2024
Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic
Faust J, Renton B, Bongiovanni T, Chen A, Sheares K, Du C, Essien U, Fuentes-Afflick E, Haywood T, Khera R, King T, Li S, Lin Z, Lu Y, Marshall A, Ndumele C, Opara I, Loarte-Rodriguez T, Sawano M, Taparra K, Taylor H, Watson K, Yancy C, Krumholz H. Racial and Ethnic Disparities in Age-Specific All-Cause Mortality During the COVID-19 Pandemic. JAMA Network Open 2024, 7: e2438918. PMID: 39392630, DOI: 10.1001/jamanetworkopen.2024.38918.Peer-Reviewed Original ResearchConceptsCOVID-19 public health emergencyNon-HispanicPublic health emergencyOther Pacific IslanderExcess mortalityAlaska NativesUS populationExcess deathsRates of excess mortalityCross-sectional study analyzed dataYears of potential lifeMortality relative riskNon-Hispanic whitesCross-sectional studyPacific IslandersStudy analyzed dataAll-cause mortalityEthnic groupsMortality disparitiesMortality ratioTotal populationDeath certificatesEthnic disparitiesMain OutcomesDecedent ageCause-Specific Mortality Rates Among the US Black Population
Arun A, Caraballo C, Sawano M, Lu Y, Khera R, Yancy C, Krumholz H. Cause-Specific Mortality Rates Among the US Black Population. JAMA Network Open 2024, 7: e2436402. PMID: 39348122, PMCID: PMC11443349, DOI: 10.1001/jamanetworkopen.2024.36402.Peer-Reviewed Original Research
2023
Quantifying Blood Pressure Visit-to-Visit Variability in the Real-World Setting: A Retrospective Cohort Study
Lu Y, Linderman G, Mahajan S, Liu Y, Huang C, Khera R, Mortazavi B, Spatz E, Krumholz H. Quantifying Blood Pressure Visit-to-Visit Variability in the Real-World Setting: A Retrospective Cohort Study. Circulation Cardiovascular Quality And Outcomes 2023, 16: e009258. PMID: 36883456, DOI: 10.1161/circoutcomes.122.009258.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyBlood pressure valuesPatient characteristicsReal-world settingCohort studyPatient subgroupsYale New Haven Health SystemMean body mass indexSystolic blood pressure valuesBlood pressure visitHistory of hypertensionCoronary artery diseaseManagement of patientsMultivariable linear regression modelsBlood pressure readingsBody mass indexPatient-level measuresBlood pressure variationAbsolute standardized differencesNon-Hispanic whitesAntihypertensive medicationsReal-world practiceVisit variabilityArtery diseaseRegression models
2022
Temporal Trends in Racial and Ethnic Disparities in Multimorbidity Prevalence in the United States, 1999-2018
Caraballo C, Herrin J, Mahajan S, Massey D, Lu Y, Ndumele CD, Drye EE, Krumholz HM. Temporal Trends in Racial and Ethnic Disparities in Multimorbidity Prevalence in the United States, 1999-2018. The American Journal Of Medicine 2022, 135: 1083-1092.e14. PMID: 35472394, DOI: 10.1016/j.amjmed.2022.04.010.Peer-Reviewed Original ResearchConceptsMultimorbidity prevalenceRace/ethnicityWhite individualsChronic conditionsBlack individualsSerial cross-sectional analysisCommon chronic conditionsRisk of morbidityPrevalence of multimorbidityPublic health interventionsCross-sectional analysisSelf-reported presenceSelf-reported raceLatino/HispanicMAIN OUTCOMEHealth interventionsEthnic disparitiesPrevalenceHealth inequalitiesStudy periodEarly lifeHispanic individualsTemporal trendsStudy sampleAsian individualsAnalysis of Dual Combination Therapies Used in Treatment of Hypertension in a Multinational Cohort
Lu Y, Van Zandt M, Liu Y, Li J, Wang X, Chen Y, Chen Z, Cho J, Dorajoo SR, Feng M, Hsu MH, Hsu JC, Iqbal U, Jonnagaddala J, Li YC, Liaw ST, Lim HS, Ngiam KY, Nguyen PA, Park RW, Pratt N, Reich C, Rhee SY, Sathappan SMK, Shin SJ, Tan HX, You SC, Zhang X, Krumholz HM, Suchard MA, Xu H. Analysis of Dual Combination Therapies Used in Treatment of Hypertension in a Multinational Cohort. JAMA Network Open 2022, 5: e223877. PMID: 35323951, PMCID: PMC8948532, DOI: 10.1001/jamanetworkopen.2022.3877.Peer-Reviewed Original ResearchConceptsDual combination therapyUse of ACEIAntihypertensive drug classesProportion of patientsKhoo Teck Puat HospitalCombination therapyUniversity Hospital databaseHospital databaseDrug classesDual combinationSouth Western Sydney Local Health DistrictWestern Sydney Local Health DistrictPatients age 65 yearsSydney Local Health DistrictElectronic health record databasePatients age 18Local Health DistrictAge 65 yearsTreatment of hypertensionHealth record databaseARB monotherapyTreatment escalationAdult patientsCohort studyCombination regimen
2021
Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial
