2024
Use of electronic health records to characterize patients with uncontrolled hypertension in two large health system networks
Lu Y, Keeley E, Barrette E, Cooper-DeHoff R, Dhruva S, Gaffney J, Gamble G, Handke B, Huang C, Krumholz H, McDonough C, Schulz W, Shaw K, Smith M, Woodard J, Young P, Ervin K, Ross J. Use of electronic health records to characterize patients with uncontrolled hypertension in two large health system networks. BMC Cardiovascular Disorders 2024, 24: 497. PMID: 39289597, PMCID: PMC11409735, DOI: 10.1186/s12872-024-04161-x.Peer-Reviewed Original ResearchConceptsElectronic health recordsHealth recordsHealth systemUncontrolled hypertensionUse of electronic health recordsHypertension managementElectronic health record systemsOneFlorida Clinical Research ConsortiumElectronic health record dataYale New Haven Health SystemBP measurementsICD-10-CM codesHealth system networkPublic health priorityICD-10-CMIncidence rate of deathElevated BP measurementsElevated blood pressure measurementsHealthcare visitsAmbulatory careHealth priorityRetrospective cohort studyEHR dataOneFloridaBlood pressure measurementsHypertension Trends and Disparities Over 12 Years in a Large Health System: Leveraging the Electronic Health Records
Brush J, Lu Y, Liu Y, Asher J, Li S, Sawano M, Young P, Schulz W, Anderson M, Burrows J, Krumholz H. Hypertension Trends and Disparities Over 12 Years in a Large Health System: Leveraging the Electronic Health Records. Journal Of The American Heart Association 2024, 13: e033253. PMID: 38686864, PMCID: PMC11179912, DOI: 10.1161/jaha.123.033253.Peer-Reviewed Original ResearchConceptsElectronic health recordsRegional health systemImprove hypertension careHealth systemHealth recordsHypertension careDiastolic blood pressureAge-adjusted prevalence ratesNon-Hispanic Black patientsPrevalence ratesLarger health systemCross-sectional analysisTransformation of medical dataLeveraging real-world dataHigh prevalence rateHypertension trendsHypertension prevalenceBlood pressureBlood pressure measurementsHypertension diagnosisPrimary outcomeNational trendsProportion of patientsAntihypertensive medicationsBlack patientsDigital Health Interventions for Hypertension Management in US Populations Experiencing Health Disparities
Katz M, Mszar R, Grimshaw A, Gunderson C, Onuma O, Lu Y, Spatz E. Digital Health Interventions for Hypertension Management in US Populations Experiencing Health Disparities. JAMA Network Open 2024, 7: e2356070. PMID: 38353950, PMCID: PMC10867699, DOI: 10.1001/jamanetworkopen.2023.56070.Peer-Reviewed Original ResearchConceptsDigital health interventionsHealth disparitiesHealth interventionsSystematic reviewSystolic BPSocial determinants of healthHypertension managementCommunity health workersFactors associated with cardiovascular diseaseDeterminants of healthLeveraging digital healthRemote BP monitoringDigital health technologiesStandard care groupMeta-analysisBlood pressureDiastolic BPPreferred Reporting ItemsControl groupSystolic BP changeBaseline to 6Random-effects modelSkilled nursingCultural tailoringSocial determinants
