Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects
Chowdhury GM, Zhang J, Thomas M, Banasr M, Ma X, Pittman B, Bristow L, Schaeffer E, Duman RS, Rothman DL, Behar KL, Sanacora G. Transiently increased glutamate cycling in rat PFC is associated with rapid onset of antidepressant-like effects. Molecular Psychiatry 2016, 22: 120-126. PMID: 27067013, PMCID: PMC5345902, DOI: 10.1038/mp.2016.34.Peer-Reviewed Original ResearchConceptsAntidepressant-like efficacyAntidepressant actionRo 25Glutamate cyclingAntidepressant-like effectsRapid antidepressant effectsClear dose-dependent effectRapid antidepressant actionsDose-dependent effectEffects of scopolamineRapid transient riseAntidepressant effectsAntidepressant propertiesIntravenous infusionSingle doseAntidepressant activityIntraperitoneal injectionClinical trialsDrug injectionAwake ratsNovel agentsRat PFCRodent modelsRapid onsetUnique drug