Wang L, Lu Y, Wang H, Gu J, J Z, Lian Z, Zhang Z, Krumholz H, Sun N. Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial. Open Heart 2021, 8: e001719. PMID: 34580169, PMCID: PMC8477318, DOI: 10.1136/openhrt-2021-001719.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntihypertensive AgentsBlood PressureCardiography, ImpedanceChinaClinical Decision-MakingFemaleFollow-Up StudiesHumansHypertensionIncidenceMaleMiddle AgedPractice Guidelines as TopicRetrospective StudiesTherapy, Computer-AssistedTime FactorsTreatment OutcomeYoung AdultConceptsBody mass indexPeking University People's HospitalStandard care groupBlood pressure controlSystolic BPHaemodynamic groupsTreatment strategiesImpedance cardiographyBaseline BPBP goalHypertension clinicHaemodynamic profileBP levelsCare groupPeople's HospitalMean baseline systolic BPPressure controlReal-world clinical practiceBaseline systolic BPMean systolic BPDiastolic BP levelsProportion of patientsPragmatic clinical trialsReal-world populationBaseline DBP
2017
Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults
Abarca-Gómez L, Abdeen Z, Hamid Z, Abu-Rmeileh N, Acosta-Cazares B, Acuin C, Adams R, Aekplakorn W, Afsana K, Aguilar-Salinas C, Agyemang C, Ahmadvand A, Ahrens W, Ajlouni K, Akhtaeva N, Al-Hazzaa H, Al-Othman A, Al-Raddadi R, Al Buhairan F, Al Dhukair S, Ali M, Ali O, Alkerwi A, Alvarez-Pedrerol M, Aly E, Amarapurkar D, Amouyel P, Amuzu A, Andersen L, Anderssen S, Andrade D, Ängquist L, Anjana R, Aounallah-Skhiri H, Araújo J, Ariansen I, Aris T, Arlappa N, Arveiler D, Aryal K, Aspelund T, Assah F, Assunção M, Aung M, Avdicová M, Azevedo A, Azizi F, Babu B, Bahijri S, Baker J, Balakrishna N, Bamoshmoosh M, Banach M, Bandosz P, Banegas J, Barbagallo C, Barceló A, Barkat A, Barros A, Barros M, Bata I, Batieha A, Batista R, Batyrbek A, Baur L, Beaglehole R, Romdhane H, Benedics J, Benet M, Bennett J, Bernabe-Ortiz A, Bernotiene G, Bettiol H, Bhagyalaxmi A, Bharadwaj S, Bhargava S, Bhatti Z, Bhutta Z, Bi H, Bi Y, Biehl A, Bikbov M, Bista B, Bjelica D, Bjerregaard P, Bjertness E, Bjertness M, Björkelund C, Blokstra A, Bo S, Bobak M, Boddy L, Boehm B, Boeing H, Boggia J, Boissonnet C, Bonaccio M, Bongard V, Bovet P, Braeckevelt L, Braeckman L, Bragt M, Brajkovich I, Branca F, Breckenkamp J, Breda J, Brenner H, Brewster L, Brian G, Brinduse L, Bruno G, Bueno-de-Mesquita H, Bugge A, Buoncristiano M, Burazeri G, Burns C, de León A, Cacciottolo J, Cai H, Cama T, Cameron C, Camolas J, Can G, Cândido A, Capanzana M, Capuano V, Cardoso V, Carlsson A, Carvalho M, Casanueva F, Casas J, Caserta C, Chamukuttan S, Chan A, Chan Q, Chaturvedi H, Chaturvedi N, Chen C, Chen F, Chen H, Chen S, Chen Z, Cheng C, Chetrit A, Chikova-Iscener E, Chiolero A, Chiou S, Chirita-Emandi A, Chirlaque M, Cho B, Cho Y, Christensen K, Christofaro D, Chudek J, Cifkova R, Cinteza E, Claessens F, Clays E, Concin H, Confortin S, Cooper C, Cooper R, Coppinger T, Costanzo S, Cottel D, Cowell C, Craig C, Crujeiras A, Cucu A, D'Arrigo G, d'Orsi E, Dallongeville J, Damasceno A, Damsgaard C, Danaei G, Dankner R, Dantoft T, Dastgiri S, Dauchet L, Davletov K, De Backer G, De Bacquer D, De Curtis A, de Gaetano G, De Henauw S, de Oliveira P, De Ridder K, De Smedt D, Deepa M, Deev A, Dehghan A, Delisle H, Delpeuch F, Deschamps V, Dhana K, Di Castelnuovo A, Dias-da-Costa J, Diaz A, Dika Z, Djalalinia S, Do H, Dobson A, Donati M, Donfrancesco C, Donoso S, Döring A, Dorobantu M, Dorosty A, Doua K, Drygas W, Duan J, Duante C, Duleva V, Dulskiene V, Dzerve V, Dziankowska-Zaborszczyk E, Egbagbe E, Eggertsen R, Eiben G, Ekelund U, El Ati J, Elliott P, Engle-Stone R, Erasmus R, Erem C, Eriksen L, Eriksson J, la Peña J, Evans A, Faeh D, Fall C, Sant'Angelo V, Farzadfar F, Felix-Redondo F, Ferguson T, Fernandes R, Fernández-Bergés D, Ferrante D, Ferrari M, Ferreccio C, Ferrieres J, Finn J, Fischer K, Flores E, Föger B, Foo L, Forslund A, Forsner M, Fouad H, Francis D, Franco M, Franco O, Frontera G, Fuchs F, Fuchs S, Fujita Y, Furusawa T, Gaciong Z, Gafencu M, Galeone D, Galvano F, Garcia-de-la-Hera M, Gareta D, Garnett S, Gaspoz J, Gasull M, Gates L, Geiger H, Geleijnse J, Ghasemian A, Giampaoli S, Gianfagna F, Gill T, Giovannelli J, Giwercman A, Godos J, Gogen S, Goldsmith R, Goltzman D, Gonçalves H, González-Leon M, González-Rivas J, Gonzalez-Gross M, Gottrand F, Graça A, Graff-Iversen S, Grafnetter D, Grajda A, Grammatikopoulou M, Gregor R, Grodzicki T, Grøntved A, Grosso G, Gruden G, Grujic V, Gu D, Gualdi-Russo E, Guallar-Castillón P, Guan O, Gudmundsson E, Gudnason V, Guerrero R, Guessous I, Guimaraes A, Gulliford M, Gunnlaugsdottir J, Gunter M, Guo X, Guo Y, Gupta P, Gupta R, Gureje O, Gurzkowska B, Gutierrez L, Gutzwiller F, Hadaegh F, Hadjigeorgiou C, Si-Ramlee K, Halkjær J, Hambleton I, Hardy R, Kumar R, Hassapidou M, Hata J, Hayes A, He J, Heidinger-Felso R, Heinen M, Hendriks