Featured Publications
Influence of Nonsyndromic Bicoronal Synostosis and Syndromic Influences on Orbit and Periorbital Malformation
Lu X, Forte AJ, Dinis J, Junn A, Alperovich M, Alonso N, Persing JA. Influence of Nonsyndromic Bicoronal Synostosis and Syndromic Influences on Orbit and Periorbital Malformation. Plastic & Reconstructive Surgery 2022, 149: 930e-942e. PMID: 35286288, DOI: 10.1097/prs.0000000000009051.Peer-Reviewed Original ResearchConceptsApert syndromeCrouzon syndromeBicoronal synostosisNonsyndromic bicoronal synostosisNonsyndromic casesPreoperative computed tomography scansSpine positionCLINICAL QUESTION/LEVELComputed tomography scanOrbital cavity volumeLateral orbital wallTomography scanApert patientsMaxillary retrusionPremature suture fusionMaxillary hypoplasiaSyndromePatientsCrouzon patientsOrbital wallSyndromic craniosynostosisAnteroposterior lengthVolumetric analysisSynostosisMalformationsOrbital and Periorbital Dysmorphology in Untreated Pfeiffer Syndrome
Lu X, Forte AJ, Allam O, Park KE, Wilson A, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Orbital and Periorbital Dysmorphology in Untreated Pfeiffer Syndrome. Plastic & Reconstructive Surgery 2022, 149: 731e-742e. PMID: 35171849, DOI: 10.1097/prs.0000000000008928.Peer-Reviewed Original ResearchConceptsPfeiffer syndrome patientsMonths of ageOrbital cavity volumeSyndrome patientsPfeiffer patientsSphenoid boneGlobe volumeAnterior positioningCLINICAL QUESTION/LEVELNormal control subjectsYears of ageSoft tissue volumeControl subjectsSignificant hypoplasiaPatientsBone volumePfeiffer syndromeVisual impairmentBony orbitAnteroposterior lengthMaxillaVolumetric analysisAgeMonthsMaterialise softwareVirtual Coordinate System in Unicoronal Synostosis
Lu X, Forte A, Persing JA. Virtual Coordinate System in Unicoronal Synostosis. Plastic & Reconstructive Surgery Global Open 2021, 9: e3616. PMID: 34422508, PMCID: PMC8376362, DOI: 10.1097/gox.0000000000003616.Peer-Reviewed Original ResearchUnicoronal synostosisMid-sagittal planeSkull baseSynostotic sideAnterior skull baseNonsyndromic unicoronal synostosisPosterior skull baseContralateral sideCT scanProtrusive pointCoronal planeFrankfort horizontal planeSynostosisSupraorbital rimFrontal boneFrontozygomatic sutureSagittal planeFused suturesPatientsSutureOrbitofacial morphology changes with different suture synostoses in Crouzon syndrome
Lu X, Forte AJ, Junn A, Dinis J, Alperovich M, Alonso N, Persing JA. Orbitofacial morphology changes with different suture synostoses in Crouzon syndrome. Journal Of Cranio-Maxillofacial Surgery 2021, 50: 406-418. PMID: 35065874, DOI: 10.1016/j.jcms.2021.06.012.Peer-Reviewed Original ResearchConceptsCrouzon syndrome patientsSquamosal synostosisSyndrome patientsCT scanBicoronal synostosisCrouzon syndromeComputed tomography scanSoft tissue volumeType ISurgical interventionTomography scanNormal controlsOccipital expansionGlobe volumeCrouzon patientsSagittal synostosisPatientsAnteroposterior lengthSynostosisOrbital rimStatistical significanceTissue volumeSynostosesType IVType VAirway Growth in Preoperative Patients with Crouzon Syndrome
Lu X, Forte AJ, Park KE, Allam O, Smetona J, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Airway Growth in Preoperative Patients with Crouzon Syndrome. Facial Plastic Surgery & Aesthetic Medicine 2021, 23: 191-197. PMID: 33577380, DOI: 10.1089/fpsam.2020.0441.Peer-Reviewed Original ResearchConceptsYears of ageNasal airway volumeAirway volumeCrouzon syndromePharyngeal airwayCross-sectional areaAirway cross-sectional areaObstructive sleep apneaMonths of agePreoperative patientsSleep apneaMaximal constrictionAirway developmentAirway growthTomography scanAge subgroupsCT scanPatientsSyndromeCrouzon patientsNatural historyAgeNormal dimensionsAirwayMaterialise softwareGrowth patterns of the airway in Crouzon syndrome patients with different types of cranial vault suture synostosis
