Metabolic products of [2‐13C]ethanol in the rat brain after chronic ethanol exposure
Wang J, Du H, Ma X, Pittman B, Castracane L, Li T, Behar KL, Mason GF. Metabolic products of [2‐13C]ethanol in the rat brain after chronic ethanol exposure. Journal Of Neurochemistry 2013, 127: 353-364. PMID: 24033360, PMCID: PMC6145094, DOI: 10.1111/jnc.12405.Peer-Reviewed Original ResearchConceptsChronic ethanol exposureEthanol exposureCerebral oxidationAdult male Sprague-Dawley ratsMale Sprague-Dawley ratsEthanol-derived acetateEthanol-exposed ratsSprague-Dawley ratsBrain energy metabolismLateral tail veinEthanol-naïve ratsLong-term adaptationCerebral uptakeIntravenous infusionControl ratsRat brainTail veinChronic exposureRatsRoom airIngested ethanolGABABrainKey neurochemicalsEnergy metabolismOxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure
Wang J, Du H, Jiang L, Ma X, de Graaf RA, Behar KL, Mason GF. Oxidation of ethanol in the rat brain and effects associated with chronic ethanol exposure. Proceedings Of The National Academy Of Sciences Of The United States Of America 2013, 110: 14444-14449. PMID: 23940368, PMCID: PMC3761635, DOI: 10.1073/pnas.1306011110.Peer-Reviewed Original ResearchConceptsChronic ethanol exposureEthanol-naïve ratsAlcohol exposureEthanol exposureAdult male Sprague-Dawley ratsMale Sprague-Dawley ratsMin/Chronic alcohol exposureCerebral glucose metabolismAcute alcohol exposureEthanol-treated ratsSprague-Dawley ratsCortical astrogliaOverall oxidative metabolismRat brainGlucose metabolismRatsRoom airLiving brainAstrogliaSubcortical tissueOxidative metabolismNeuronsBrainOxidative damage