M, Henriques A, Cadena L, Herrala S, Herrera V, Herter-Aeberli I, Heshmat R, Hihtaniemi I, Ho S, Ho S, Hobbs M, Hofman A, Hopman W, Horimoto A, Hormiga C, Horta B, Houti L, Howitt C, Htay T, Htet A, Htike M, Hu Y, Huerta J, Petrescu C, Huisman M, Husseini A, Huu C, Huybrechts I, Hwalla N, Hyska J, Iacoviello L, Iannone A, Ibarluzea J, Ibrahim M, Ikeda N, Ikram M, Irazola V, Islam M, Ismail A, Ivkovic V, Iwasaki M, Jackson R, Jacobs J, Jaddou H, Jafar T, Jamil K, Jamrozik K, Janszky I, Jarani J, Jasienska G, Jelakovic A, Jelakovic B, Jennings G, Jeong S, Jiang C, Jiménez-Acosta S, Joffres M, Johansson M, Jonas J, Jørgensen T, Joshi P, Jovic D, Józwiak J, Juolevi A, Jurak G, Jureša V, Kaaks R, Kafatos A, Kajantie E, Kalter-Leibovici O, Kamaruddin N, Kapantais E, Karki K, Kasaeian A, Katz J, Kauhanen J, Kaur P, Kavousi M, Kazakbaeva G, Keil U, Boker L, Keinänen-Kiukaanniemi S, Kelishadi R, Kelleher C, Kemper H, Kengne A, Kerimkulova A, Kersting M, Key T, Khader Y, Khalili D, Khang Y, Khateeb M, Khaw K, Khouw I, Kiechl-Kohlendorfer U, Kiechl S, Killewo J, Kim J, Kim Y, Klimont J, Klumbiene J, Knoflach M, Koirala B, Kolle E, Kolsteren P, Korrovits P, Kos J, Koskinen S, Kouda K, Kovacs V, Kowlessur S, Koziel S, Kratzer W, Kriemler S, Kristensen P, Krokstad S, Kromhout D, Kruger H, Kubinova R, Kuciene R, Kuh D, Kujala U, Kulaga Z, Kumar R, Kunešová M, Kurjata P, Kusuma Y, Kuulasmaa K, Kyobutungi C, La Q, Laamiri F, Laatikainen T, Lachat C, Laid Y, Lam T, Landrove O, Lanska V, Lappas G, Larijani B, Laugsand L, Lauria L, Laxmaiah A, Bao K, Le T, Lebanan M, Leclercq C, Lee J, Lee J, Lehtimäki T, León-Muñoz L, Levitt N, Li Y, Lilly C, Lim W, Lima-Costa M, Lin H, Lin X, Lind L, Linneberg A, Lissner L, Litwin M, Liu J, Loit H, Lopes L, Lorbeer R, Lotufo P, Lozano J, Luksiene D, Lundqvist A, Lunet N, Lytsy P, Ma G, Ma J, Machado-Coelho G, Machado-Rodrigues A, Machi S, Maggi S, Magliano D, Magriplis E, Mahaletchumy A, Maire B, Majer M, Makdisse M, Malekzadeh R, Malhotra R, Rao K, Malyutina S, Manios Y, Mann J, Manzato E, Margozzini P, Markaki A, Markey O, Marques L, Marques-Vidal P, Marrugat J, Martin-Prevel Y, Martin R, Martorell R, Martos E, Marventano S, Masoodi S, Mathiesen E, Matijasevich A, Matsha T, Mazur A, Mbanya J, McFarlane S, McGarvey S, McKee M, McLachlan S, McLean R, McLean S, McNulty B, Yusof S, Mediene-Benchekor S, Medzioniene J, Meirhaeghe A, Meisfjord J, Meisinger C, Menezes A, Menon G, Mensink G, Meshram I, Metspalu A, Meyer H, Mi J, Michaelsen K, Michels N, Mikkel K, Miller J, Minderico C, Miquel J, Miranda J, Mirkopoulou D, Mirrakhimov E, Mišigoj-Durakovic M, Mistretta A, Mocanu V, Modesti P, Mohamed M, Mohammad K, Mohammadifard N, Mohan V, Mohanna S, Yusoff M, Molbo D, Møllehave L, Møller N, Molnár D, Momenan A, Mondo C, Monterrubio E, Monyeki K, Moon J, Moreira L, Morejon A, Moreno L, Morgan K, Mortensen E, Moschonis G, Mossakowska M, Mostafa A, Mota J, Mota-Pinto A, Motlagh M, Motta J, Mu T, Muc M, Muiesan M, Müller-Nurasyid M, Murphy N, Mursu J, Murtagh E, Musil V, Nabipour I, Nagel G, Naidu B, Nakamura H, Námešná J, Nang E, Nangia V, Nankap M, Narake S, Nardone P, Navarrete-Muñoz E, Neal W, Nenko I, Neovius M, Nervi F, Nguyen C, Nguyen N, Nguyen Q, Nieto-Martínez R, Ning G, Ninomiya T, Nishtar S, Noale M, Noboa O, Norat T, Norie S, Noto D, Nsour M, O'Reilly D, Obreja G, Oda E, Oehlers G, Oh K, Ohara K, Olafsson Ö, Olinto M, Oliveira I, Oltarzewski M, Omar M, Onat A, Ong S, Ono L, Ordunez P, Ornelas R, Ortiz A, Osler M, Osmond C, Ostojic S, Ostovar A, Otero J, Overvad K, Owusu-Dabo E, Paccaud F, Padez C, Pahomova E, Pajak A, Palli D, Palloni A, Palmieri L, Pan W, Panda-Jonas S, Pandey A, Panza F, Papandreou D, Park S, Parnell W, Parsaeian M, Pascanu I, Patel N, Pecin I, Pednekar M, Peer N, Peeters P, Peixoto S, Peltonen M, Pereira A, Perez-Farinos N, Pérez C, Peters A, Petkeviciene J, Petrauskiene A, Peykari N, Pham S, Pierannunzio D, Pigeot I, Pikhart H, Pilav A, Pilotto L, Pistelli F, Pitakaka F, Piwonska A, Plans-Rubió P, Poh B, Pohlabeln H, Pop R, Popovic S, Porta M, Portegies M, Posch G, Poulimeneas D, Pouraram H, Pourshams A, Poustchi H, Pradeepa R, Prashant M, Price J, Puder J, Pudule I, Puiu M, Punab M, Qasrawi R, Qorbani M, Bao T, Radic I, Radisauskas R, Rahman M, Rahman M, Raitakari O, Raj M, Rao S, Ramachandran A, Ramke J, Ramos E, Ramos R, Rampal L, Rampal S, Rascon-Pacheco R, Redon J, Reganit P, Ribas-Barba L, Ribeiro R, Riboli E, Rigo F, de Wit T, Rito A, Ritti-Dias R, Rivera J, Robinson S, Robitaille C, Rodrigues D, Rodríguez-Artalejo F, del Cristo Rodriguez-Perez M, Rodríguez-Villamizar L, Rojas-Martinez R, Rojroongwasinkul N, Romaguera D, Ronkainen K, Rosengren A, Rouse I, Roy