Lu X, Forte AJ, Wilson A, Park KE, Allam O, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Growth patterns of the airway in Crouzon syndrome patients with different types of cranial vault suture synostosis. International Journal Of Oral And Maxillofacial Surgery 2020, 50: 924-932. PMID: 33384236, DOI: 10.1016/j.ijom.2020.11.023.Peer-Reviewed Original ResearchConceptsAirway volumeCrouzon syndrome patientsYears of ageNasal airwaySyndrome patientsCrouzon patientsPharyngeal airwayCrouzon syndromeSuture synostosisNasopharyngeal airway volumePharyngeal airway volumeNasal airway volumeType IComputed tomography scanType IIIBilateral coronal synostosisAirway compromiseRespiratory difficultyControl subjectsTomography scanAirwayPatientsPharyngeal volumeSagittal synostosisCoronal synostosisNasopharyngeal airway and subcranial space analysis in Pfeiffer syndrome
Lu X, Forte A, Allam O, Park K, Junn A, Alperovich M, Steinbacher D, Tonello C, Alonso N, Persing J. Nasopharyngeal airway and subcranial space analysis in Pfeiffer syndrome. British Journal Of Oral And Maxillofacial Surgery 2020, 59: 592-598. PMID: 33863588, DOI: 10.1016/j.bjoms.2020.10.008.Peer-Reviewed Original ResearchConceptsAirway volumeNasal airwayPfeiffer syndromeNasopharyngeal airwayPharyngeal airwayComputed tomogramsCross-sectional areaPharyngeal airway volumeNasal airway volumePreoperative computed tomogramsMaxillomandibular advancementRespiratory crisisSurgical treatmentUpper airwayChoanal stenosisAirwayPatientsNasal pathwayMaxillary expansionRegional abnormalitiesSyndromeAnteroposterior dimensionAnatomical basisAnteroposterior lengthPosterior widthMorphological Basis for Airway Surgical Intervention in Apert Syndrome
Lu X, Forte AJ, Park KE, Allam O, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Morphological Basis for Airway Surgical Intervention in Apert Syndrome. Annals Of Plastic Surgery 2020, 87: 59-64. PMID: 34133365, DOI: 10.1097/sap.0000000000002601.Peer-Reviewed Original ResearchConceptsApert syndrome patientsPharyngeal airway volumeComputed tomography scanSyndrome patientsApert syndromeAirway volumeSurgical interventionTomography scanNasal cavityPreoperative computed tomography scansAirway volume changesAge-related subgroupsYears of ageMonths of agePosition of maxillaGrowth of mandibleAirway compromiseNasopharyngeal airwayPharyngeal airwayNasal airwayIntergonial widthSyndromeAirwayPatientsAnteroposterior lengthAirway Development Relevant to Cranial Vault Suture Synostosis Subtype in Apert Syndrome
Lu X, Forte A, Park K, Allam O, Steinbacher D, Alperovich M, Passos-Bueno M, Tonello C, Alonso N, Persing J. Airway Development Relevant to Cranial Vault Suture Synostosis Subtype in Apert Syndrome. FACE 2020, 1: 89-96. DOI: 10.1177/2732501620973030.Peer-Reviewed Original ResearchPharyngeal airwayAirway volumeNasal airwayApert patientsCT scanNasal cavityCross-sectional areaApert syndromeSuture synostosisNasopharyngeal airway volumePharyngeal airway volumeAirway volume changesDecreased cross-sectional areaType IIIBilateral coronal synostosisType IIAirway developmentSyndrome subtypesCranial base angulationAirwayEstablished classification systemPatientsSurgical planningSectional areaCoronal synostosisRacial disparity of Crouzon syndrome in maxilla and mandible
Lu X, Forte AJ, Fan F, Zhang Z, Teng L, Yang B, Alperovich M, Steinbacher DM, Alonso N, Persing JA. Racial disparity of Crouzon syndrome in maxilla and mandible. International Journal Of Oral And Maxillofacial Surgery 2020, 49: 1566-1575. PMID: 32362538, DOI: 10.1016/j.ijom.2020.04.005.Peer-Reviewed Original ResearchConceptsAsian patientsCaucasian patientsCrouzon syndrome patientsCrouzon syndromeSyndrome patientsRacial disparitiesAnteroposterior maxillary lengthMidface profileTomography scanPatientsMandibular volumeCaucasian controlsCraniosynostosis patientsMaxillary positioningMaxillary lengthSyndromeVolume deficiencyANB angleAsian controlsMandibular lengthBackward displacementMaterialise softwareMaxillaSame extentMaxilla length
2022
Imaging biomarkers for diagnosis and treatment response in patients with lymphedema
Maita K, Garcia JP, Torres RA, Avila FR, Kaplan JL, Lu X, Manrique OJ, Ciudad P, Forte AJ. Imaging biomarkers for diagnosis and treatment response in patients with lymphedema. Biomarkers In Medicine 2022, 16: 303-316. PMID: 35176878, DOI: 10.2217/bmm-2021-0487.Peer-Reviewed Original ResearchEffect of health care disparities on procedure selection of autologous breast reconstruction in Florida.