2023
Quantifying Blood Pressure Visit-to-Visit Variability in the Real-World Setting: A Retrospective Cohort Study
Lu Y, Linderman G, Mahajan S, Liu Y, Huang C, Khera R, Mortazavi B, Spatz E, Krumholz H. Quantifying Blood Pressure Visit-to-Visit Variability in the Real-World Setting: A Retrospective Cohort Study. Circulation Cardiovascular Quality And Outcomes 2023, 16: e009258. PMID: 36883456, DOI: 10.1161/circoutcomes.122.009258.Peer-Reviewed Original ResearchConceptsRetrospective cohort studyBlood pressure valuesPatient characteristicsReal-world settingCohort studyPatient subgroupsYale New Haven Health SystemMean body mass indexSystolic blood pressure valuesBlood pressure visitHistory of hypertensionCoronary artery diseaseManagement of patientsMultivariable linear regression modelsBlood pressure readingsBody mass indexPatient-level measuresBlood pressure variationAbsolute standardized differencesNon-Hispanic whitesAntihypertensive medicationsReal-world practiceVisit variabilityArtery diseaseRegression modelsDeveloping an Actionable Taxonomy of Persistent Hypertension Using Electronic Health Records
Lu Y, Du C, Khidir H, Caraballo C, Mahajan S, Spatz E, Curry L, Krumholz H. Developing an Actionable Taxonomy of Persistent Hypertension Using Electronic Health Records. Circulation Cardiovascular Quality And Outcomes 2023, 16: e009453. PMID: 36727515, DOI: 10.1161/circoutcomes.122.009453.Peer-Reviewed Original ResearchMeSH KeywordsAgedAntihypertensive AgentsBlood PressureElectronic Health RecordsFemaleHumansHypertensionMaleMiddle AgedConceptsPersistent hypertensionElectronic health recordsBlood pressureHealth recordsPharmacologic agentsPrescribed treatmentYale New Haven Health SystemTreatment planAdditional pharmacologic agentsAntihypertensive treatment intensificationConsecutive outpatient visitsElevated blood pressurePersistence of hypertensionElectronic health record dataHealth record dataEligible patientsTreatment intensificationChart reviewHispanic patientsOutpatient visitsMean agePharmacological treatmentConventional content analysisHypertensionClinician notes
2022
Revisiting ACCORD: Should Blood Pressure Targets in People With and Without Type 2 Diabetes Be Different?
Du CX, Huang C, Lu Y, Spatz ES, Lipska KJ, Krumholz HM. Revisiting ACCORD: Should Blood Pressure Targets in People With and Without Type 2 Diabetes Be Different? The American Journal Of Medicine 2022, 136: 6-8. PMID: 35981647, DOI: 10.1016/j.amjmed.2022.07.023.Peer-Reviewed Original ResearchHemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography
Caraballo C, Mahajan S, Gu J, Lu Y, Spatz ES, Dreyer RP, Zhang M, Sun N, Ren Y, Zheng X, Zhao H, Lu H, J. Z, Krumholz HM. Hemodynamic differences between women and men with elevated blood pressure in China: A non-invasive assessment of 45,082 adults using impedance cardiography. PLOS ONE 2022, 17: e0269777. PMID: 35700163, PMCID: PMC9197037, DOI: 10.1371/journal.pone.0269777.Peer-Reviewed Original ResearchConceptsElevated blood pressureSystemic vascular resistance indexVascular