J, Rubinstein A, Rühli F, Ruiz-Betancourt B, Russo P, Rutkowski M, Sabanayagam C, Sachdev H, Saidi O, Salanave B, Martinez E, Salmerón D, Salomaa V, Salonen J, Salvetti M, Sánchez-Abanto J, Sandjaja, Sans S, Marina L, Santos D, Santos I, Santos O, dos Santos R, Santos R, Saramies J, Sardinha L, Sarrafzadegan N, Saum K, Savva S, Savy M, Scazufca M, Rosario A, Schargrodsky H, Schienkiewitz A, Schipf S, Schmidt C, Schmidt I, Schultsz C, Schutte A, Sein A, Sen A, Senbanjo I, Sepanlou S, Serra-Majem L, Shalnova S, Sharma S, Shaw J, Shibuya K, Shin D, Shin Y, Shiri R, Siani A, Siantar R, Sibai A, Silva A, Silva D, Simon M, Simons J, Simons L, Sjöberg A, Sjöström M, Skovbjerg S, Slowikowska-Hilczer J, Slusarczyk P, Smeeth L, Smith M, Snijder M, So H, Sobngwi E, Söderberg S, Soekatri M, Solfrizzi V, Sonestedt E, Song Y, Sørensen T, Soric M, Jérome C, Soumare A, Spinelli A, Spiroski I, Staessen J, Stamm H, Starc G, Stathopoulou M, Staub K, Stavreski B, Steene-Johannessen J, Stehle P, Stein A, Stergiou G, Stessman J, Stieber J, Stöckl D, Stocks T, Stokwiszewski J, Stratton G, Stronks K, Strufaldi M, Suárez-Medina R, Sun C, Sundström J, Sung Y, Sunyer J, Suriyawongpaisal P, Swinburn B, Sy R, Szponar L, Tai E, Tammesoo M, Tamosiunas A, Tan E, Tang X, Tanser F, Tao Y, Tarawneh M, Tarp J, Tarqui-Mamani C, Tautu O, Braunerová R, Taylor A, Tchibindat F, Theobald H, Theodoridis X, Thijs L, Thuesen B, Tjonneland A, Tolonen H, Tolstrup J, Topbas M, Topór-Madry R, Tormo M, Tornaritis M, Torrent M, Toselli S, Traissac P, Trichopoulos D, Trichopoulou A, Trinh O, Trivedi A, Tshepo L, Tsigga M, Tsugane S, Tulloch-Reid M, Tullu F, Tuomainen T, Tuomilehto J, Turley M, Tynelius P, Tzotzas T, Tzourio C, Ueda P, Ugel E, Ukoli F, Ulmer H, Unal B, Uusitalo H, Valdivia G, Vale S, Valvi D, van der Schouw Y, Van Herck K, Van Minh H, van Rossem L, Van Schoor N, van Valkengoed I, Vanderschueren D, Vanuzzo D, Vatten L, Vega T, Veidebaum T, Velasquez-Melendez G, Velika B, Veronesi G, Verschuren W, Victora C, Viegi G, Viet L, Viikari-Juntura E, Vineis P, Vioque J, Virtanen J, Visvikis-Siest S, Viswanathan B, Vlasoff T, Vollenweider P, Völzke H, Voutilainen S, Vrijheid M, Wade A, Wagner A, Waldhör T, Walton J, Bebakar W, Mohamud W, Wanderley R, Wang M, Wang Q, Wang Y, Wang Y, Wannamethee S, Wareham N, Weber A, Wedderkopp N, Weerasekera D, Whincup P, Widhalm K, Widyahening I, Wiecek A, Wijga A, Wilks R, Willeit J, Willeit P, Wilsgaard T, Wojtyniak B, Wong-McClure R, Wong J, Wong J, Wong T, Woo J, Woodward M, Wu F, Wu J, Wu S, Xu H, Xu L, Yamborisut U, Yan W, Yang X, Yardim N, Ye X, Yiallouros P, Yngve A, Yoshihara A, You Q, Younger-Coleman N, Yusoff F, Yusoff M, Zaccagni L, Zafiropulos V, Zainuddin A, Zambon S, Zampelas A, Zamrazilová H, Zdrojewski T, Zeng Y, Zhao D, Zhao W, Zheng W, Zheng Y, Zholdin B, Zhou M, Zhu D, Zhussupov B, Zimmermann E, Cisneros J, Bentham J, Di Cesare M, Bilano V, Bixby H, Zhou B, Stevens G, Riley L, Taddei C, Hajifathalian K, Lu Y, Savin S, Cowan M, Paciorek C, Chirita-Emandi A, Hayes A, Katz J, Kelishadi R, Kengne A, Khang Y, Laxmaiah A, Li Y, Ma J, Miranda J, Mostafa A, Neovius M, Padez C, Rampal L, Zhu A, Bennett J, Danaei G, Bhutta Z, Ezzati M. Worldwide trends in body-mass index, underweight, overweight, and obesity from 1975 to 2016: a pooled analysis of 2416 population-based measurement studies in 128·9 million children, adolescents, and adults. The Lancet 2017, 390: 2627-2642. PMID: 29029897, PMCID: PMC5735219, DOI: 10.1016/s0140-6736(17)32129-3.Peer-Reviewed Original ResearchConceptsMean body mass indexBody mass indexPrevalence of obesitySevere underweightAge-standardised mean body mass indexPrevalence of BMIGlobal age-standardised prevalenceCentral Latin AmericaAge-standardised prevalencePopulation-based studyAdolescent body mass indexAdverse health consequencesNon-significant increaseAndean Latin AmericaBMI categoriesWHO growth referencesMeasurements of heightPooled analysisHigh-income countriesObesityUnderweightHealth programsPrevalenceHealth consequencesGrowth referencesTrends in obesity and diabetes across Africa from 1980 to 2014: an analysis of pooled population-based studies