Huayllani MT, Torres-Guzman RA, Avila FR, Advani PP, Spaulding AC, Cochuyt JJ, Nguyen MT, Lu X, Rinker BD, Forte AJ. Effect of health care disparities on procedure selection of autologous breast reconstruction in Florida. Breast Disease 2022, 41: 75-80. PMID: 34487016, DOI: 10.3233/bd-210004.Peer-Reviewed Original ResearchConceptsAutologous breast reconstructionBreast reconstructionFree flapFlap reconstructionReconstructive surgeryAutologous breast reconstructive surgeryFlorida Inpatient Discharge DatasetPatients 18 yearsBreast reconstructive surgeryMultivariate logistic regressionPedicled flap reconstructionHealth care disparitiesMann-Whitney testHispanic patientsIndependent associationAutologous reconstructionBreast cancerHigher oddsPatientsCare disparitiesPedicled flapsProcedure selectionLogistic regressionPrivate insuranceFlap
2021
The Impact of implant-based reconstruction on persistent pain after breast cancer surgery: A systematic review
Guliyeva G, Torres RA, Avila FR, Kaplan JL, Lu X, Forte AJ. The Impact of implant-based reconstruction on persistent pain after breast cancer surgery: A systematic review. Journal Of Plastic Reconstructive & Aesthetic Surgery 2021, 75: 519-527. PMID: 34801428, DOI: 10.1016/j.bjps.2021.09.079.Peer-Reviewed Original ResearchConceptsBreast cancer surgeryPersistent painCancer surgeryFrequency of analgesicsPlastic surgeonsBreast cancer survivorsFull-text articlesAppropriate reconstruction techniqueCancer survivorsSurgical techniqueImplant reconstructionEligible articlesSystematic reviewPPBCTFinal reviewSame dosagePatientsRelevant articlesIncreased chanceLower chancePainSurgerySurgeonsMost studiesScopus databasesDoes different cranial suture synostosis influence orbit volume and morphology in Apert syndrome?
Lu X, Forte A, Alperovich M, Alonso N, Persing J. Does different cranial suture synostosis influence orbit volume and morphology in Apert syndrome? International Journal Of Oral And Maxillofacial Surgery 2021, 51: 338-346. PMID: 34400025, DOI: 10.1016/j.ijom.2021.07.019.Peer-Reviewed Original ResearchConceptsApert syndrome patientsSyndrome patientsBone volumeApert syndromeBicoronal synostosisType IType IIISuture synostosisComputed tomography scanType IIMaxillary bone volumeIndividualized surgical planningOrbital cavity volumeBilateral coronal synostosisTomography scanAnatomic basisBone malformationsSurgical planningSynostosisCoronal synostosisOrbital rimStatistical significanceOrbit volumePatientsSyndromeFacial Dysmorphology in Saethre-Chotzen Syndrome
Junn A, Dinis J, Lu X, Forte AJ, Mozaffari MA, Phillips S, Lopez J, Alonso N, Persing JA, Alperovich M. Facial Dysmorphology in Saethre-Chotzen Syndrome. Journal Of Craniofacial Surgery 2021, 32: 2660-2665. PMID: 34727468, DOI: 10.1097/scs.0000000000007910.Peer-Reviewed Original ResearchConceptsSCS patientsSaethre-Chotzen syndromeMandibular prognathismNonsyndromic patientsNasal bridgePreoperative computer-tomography (CT) scanNasal boneNonsyndromic craniosynostosis patientsB point angleProminent nasal bridgeBroad nasal bridgeMann-Whitney UComputer tomography scansEyelid ptosisTomography scanMaxillary retrusionSuture pathologyNormal controlsMaxillary hypoplasiaPatientsClassic featuresCraniosynostosis patientsUnaffected controlsSyndromeClassic descriptionTreatment Contraindications Based on Comorbidity Status in Patients With Melanoma in the United States
Boczar D, Bagaria SP, Spaulding AC, Huayllani MT, Avila FR, Guliyeva G, Lu X, Rinker BD, Forte AJ. Treatment Contraindications Based on Comorbidity Status in Patients With Melanoma in the United States. Anticancer Research 2021, 41: 2067-2070. PMID: 33813415, DOI: 10.21873/anticanres.14976.Peer-Reviewed Original ResearchConceptsNational Cancer DatabaseMultivariate logistic regressionComorbid conditionsTreatment contraindicationsGovernment insuranceLogistic regressionUnknown treatment statusMost patientsPatient demographicsComorbidity statusCurative treatmentMelanoma patientsCancer DatabaseIndependent associationOncological patientsMelanoma incidenceTreatment decisionsInclusion criteriaHigher oddsMelanoma treatmentTreatment statusPatientsPoor candidatesPatient treatmentPrivate insuranceConformity of the Virtual Surgical Plan to the Actual Result Comparing Five Craniofacial Procedure Types.