resistance indexBlood pressureCardiac indexResistance indexHigh systemic vascular resistance indexLower systemic vascular resistance indexHigher mean systolic blood pressureMean diastolic blood pressureMean systolic blood pressureImpedance cardiographyLow cardiac indexHigher cardiac indexDiastolic blood pressureSystolic blood pressureBody mass indexYear old womanPersonalization of treatmentSame age groupNon-invasive assessmentSex differencesHemodynamic profileMass indexHemodynamic differences
2021
Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial
Wang L, Lu Y, Wang H, Gu J, J Z, Lian Z, Zhang Z, Krumholz H, Sun N. Effectiveness of an impedance cardiography guided treatment strategy to improve blood pressure control in a real-world setting: results from a pragmatic clinical trial. Open Heart 2021, 8: e001719. PMID: 34580169, PMCID: PMC8477318, DOI: 10.1136/openhrt-2021-001719.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overAntihypertensive AgentsBlood PressureCardiography, ImpedanceChinaClinical Decision-MakingFemaleFollow-Up StudiesHumansHypertensionIncidenceMaleMiddle AgedPractice Guidelines as TopicRetrospective StudiesTherapy, Computer-AssistedTime FactorsTreatment OutcomeYoung AdultConceptsBody mass indexPeking University People's HospitalStandard care groupBlood pressure controlSystolic BPHaemodynamic groupsTreatment strategiesImpedance cardiographyBaseline BPBP goalHypertension clinicHaemodynamic profileBP levelsCare groupPeople's HospitalMean baseline systolic BPPressure controlReal-world clinical practiceBaseline systolic BPMean systolic BPDiastolic BP levelsProportion of patientsPragmatic clinical trialsReal-world populationBaseline DBP
2016
Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants
Zhou B, Bentham J, Di Cesare M, Bixby H, Danaei G, Cowan M, Paciorek C, Singh G, Hajifathalian K, Bennett J, Taddei C, Bilano V, Carrillo-Larco R, Djalalinia S, Khatibzadeh S, Lugero C, Peykari N, Zhang W, Lu Y, Stevens G, Riley L, Bovet P, Elliott P, Gu D, Ikeda N, Jackson R, Joffres M, Kengne A, Laatikainen T, Lam T, Laxmaiah A, Liu J, Miranda J, Mondo C, Neuhauser H, Sundström J, Smeeth L, Soric M, Woodward M, Ezzati M, Abarca-Gómez L, Abdeen Z, Rahim H, Abu-Rmeileh N, Acosta-Cazares B, Adams R, Aekplakorn W, Afsana K, Aguilar-Salinas C, Agyemang C, Ahmadvand A, Ahrens W, Al Raddadi R, Al Woyatan R, Ali M, Alkerwi A, Aly E, Amouyel P, Amuzu A, Andersen L, Anderssen S, Ängquist L, Anjana R, Ansong D, Aounallah-Skhiri H, Araújo J, Ariansen I, Aris T, Arlappa N, Aryal K, Arveiler D, Assah F, Assunção M, Avdicová M, Azevedo A, Azizi F, Babu B, Bahijri S, Balakrishna N, Bandosz P, Banegas J, Barbagallo C, Barceló A, Barkat A, Barros A, Barros M, Bata I, Batieha A, Baur L, Beaglehole R, Romdhane H, Benet M, Benson L, Bernabe-Ortiz A, Bernotiene G, Bettiol H, Bhagyalaxmi A, Bharadwaj S, Bhargava S, Bi Y, Bikbov M, Bjerregaard P, Bjertness E, Björkelund C, Blokstra A, Bo S, Bobak M, Boeing H, Boggia J, Boissonnet C, Bongard V, Braeckman L, Brajkovich I, Branca F, Breckenkamp J, Brenner H, Brewster L, Bruno