Kengne A, Bentham J, Zhou B, Peer N, Matsha T, Bixby H, Di Cesare M, Hajifathalian K, Lu Y, Taddei C, Bovet P, Kyobutungi C, Agyemang C, Aounallah-Skhiri H, Assah F, Barkat A, Romdhane H, Chan Q, Chaturvedi N, Damasceno A, Delisle H, Delpeuch F, Doua K, Egbagbe E, Ati J, Elliott P, Engle-Stone R, Erasmus R, Fouad H, Gareta D, Gureje O, Hendriks M, Houti L, Ibrahim M, Kemper H, Killewo J, Kowlessur S, Kruger H, Laamiri F, Laid Y, Levitt N, Lunet N, Magliano D, Maire B, Martin-Prevel Y, Mediene-Benchekor S, Mohamed M, Mondo C, Monyeki K, Mostafa A, Nankap M, Owusu-Dabo E, de Wit T, Saidi O, Schultsz C, Schutte A, Senbanjo I, Shaw J, Smeeth L, Sobngwi E, Jérome C, Stronks K, Tanser F, Tchibindat F, Traissac P, Tshepo L, Tullu F, Ukoli F, Viswanathan B, Wade A, Danaei G, Stevens G, Riley L, Ezzati M, Mbanya J. Trends in obesity and diabetes across Africa from 1980 to 2014: an analysis of pooled population-based studies. International Journal Of Epidemiology 2017, 46: 1421-1432. PMID: 28582528, PMCID: PMC5837192, DOI: 10.1093/ije/dyx078.Peer-Reviewed Original ResearchConceptsMean body mass indexBody mass indexAge-standardized mean body mass indexPopulation-based studyNon-communicable diseasesWorldwide population-based studyAge-standardized prevalenceBurden of diabetesDiabetes prevalence estimatesPopulation-based surveyDiabetes statusDiabetes prevalenceMass indexControl diabetesDiabetes estimatesDiabetesPrevalence estimatesPrevalenceObesityPositive associationWomenSaharan AfricaSexMenHigher numberSex Differences in Inflammatory Markers and Health Status Among Young Adults With Acute Myocardial Infarction
Lu Y, Zhou S, Dreyer RP, Spatz ES, Geda M, Lorenze NP, D'Onofrio G, Lichtman JH, Spertus JA, Ridker PM, Krumholz HM. Sex Differences in Inflammatory Markers and Health Status Among Young Adults With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003470. PMID: 28228461, PMCID: PMC5459381, DOI: 10.1161/circoutcomes.116.003470.Peer-Reviewed Original ResearchMeSH Keywords1-Alkyl-2-acetylglycerophosphocholine EsteraseAdolescentAdultAge of OnsetBiomarkersChi-Square DistributionComorbidityC-Reactive ProteinFemaleHealth Status DisparitiesHumansInflammation MediatorsLinear ModelsMaleMiddle AgedMultivariate AnalysisMyocardial InfarctionProspective StudiesRisk AssessmentRisk FactorsSex FactorsSocioeconomic FactorsUnited StatesUp-RegulationYoung AdultConceptsHigh-sensitivity C-reactive proteinAcute myocardial infarctionHigher inflammatory levelsInflammatory markersPoor health statusHealth statusYoung womenMyocardial infarctionInflammatory levelsTargeted anti-inflammatory treatmentsElevated inflammatory markersResidual cholesterol riskResidual inflammatory riskSex differencesAnti-inflammatory treatmentAnti-inflammatory therapyC-reactive proteinHigher mortality riskYoung menPhospholipase A2Years of ageCardiovascular outcomesMultivariable adjustmentPatient characteristicsSecondary prevention
2016
Sex differences in lipid profiles and treatment utilization among young adults with acute myocardial infarction: Results from the VIRGO study
Lu Y, Zhou S, Dreyer RP, Caulfield M, Spatz ES, Geda M, Lorenze NP, Herbert P, D'Onofrio G, Jackson EA, Lichtman JH, Bueno H, Spertus JA, Krumholz HM. Sex differences in lipid profiles and treatment utilization among young adults with acute myocardial infarction: Results from the VIRGO study. American Heart Journal 2016, 183: 74-84. PMID: 27979045, PMCID: PMC5459396, DOI: 10.1016/j.ahj.2016.09.012.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionLipid profileYoung womenLipoprotein cholesterolLipoprotein profileMyocardial infarctionTreatment utilizationLow-density lipoprotein cholesterolHigh-density lipoprotein cholesterolLow HDL cholesterol levelsYoung adultsHigh-intensity doseMajor lipid abnormalitiesSex differencesAdverse lipid profileFavorable lipoprotein profileHDL cholesterol ratioLower total cholesterolHDL cholesterol levelsHigher HDL cholesterolImportant risk factorHigher mortality riskMultivariate regression analysisVIRGO StudyCardiovascular outcomesTrends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants
Analysis and Writing P, Di Cesare M, Bentham J, Stevens G, Zhou B, Danaei G, Lu Y, Bixby H, Cowan M, Riley L, Hajifathalian K, Fortunato L, Taddei C, Bennett J, Ikeda N, Khang Y, Kyobutungi C, Laxmaiah A, Li Y, Lin H, Miranda J, Mostafa A, Turley M, Paciorek C, Gunter M, Ezzati M, Data C, Abdeen Z, Hamid Z, Abu-Rmeileh N, Acosta-Cazares B, Adams R, Aekplakorn W, Aguilar-Salinas C, Ahmadvand A, Ahrens W, Ali M, Alkerwi A, Alvarez-Pedrerol M, Aly E, Amouyel P, Amuzu A, Andersen L, Anderssen S, Andrade D, Anjana R, Aounallah-Skhiri H, Ariansen I, Aris T, Arlappa N, Arveiler D, Assah F, Avdicová M, Azizi F, Babu B, Balakrishna N, Bandosz P, Banegas J, Barbagallo C, Barceló A, Barkat A, Barros M, Bata I, Batieha A, Batista R, Baur L, Beaglehole R, Romdhane H, Benet M, Bernabe-Ortiz A, Bernotiene G, Bettiol H, Bhagyalaxmi A, Bharadwaj S, Bhargava S, Bhatti Z, Bhutta Z, Bi H, Bi Y, Bjerregaard P, Bjertness E, Bjertness M, Björkelund C, Blake M, Blokstra A, Bo S, Bobak M, Boddy L, Boehm B, Boeing H, Boissonnet C, Bongard V, Bovet P, Braeckman L, Bragt M, Brajkovich I, Branca F, Breckenkamp J, Brenner H, Brewster