Maniskas S, Pourtaheri N, Chandler L, Lu X, Bruckman KC, Steinbacher DM. Conformity of the Virtual Surgical Plan to the Actual Result Comparing Five Craniofacial Procedure Types. Plastic & Reconstructive Surgery 2021, 147: 915-924. PMID: 33776034, DOI: 10.1097/prs.0000000000007776.Peer-Reviewed Original ResearchConceptsVirtual surgical planningProcedure typeCranial vault remodelingSurgical planningOrthognathic surgeryMandibular distractionVault remodelingMandible reconstructionActual postoperative outcomesVirtual surgical planPostoperative outcomesConsecutive patientsMore predictable resultsSingle surgeonExcellent outcomesTomographic scanSkeletal repositioningPostoperative movementSurgical planBonferroni analysisIntraoperative judgmentIntraoperative guidePermanent implantsPatientsSurgeryUse of magnetic resonance imaging lymphangiography for preoperative planning in lymphedema surgery: A systematic review
Forte AJ, Boczar D, Huayllani MT, Avila FR, Guliyeva G, Lu X, Mash WR, Kung TA. Use of magnetic resonance imaging lymphangiography for preoperative planning in lymphedema surgery: A systematic review. Microsurgery 2021, 41: 384-390. PMID: 33710683, DOI: 10.1002/micr.30731.Peer-Reviewed Original ResearchConceptsLymphovenous anastomosisPreoperative planningSystematic reviewLymphedema surgeryLymphedema patientsAdverse effectsStandard preoperative evaluationCochrane Clinical AnswersPubMed/MEDLINEMagnetic resonance imagingLymphatic vessel abnormalitiesSecondary outcomesPrimary outcomePreoperative evaluationPreoperative protocolEmbase databasesLymphedema diagnosisEligibility criteriaStandard examinationSurgeryPatientsVessel abnormalitiesResonance imagingPotential articlesTreatment evaluationCephalocranial Disproportionate Fossa Volume and Normal Skull Base Angle in Pfeiffer Syndrome.
Lu X, Forte AJ, Allam O, Park KE, Alperovich M, Steinbacher DM, Tonello C, Alonso N, Persing JA. Cephalocranial Disproportionate Fossa Volume and Normal Skull Base Angle in Pfeiffer Syndrome. Journal Of Craniofacial Surgery 2021, 32: 581-586. PMID: 33704985, DOI: 10.1097/scs.0000000000007203.Peer-Reviewed Original ResearchConceptsPfeiffer syndrome patientsMiddle cranial fossaCranial fossaSyndrome patientsFossa volumePfeiffer patientsSurgical interventionSuture synostosisPfeiffer syndromePreoperative CT scanPosterior cranial fossa volumeAnterior cranial fossaSkull base developmentSkull base angleClinical manifestationsCraniosynostosis disordersCT scanPosterior fossaNormal controlsAnatomic basisAnterior fossaPatientsSquamosal synostosisStructural abnormalitiesSubgroup comparisonsAge as a risk factor for breast cancer-related lymphedema: a systematic review
Guliyeva G, Huayllani MT, Boczar D, Avila FR, Lu X, Forte AJ. Age as a risk factor for breast cancer-related lymphedema: a systematic review. Journal Of Cancer Survivorship 2021, 17: 246-253. PMID: 33486706, DOI: 10.1007/s11764-021-00994-z.Peer-Reviewed Original ResearchConceptsCancer-related lymphedemaRisk factorsBreast cancer-related lymphedemaPossible risk factorsLevel of evidenceDevelopment of lymphedemaBCRL developmentEffect of agePatient characteristicsDisease entityOvid MEDLINEAverage ageSystematic reviewMedical literaturePatientsRelevant articlesLymphedemaFinal analysisAgeIndividual studiesDifferent findingsEffect relationshipMethodsPubMedReviewMEDLINE