G, Bueno-de-Mesquita H, Bugge A, Burns C, Bursztyn M, de León A, Cacciottolo J, Cameron C, Can G, Cândido A, Capuano V, Cardoso V, Carlsson A, Carvalho M, Casanueva F, Casas J, Caserta C, Chamukuttan S, Chan A, Chan Q, Chaturvedi H, Chaturvedi N, Chen C, Chen F, Chen H, Chen S, Chen Z, Cheng C, Dekkaki I, Chetrit A, Chiolero A, Chiou S, Chirita-Emandi A, Cho B, Cho Y, Chudek J, Cifkova R, Claessens F, Clays E, Concin H, Cooper C, Cooper R, Coppinger T, Costanzo S, Cottel D, Cowell C, Craig C, Crujeiras A, Cruz J, D'Arrigo G, d'Orsi E, Dallongeville J, Damasceno A, Dankner R, Dantoft T, Dauchet L, De Backer G, De Bacquer D, de Gaetano G, De Henauw S, De Smedt D, Deepa M, Dehghan A, Delisle H, Deschamps V, Dhana K, Di Castelnuovo A, Dias-da-Costa J, Diaz A, Dickerson T, Do H, Dobson A, Donfrancesco C, Donoso S, Döring A, Doua K, Drygas W, Dulskiene V, Džakula A, Dzerve V, Dziankowska-Zaborszczyk E, Eggertsen R, Ekelund U, El Ati J, Ellert U, Elliott P, Elosua R, Erasmus R, Erem C, Eriksen L, de la Peña J, Evans A, Faeh D, Fall C, Farzadfar F, Felix-Redondo F, Ferguson T, Fernández-Bergés D, Ferrante D, Ferrari M, Ferreccio C, Ferrieres J, Finn J, Fischer K, Föger B, Foo L, Forslund A, Forsner M, Fortmann S, Fouad H, Francis D, Franco M, Franco O, Frontera G, Fuchs F, Fuchs S, Fujita Y, Furusawa T, Gaciong Z, Gareta D, Garnett S, Gaspoz J, Gasull M, Gates L, Gavrila D, Geleijnse J, Ghasemian A, Ghimire A, Giampaoli S, Gianfagna F, Giovannelli J, Goldsmith R, Gonçalves H, Gross M, Rivas J, Gottrand F, Graff-Iversen S, Grafnetter D, Grajda A, Gregor R, Grodzicki T, Grøntved A, Gruden G, Grujic V, Gu D, Guan O, Gudnason V, Guerrero R, Guessous I, Guimaraes A, Gulliford M, Gunnlaugsdottir J, Gunter M, Gupta P, Gureje O, Gurzkowska B, Gutierrez L, Gutzwiller F, Hadaegh F, Halkjær J, Hambleton I, Hardy R, Harikumar R, Hata J, Hayes A, He J, Hendriks M, Henriques A, Cadena L, Herrala S, Heshmat R, Hihtaniemi I, Ho S, Ho S, Hobbs M, Hofman A, Dinc G, Hormiga C, Horta B, Houti L, Howitt C, Htay T, Htet A, Hu Y, Huerta J, Husseini A, Huybrechts I, Hwalla N, Iacoviello L, Iannone A, Ibrahim M, Ikram M, Irazola V, Islam M, Ivkovic V, Iwasaki M, Jackson R, Jacobs J, Jafar T, Jamrozik K, Janszky I, Jasienska G, Jelakovic B, Jiang C, Joffres M, Johansson M, Jonas J, Jørgensen T, Joshi P, Juolevi A, Jurak G, Jureša V, Kaaks R, Kafatos A, Kalter-Leibovici O, Kamaruddin N, Kasaeian A, Katz J, Kauhanen J, Kaur P, Kavousi M, Kazakbaeva G, Keil U, Boker L, Keinänen-Kiukaanniemi S, Kelishadi R, Kemper H, Kengne A, Kersting M, Key T, Khader Y, Khalili D, Khang Y, Khaw K, Kiechl S, Killewo J, Kim J, Klumbiene J, Kolle E, Kolsteren P, Korrovits P, Koskinen S, Kouda K, Koziel S, Kristensen P, Krokstad S, Kromhout D, Kruger H, Kubinova R, Kuciene R, Kuh D, Kujala U, Kula K, Kulaga Z, Kumar R, Kurjata P, Kusuma Y, Kuulasmaa K, Kyobutungi C, Laatikainen T, Lachat C, Lam T, Landrove O, Lanska V, Lappas G, Larijani B, Laugsand L, Laxmaiah A, Bao K, Le T, Leclercq C, Lee J, Lee J, Lehtimäki T, Lekhraj R, León-Muñoz L, Levitt N, Li Y, Lilly C, Lim