L, Brian G, Bruno G, Bueno-de-Mesquita H, Bugge A, Burns C, de León A, Cacciottolo J, Cama T, Cameron C, Camolas J, Can G, Cândido A, Capuano V, Cardoso V, Carvalho M, Casanueva F, Casas J, Caserta C, Castetbon K, Chamukuttan S, Chan A, Chan Q, Chaturvedi H, Chaturvedi N, Chen C, Chen F, Chen H, Chen S, Chen Z, Cheng C, Chetrit A, Chiolero A, Chiou S, Chirita-Emandi A, Cho Y, Christensen K, Chudek J, Cifkova R, Claessens F, Clays E, Concin H, Cooper C, Cooper R, Coppinger T, Costanzo S, Cottel D, Cowell C, Craig C, Crujeiras A, D’Arrigo G, d’Orsi E, Dallongeville J, Damasceno A, Damsgaard C, Danaei G, Dankner R, Dauchet L, De Backer G, De Bacquer D, de Gaetano G, De Henauw S, De Smedt D, Deepa M, Deev A, Dehghan A, Delisle H, Delpeuch F, Dhana K, Di Castelnuovo A, Dias-da-Costa J, Diaz A, Djalalinia S, P H, Dobson A, Donfrancesco C, Döring A, Doua K, Drygas W, Egbagbe E, Eggertsen R, Ekelund U, Ati J, Elliott P, Engle-Stone R, Erasmus R, Erem C, Eriksen L, la Peña J, Evans A, Faeh D, Fall C, Farzadfar F, Felix-Redondo F, Ferguson T, Fernández-Bergés D, Ferrante D, Ferrari M, Ferreccio C, Ferrieres J, Finn J, Fischer K, Flores E, Föger B, Foo L, Forslund A, Fortmann S, Fouad H, Francis D, do Carmo Franco M, Franco O, Frontera G, Fuchs F, Fuchs S, Fujita Y, Furusawa T, Gaciong Z, Gafencu M, Gareta D, Garnett S, Gaspoz J, Gasull M, Gates L, Geleijnse J, Ghasemian A, Giampaoli S, Gianfagna F, Giovannelli J, Giwercman A, Goldsmith R, Gross M, Rivas J, Gorbea M, Gottrand F, Graff-Iversen S, Grafnetter D, Grajda A, Grammatikopoulou M, Gregor R, Grodzicki T, Grøntved A, Gruden G, Grujic V, Gu D, Guan O, Gudnason V, Guerrero R, Guessous I, Guimaraes A, Gulliford M, Gunnlaugsdottir J, Gunter M, Guo X, Guo Y, Gupta P, Gureje O, Gurzkowska B, Gutierrez L, Gutzwiller F, Halkjær J, Hardy R, Kumar R, Hayes A, He J, Hendriks M, Cadena L, Heshmat R, Hihtaniemi I, Ho S, Ho S, Hobbs M, Hofman A, Hormiga C, Horta B, Houti L, Htay T, Htet A, Htike M, Hu Y, Hussieni A, Huu C, Huybrechts I, Hwalla N, Iacoviello L, Iannone A, Ibrahim M, Ikeda N, Ikram M, Irazola V, Islam M, Iwasaki M, Jackson R, Jacobs J, Jafar T, Jamil K, Jamrozik K, Jasienska G, Jiang C, Joffres M, Johansson M, Jonas J, Jørgensen T, Joshi P, Juolevi A, Jurak G, Jureša V, Kaaks R, Kafatos A, Kalter-Leibovici O, Kapantais E, Kasaeian A, Katz J, Kaur P, Kavousi M, Keil U, Boker L, Kelishadi R, Kemper H, Kengne A, Kersting M, Key T, Khader Y, Khalili D, Khang Y, Khaw K, Khouw I, Kiechl S, Killewo J, Kim J, Kiyohara Y, Klimont J, Kolle E, Kolsteren P, Korrovits P, Koskinen S, Kouda K, Koziel S, Kratzer W, Krokstad S, Kromhout D, Kruger H, Kula K, Kulaga Z, Kumar R, Kusuma Y, Kuulasmaa K, Kyobutungi C, Laamiri F, Laatikainen T, Lachat C, Laid Y, Lam T, Landrove O, Lanska V, Lappas G, Laugsand L, Laxmaiah A, Le Nguyen Bao K, Le T, Leclercq C, Lee J, Lee J, Lehtimäki T, Lekhraj R, León-Muñoz L, Li Y, Lim W, Lima-Costa M, Lin H, Lin X, Linneberg A, Lissner L, Litwin M, Liu J, Lorbeer R, Lotufo P, Lozano J, Luksiene D, Lundqvist A, Lunet N, Lytsy P, Ma G, Machi S, Maggi S, Magliano D, Makdisse M, Malekzadeh R, Malhotra R, Rao K, Manios Y, Mann J, Manzato E, Margozzini P, Markey O, Marques-Vidal P, Marrugat J, Martin-Prevel Y, Martorell R, Masoodi S, Matsha T, Mazur A, Mbanya J, McFarlane S, McGarvey S, McKee M, McLachlan S, McLean R, McNulty B, Yusof S, Mediene-Benchekor S, Meirhaeghe A, Meisinger C, Mendes L, Menezes A, Mensink G, Meshram I, Metspalu A, Mi J, Michaelsen K, Mikkel K, Miller J, Miquel J, Miranda J, Mišigoj-Duraković M, Mohamed M, Mohammad K, Mohammadifard N, Mohan V, Yusoff M, Molbo D, Møller N, Molnár D, Mondo C, Monterrubio E, Monyeki K, Moreira L, Morejon A, Moreno L, Morgan K, Mortensen E, Moschonis G, Mossakowska M, Mostafa A, Mota J, Motlagh M, Motta J, Mu T, Muiesan M, Müller-Nurasyid M, Murphy N, Mursu J, Murtagh E, Musa K, Musil V, Nagel G, Nakamura H, Námešná J, Nang E, Nangia V, Nankap M, Narake S, Navarrete-Muñoz E, Nenko I, Neovius M, Nervi F, Neuhauser H, Nguyen N, Nguyen Q, Nieto-Martínez R, Ning G, Ninomiya T, Nishtar S, Noale M, Norat T, Noto D, Al Nsour M, O’Reilly D, Ochoa-Avilés A, Oh K, Olayan I, Olinto M, Oltarzewski M, Omar M, Onat A, Ordunez P, Ortiz A, Osler M, Osmond C, Ostojic S, Otero J, Overvad K, Paccaud F, Padez C, Pajak A, Palli D, Palloni A, Palmieri L, Panda-Jonas S, Panza F, Parnell W, Parsaeian M, Pednekar M, Peeters P, Peixoto S, Pereira A, Pérez C, Peters A, Peykari N, Pham S, Pigeot I, Pikhart H, Pilav A, Pilotto L, Pistelli F, Pitakaka F, Piwonska A, Piwonski J, Plans-Rubió P, Poh B, Porta M, Portegies M, Poulimeneas D, Pradeepa R, Prashant M, Price J, Puiu M, Punab M, Qasrawi R, Qorbani M, Bao T, Radic