoirImmune cellsT cells
2020
The forces driving clonal expansion of the HIV-1 latent reservoir
Liu R, Simonetti FR, Ho YC. The forces driving clonal expansion of the HIV-1 latent reservoir. Virology Journal 2020, 17: 4. PMID: 31910871, PMCID: PMC6947923, DOI: 10.1186/s12985-019-1276-8.Peer-Reviewed Original ResearchConceptsHIV-1-infected cellsHIV-1 latent reservoirLatent reservoirAntiretroviral therapyClonal expansionViral reboundHomeostatic proliferationAntigen-specific CD4HIV-1 eradicationHIV-1 replicationT cell functionHIV-1 provirusCertain cancer-related genesCytokine profileAntigen exposureViral loadExhaustion phenotypeLymphoid tissueT cellsClonal expansion dynamicsImmune clearanceCancer-related genesViral expressionCell functionUndetectable levels
2017
Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape
Pollack RA, Jones RB, Pertea M, Bruner KM, Martin AR, Thomas AS, Capoferri AA, Beg SA, Huang SH, Karandish S, Hao H, Halper-Stromberg E, Yong PC, Kovacs C, Benko E, Siliciano RF, Ho YC. Defective HIV-1 Proviruses Are Expressed and Can Be Recognized by Cytotoxic T Lymphocytes, which Shape the Proviral Landscape. Cell Host & Microbe 2017, 21: 494-506.e4. PMID: 28407485, PMCID: PMC5433942, DOI: 10.1016/j.chom.2017.03.008.Peer-Reviewed Original ResearchConceptsCytotoxic T lymphocytesHIV-1 provirusT lymphocytesHIV-1-specific cytotoxic T lymphocytesDefective provirusesHIV-1-infected individualsDefective HIV-1 provirusesHIV-1 latency reversalMajor splice donorHIV-1 transcriptsAntiretroviral therapyMemory CD4Latency reversalCTL epitopesHIV-1Proviral landscapeLymphocytesProvirusCellsNovel splice siteAberrant translationCD4Therapy