W, Lima-Costa M, Lin H, Lin X, Linneberg A, Lissner L, Litwin M, Lorbeer R, Lotufo P, Lozano J, Luksiene D, Lundqvist A, Lunet N, Lytsy P, Ma G, Ma J, Machado-Coelho G, Machi S, Maggi S, Magliano D, Majer M, Makdisse M, Malekzadeh R, Malhotra R, Rao K, Malyutina S, Manios Y, Mann J, Manzato E, Margozzini P, Marques-Vidal P, Marrugat J, Martorell R, Mathiesen E, Matijasevich A, Matsha T, Mbanya J, Posso A, McFarlane S, McGarvey S, McLachlan S, McLean R, McNulty B, Khir A, Mediene-Benchekor S, Medzioniene J, Meirhaeghe A, Meisinger C, Menezes A, Menon G, Meshram I, Metspalu A, Mi J, Mikkel K, Miller J, Miquel J, Mišigoj-Durakovic M, Mohamed M, Mohammad K, Mohammadifard N, Mohan V, Yusoff M, Møller N, Molnár D, Momenan A, Mondo C, Monyeki K, Moreira L, Morejon A, Moreno L, Morgan K, Moschonis G, Mossakowska M, Mostafa A, Mota J, Motlagh M, Motta J, Muiesan M, Müller-Nurasyid M, Murphy N, Mursu J, Musil V, Nagel G, Naidu B, Nakamura H, Námešná J, Nang E, Nangia V, Narake S, Navarrete-Muñoz E, Ndiaye N, Neal W, Nenko I, Nervi F, Nguyen N, Nguyen Q, Nieto-Martínez R, Niiranen T, Ning G, Ninomiya T, Nishtar S, Noale M, Noboa O, Noorbala A, Noorbala T, Noto D, Al Nsour M, O'Reilly D, Oh K, Olinto M, Oliveira I, Omar M, Onat A, Ordunez P, Osmond C, Ostojic S, Otero J, Overvad K, Owusu-Dabo E, Paccaud F, Padez C, Pahomova E, Pajak A, Palli D, Palmieri L, Panda-Jonas S, Panza F, Papandreou D, Parnell W, Parsaeian M, Pecin I, Pednekar M, Peer N, Peeters P, Peixoto S, Pelletier C, Peltonen M, Pereira A, Pérez R, Peters A, Petkeviciene J, Pham S, Pigeot I, Pikhart H, Pilav A, Pilotto L, Pitakaka F, Plans-Rubió P, Polakowska M, Polašek O, Porta M, Portegies M, Pourshams A, Pradeepa R, Prashant M, Price J, Puiu M, Punab M, Qasrawi R, Qorbani M, Radic I, Radisauskas R, Rahman M, Raitakari O, Raj M, Rao S, Ramachandran A, Ramos E, Rampal S, Reina D, Rasmussen F, Redon J, Reganit P, Ribeiro R, Riboli E, Rigo F, de Wit T, Ritti-Dias R, Robinson S, Robitaille C, Rodríguez-Artalejo F, Rodriguez-Perez del Cristo M, Rodríguez-Villamizar L, Rojas-Martinez R, Rosengren A, Rubinstein A, Rui O, Ruiz-Betancourt B, Horimoto A, Rutkowski M, Sabanayagam C, Sachdev H, Saidi O, Sakarya S, Salanave B, Salazar Martinez E, Salmerón D, Salomaa V, Salonen J, Salvetti M, Sánchez-Abanto J, Sans S, Santos D, Santos I, dos Santos R, Santos R, Saramies J, Sardinha L, Margolis G, Sarrafzadegan N, Saum K, Savva S, Scazufca M, Schargrodsky H, Schneider I, Schultsz C, Schutte A, Sen A, Senbanjo I, Sepanlou S, Sharma S, Shaw J, Shibuya K, Shin D, Shin Y, Siantar R, Sibai A, Silva D, Simon M, Simons J, Simons L, Sjöström M, Skovbjerg S, Slowikowska-Hilczer J, Slusarczyk P, Smeeth L, Smith M, Snijder M, So H, Sobngwi E, Söderberg S, Solfrizzi V, Sonestedt E, Song Y, Sørensen T, Jérome C, Soumare A, Staessen J, Starc G, Stathopoulou M, Stavreski B, Steene-Johannessen J, Stehle P, Stein A, Stergiou G, Stessman J, Stieber J, Stöckl D, Stocks T, Stokwiszewski J, Stronks K, Strufaldi M, Sun C, Sundström J, Sung Y, Suriyawongpaisal P, Sy R, Tai E, Tammesoo M, Tamosiunas A, Tang L, Tang