I, Radisauskas R, Rahman M, Raitakari O, Raj M, Rao S, Ramachandran A, Ramke J, Ramos R, Rampal S, Rasmussen F, Redon J, Reganit P, Ribeiro R, Riboli E, Rigo F, de Wit T, Ritti-Dias R, Rivera J, Robinson S, Robitaille C, Rodríguez-Artalejo F, del Cristo Rodriguez-Perez M, Rodríguez-Villamizar L, Rojas-Martinez R, Rojroongwasinkul N, Romaguera D, Ronkainen K, Rosengren A, Rouse I, Rubinstein A, Rühli F, Rui O, Ruiz-Betancourt B, Horimoto A, Rutkowski M, Sabanayagam C, Sachdev H, Saidi O, Salanave B, Martinez E, Salomaa V, Salonen J, Salvetti M, Sánchez-Abanto J, Sandjaja, Sans S, Santos D, Santos O, dos Santos R, Santos R, Sardinha L, Sarrafzadegan N, Saum K, Savva S, Scazufca M, Rosario A, Schargrodsky H, Schienkiewitz A, Schmidt I, Schneider I, Schultsz C, Schutte A, Sein A, Sen A, Senbanjo I, Sepanlou S, Shalnova S, Shaw J, Shibuya K, Shin Y, Shiri R, Siantar R, Sibai A, Silva A, Silva D, Simon M, Simons J, Simons L, Sjostrom M, Slowikowska-Hilczer J, Slusarczyk P, Smeeth L, Smith M, Snijder M, So H, Sobngwi E, Soderberg S, Soekatri M, Solfrizzi V, Sonestedt E, Sørensen T, Sorić M, Jérome C, Soumare A, Staessen J, Starc G, Stathopoulou M, Staub K, Stavreski B, Steene-Johannessen J, Stehle P, Stein A, Stergiou G, Stessman J, Stieber J, Stöckl D, Stocks T, Stokwiszewski J, Stratton G, Strufaldi M, Sun C, Sundström J, Sung Y, Sunyer J, Suriyawongpaisal P, Swinburn B, Sy R, Szponar L, Tai E, Tammesoo M, Tamosiunas A, Tang L, Tang X, Tanser F, Tao Y, Tarawneh M, Tarp J, Tarqui-Mamani C, Taylor A, Tchibindat F, Thijs L, Thuesen B, Tjonneland A, Tolonen H, Tolstrup J, Topbas M, Topór-Madry R, Torrent M, Traissac P, Trichopoulou A, Trichopoulos D, Trinh O, Trivedi A, Tshepo L, Tulloch-Reid M, Tuomainen T, Tuomilehto J, Turley M, Tynelius P, Tzotzas T, Tzourio C, Ueda P, Ukoli F, Ulmer H, Unal B, Valdivia G, Vale S, Valvi D, van der Schouw Y, Van Herck K, Van Minh H, van Valkengoed I, Vanderschueren D, Vanuzzo D, Vatten L, Vega T, Velasquez-Melendez G, Veronesi G, Verschuren W, Viegi G, Viet L, Viikari-Juntura E, Vineis P, Vioque J, Virtanen J, Visvikis-Siest S, Viswanathan B, Vollenweider P, Voutilainen S, Vrijheid M, Wade A, Wagner A, Walton J, Mohamud W, Wang M, Wang Q, Wang Y, Wannamethee S, Wareham N, Weerasekera D, Whincup P, Widhalm K, Widyahening I, Wiecek A, Wilks R, Willeit J, Wojtyniak B, Wong J, Wong T, Woo J, Woodward M, Wu F, Wu J, Wu S, Xu H, Xu L, Yamborisut U, Yan W, Yang X, Yardim N, Ye X, Yiallouros P, Yoshihara A, You Q, Younger-Coleman N, Yusoff A, Zainuddin A, Zambon S, Zdrojewski T, Zeng Y, Zhao D, Zhao W, Zheng Y, Zhou M, Zhu D, Zimmermann E, Cisneros J. Trends in adult body-mass index in 200 countries from 1975 to 2014: a pooled analysis of 1698 population-based measurement studies with 19·2 million participants. The Lancet 2016, 387: 1377-1396. PMID: 27115820, PMCID: PMC7615134, DOI: 10.1016/s0140-6736(16)30054-x.Peer-Reviewed Original ResearchConceptsBody-mass indexMean body-mass indexHighest prevalence of underweightPrevalence of BMI categoriesBody-mass index categoryAdult body-mass indexPopulation-based data sourcesPrevalence of underweightAge-standardised prevalencePrevalence of obesityAdverse health outcomesPopulation-based studyGlobal obesity prevalenceObesity prevalenceBMI categoriesPrevalence of morbid obesityHealth outcomesMeasured heightUnderweightAdult participantsElevated riskMorbid obesityWorld's poorest regionsObesity targetsEstimate trends
2013
The State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors
Murray CJ, Atkinson C, Bhalla K, Birbeck G, Burstein R, Chou D, Dellavalle R, Danaei G, Ezzati M, Fahimi A, Flaxman D, Foreman, Gabriel S, Gakidou E, Kassebaum N, Khatibzadeh S, Lim S, Lipshultz SE, London S, Lopez, MacIntyre MF, Mokdad AH, Moran A, Moran AE, Mozaffarian D, Murphy T, Naghavi M, Pope C, Roberts T, Salomon J, Schwebel DC, Shahraz S, Sleet DA, Murray, Abraham J, Ali MK, Atkinson C, Bartels DH, Bhalla K, Birbeck G, Burstein R, Chen H, Criqui MH, Dahodwala, Jarlais, Ding EL, Dorsey ER, Ebel BE, Ezzati M, Fahami, Flaxman S, Flaxman AD, Gonzalez-Medina D, Grant B, Hagan H, Hoffman H, Kassebaum N, Khatibzadeh S, Leasher JL, Lin J, Lipshultz SE, Lozano R, Lu Y, Mallinger L, McDermott MM, Micha R, Miller TR, Mokdad AA, Mokdad AH, Mozaffarian D, Naghavi M, Narayan KM, Omer SB, Pelizzari PM, Phillips D, Ranganathan D, Rivara FP, Roberts T, Sampson U, Sanman E, Sapkota A, Schwebel DC, Sharaz S, Shivakoti R, Singh GM, Singh D, Tavakkoli M, Towbin JA, Wilkinson JD, Zabetian A, Murray, Abraham J, Ali MK, Alvardo M, Atkinson C, Baddour LM, Benjamin EJ, Bhalla K, Birbeck G, Bolliger I, Burstein R, Carnahan E, Chou D, Chugh SS, Cohen A, Colson KE, Cooper LT, Couser W, Criqui MH, Dabhadkar KC, Dellavalle RP, Jarlais, Dicker D, Dorsey ER, Duber H, Ebel BE, Engell RE, Ezzati M, Felson DT, Finucane MM, Flaxman S, Flaxman AD, Fleming T, Foreman, Forouzanfar MH, Freedman G, Freeman MK, Gakidou E, Gillum RF, Gonzalez-Medina D, Gosselin R, Gutierrez HR, Hagan H, Havmoeller R, Hoffman H, Jacobsen KH, James SL, Jasrasaria R, Jayarman S, Johns N, Kassebaum N, Khatibzadeh S, Lan Q, Leasher JL, Lim S, Lipshultz SE, London S, Lopez, Lozano R, Lu Y, Mallinger L, Meltzer M, Mensah GA, Michaud C, Miller TR, Mock C, Moffitt TE, Mokdad AA, Mokdad AH, Moran A, Naghavi M, Narayan KM, Nelson RG, Olives C, Omer SB, Ortblad K, Ostro B, Pelizzari PM, Phillips D, Raju M, Razavi H, Ritz B, Roberts T, Sacco RL, Salomon J, Sampson U, Schwebel DC, Shahraz S, Shibuya K, Silberberg D, Singh JA, Steenland K, Taylor JA, Thurston GD, Vavilala MS, Vos T, Wagner GR, Weinstock MA, Weisskopf MG, Wulf S, Murray. The State of US Health, 1990-2010: Burden of Diseases, Injuries, and Risk Factors. JAMA 2013, 310: 591-606. PMID: 23842577, PMCID: PMC5436627, DOI: 10.1001/jama.2013.13805.Peer-Reviewed Original ResearchConceptsAge-standardized YLL rateHealthy life expectancyBurden of diseaseRisk factorsLife expectancyPopulation healthYLL ratesAge-standardized YLD rateChronic obstructive pulmonary diseaseHigher body mass indexAge-standardized death ratesDeath rateReference life expectancyRisk-outcome pairsSum of YLDsChronic kidney diseaseObstructive pulmonary diseaseHigh blood pressureIschemic heart diseaseBody mass indexLow back painDrug use disordersDisease 2010 studyMajor depressive disorderMajor health problem
2012
A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010
Lim SS, Vos T, Flaxman AD, Danaei G, Shibuya K, Adair-Rohani H, AlMazroa M, Amann M, Anderson H, Andrews K, Aryee M, Atkinson C, Bacchus L, Bahalim A, Balakrishnan K, Balmes J, Barker-Collo S, Baxter A, Bell M, Blore J, Blyth F, Bonner C, Borges G, Bourne R, Boussinesq M, Brauer M, Brooks P, Bruce N, Brunekreef B, Bryan-Hancock C, Bucello C, Buchbinder R, Bull F, Burnett R, Byers T, Calabria B, Carapetis J, Carnahan E, Chafe Z, Charlson F, Chen H, Chen J, Cheng A, Child J, Cohen A, Colson K, Cowie B, Darby S, Darling S, Davis A, Degenhardt L, Dentener F, Jarlais D, Devries K, Dherani M, Ding E, Dorsey E, Driscoll T, Edmond K, Ali S, Engell R, Erwin P, Fahimi S, Falder G, Farzadfar F, Ferrari A, Finucane M, Flaxman S, Fowkes F, Freedman G, Freeman M, Gakidou E, Ghosh S, Giovannucci E, Gmel G, Graham K, Grainger R, Grant B, Gunnell D, Gutierrez H, Hall W, Hoek H, Hogan A, Hosgood H, Hoy D, Hu H, Hubbell B, Hutchings S, Ibeanusi S, Jacklyn G, Jasrasaria R, Jonas J, Kan H, Kanis J, Kassebaum N, Kawakami N, Khang Y, Khatibzadeh S, Khoo J, Kok C, Laden F, Lalloo R, Lan Q, Lathlean T, Leasher J, Leigh J, Li Y, Lin J, Lipshultz S, London S, Lozano R, Lu Y, Mak J, Malekzadeh R, Mallinger L, Marcenes W, March L, Marks R, Martin R, McGale P, McGrath J, Mehta S, Memish Z, Mensah G, Merriman T, Micha R, Michaud C, Mishra V, Hanafiah K, Mokdad A, Morawska L, Mozaffarian D, Murphy T, Naghavi M, Neal B, Nelson P, Nolla J, Norman R, Olives C, Omer S, Orchard J, Osborne R, Ostro B, Page A, Pandey K, Parry C, Passmore E, Patra J, Pearce N, Pelizzari P, Petzold M, Phillips M, Pope D, Pope C, Powles J, Rao M, Razavi H, Rehfuess E, Rehm J, Ritz B, Rivara F, Roberts T, Robinson C, Rodriguez-Portales J, Romieu I, Room R, Rosenfeld L, Roy A, Rushton L, Salomon J, Sampson U, Sanchez-Riera L, Sanman E, Sapkota A, Seedat S, Shi P, Shield K, Shivakoti R, Singh G, Sleet D, Smith E, Smith K, Stapelberg N, Steenland K, Stöckl H, Stovner L, Straif K, Straney L, Thurston G, Tran J, Van Dingenen R, van Donkelaar A, Veerman J, Vijayakumar L, Weintraub R, Weissman M, White R, Whiteford H, Wiersma S, Wilkinson J, Williams H, Williams W, Wilson N, Woolf A, Yip P, Zielinski J, Lopez A, Murray C, Ezzati M. A comparative risk assessment of burden of disease and injury attributable to 67 risk factors and risk factor clusters in 21 regions, 1990–2010: a systematic analysis for the Global Burden of Disease Study 2010. The Lancet 2012, 380: 2224-2260. PMID: 23245609, PMCID: PMC4156511, DOI: 10.1016/s0140-6736(12)61766-8.Peer-Reviewed Original ResearchConceptsSecond-hand smokeDisease Study 2010High blood pressureRisk factorsDisease burdenGlobal disease burdenTobacco smokingRisk factor exposureBlood pressureGlobal DALYsChildhood underweightRelative riskGlobal burdenStudy 2010Unimproved waterCommunicable diseasesHigher body mass indexHigh-income North AmericaAlcohol useChildhood communicable diseasesDisability-adjusted life yearsRisk factor clustersDietary risk factorsCause-specific deathBody mass index