X, Tanser F, Tao Y, Tarawneh M, Tarqui-Mamani C, Taylor A, Theobald H, Thijs L, Thuesen B, Tjonneland A, Tolonen H, Tolstrup J, Topbas M, Topór-Madry R, Tormo M, Torrent M, Traissac P, Trichopoulos D, Trichopoulou A, Trinh O, Trivedi A, Tshepo L, Tulloch-Reid M, Tuomainen T, Tuomilehto J, Turley M, Tynelius P, Tzourio C, Ueda P, Ugel E, Ulmer H, Uusitalo H, Valdivia G, Valvi D, van der Schouw Y, Van Herck K, van Rossem L, van Valkengoed I, Vanderschueren D, Vanuzzo D, Vatten L, Vega T, Velasquez-Melendez G, Veronesi G, Verschuren W, Verstraeten R, Victora C, Viet L, Viikari-Juntura E, Vineis P, Vioque J, Virtanen J, Visvikis-Siest S, Viswanathan B, Vollenweider P, Voutilainen S, Vrdoljak A, Vrijheid M, Wade A, Wagner A, Walton J, Mohamud W, Wang M, Wang Q, Wang Y, Wannamethee S, Wareham N, Wedderkopp N, Weerasekera D, Whincup P, Widhalm K, Widyahening I, Wiecek A, Wijga A, Wilks R, Willeit J, Willeit P, Williams E, Wilsgaard T, Wojtyniak B, Wong T, Wong-McClure R, Woo J, Woodward M, Wu A, Wu F, Wu S, Xu H, Yan W, Yang X, Ye X, Yiallouros P, Yoshihara A, Younger-Coleman N, Yusoff A, Yusoff M, Zambon S, Zdrojewski T, Zeng Y, Zhao D, Zhao W, Zheng Y, Zhu D, Zimmermann E, Zuñiga Cisneros J. Worldwide trends in blood pressure from 1975 to 2015: a pooled analysis of 1479 population-based measurement studies with 19·1 million participants. The Lancet 2016, 389: 37-55. PMID: 27863813, PMCID: PMC5220163, DOI: 10.1016/s0140-6736(16)31919-5.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureBlood pressure levelsSystolic blood pressureBlood pressureMean systolicMiddle-income countriesGlobal age-standardised prevalenceMean diastolic blood pressureMean systolic blood pressureHigher blood pressure levelsNumber of adultsAge-standardised prevalenceChronic kidney diseaseMean blood pressurePopulation-based studyAge-specific prevalenceImportant risk factorSaharan AfricaKidney diseasePooled analysisRisk factorsCardiovascular diseaseHigh-income countriesPrevalencePressure levels
2013
Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants
Lu Y, Hajifathalian K, Ezzati M, Woodward M, Rimm E, Danaei G. Metabolic mediators of the effects of body-mass index, overweight, and obesity on coronary heart disease and stroke: a pooled analysis of 97 prospective cohorts with 1·8 million participants. The Lancet 2013, 383: 970-983. PMID: 24269108, PMCID: PMC3959199, DOI: 10.1016/s0140-6736(13)61836-x.Peer-Reviewed Original ResearchMeSH KeywordsBiomarkersBlood GlucoseBlood PressureBody Mass IndexCholesterolCoronary DiseaseHumansObesityOverweightRisk FactorsStrokeConceptsBody mass indexCoronary heart diseaseHigher body mass indexHazard ratioBlood pressureExcess riskHeart diseaseEffect of BMIImperial College Healthcare NHS TrustMetabolic risk factorsProspective cohort studyAverage blood pressureHigh blood pressureCardiovascular disease preventionUK Medical Research CouncilNational InstituteRandom-effects modelMedical Research CouncilBiomedical Research CentreCohort studyProspective cohortStroke eventsNormal weightPooled analysisUS National Institutes