2006
Cytogenetics of Hispanic and White Children with Acute Lymphoblastic Leukemia in California
Aldrich MC, Zhang L, Wiemels JL, Ma X, Loh ML, Metayer C, Selvin S, Feusner J, Smith MT, Buffler PA. Cytogenetics of Hispanic and White Children with Acute Lymphoblastic Leukemia in California. Cancer Epidemiology Biomarkers & Prevention 2006, 15: 578-581. PMID: 16537719, DOI: 10.1158/1055-9965.epi-05-0833.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAge DistributionCaliforniaChildChild, PreschoolCohort StudiesCore Binding Factor Alpha 2 SubunitCytogeneticsFemaleGene Expression Regulation, NeoplasticGenetic MarkersGenetic Predisposition to DiseaseHispanic or LatinoHumansIn Situ Hybridization, FluorescenceIncidenceInfantMaleOncogene Proteins, FusionPloidiesPrecursor Cell Lymphoblastic Leukemia-LymphomaProbabilityProspective StudiesRisk FactorsSensitivity and SpecificitySeverity of Illness IndexSex DistributionSurvival RateWhite PeopleConceptsAcute lymphoblastic leukemia patientsNon-Hispanic whitesLymphoblastic leukemia patientsLeukemia patientsB-lineage acute lymphoblastic leukemia patientsNorthern California Childhood Leukemia StudyPopulation-based studyAcute lymphoblastic leukemiaCalifornia Childhood Leukemia StudyChildhood Leukemia StudyChildhood leukemia patientsEthnic-specific risk factorsTEL-AML1 translocationSitu hybridization findingsTumor genetic characteristicsLymphoblastic leukemiaRisk factorsEpidemiologic studiesHigh hyperdiploidyTEL-AML1Childhood leukemiaCytogenetic profilePatientsMLL rearrangementsLeukemia Study
2005
Cytogenetics of Hispanics and Whites with Childhood Acute Lymphoblastic Leukemia in California.
Aldrich M, Zhang L, Wiemels J, Ma X, Loh M, Selvin S, Feusner J, Smith M, Buffler P. Cytogenetics of Hispanics and Whites with Childhood Acute Lymphoblastic Leukemia in California. Blood 2005, 106: 4536. DOI: 10.1182/blood.v106.11.4536.4536.Peer-Reviewed Original ResearchNon-Hispanic whitesChildhood leukemia patientsRisk factorsLeukemia patientsMLL rearrangementsChildhood acute lymphoblastic leukemiaNorthern California Childhood Leukemia StudyPopulation-based studyAcute lymphoblastic leukemiaCalifornia Childhood Leukemia StudyChildhood Leukemia StudyFirst large studyEthnic-specific risk factorsTEL-AML1 translocationSitu hybridization findingsTumor genetic characteristicsCytogenetic characteristicsHeterogeneity of leukemiaLymphoblastic leukemiaEpidemiologic studiesHigh hyperdiploidyTEL-AML1Childhood leukemiaCytogenetic profileDistinct etiologiesRAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia
Wiemels JL, Zhang Y, Chang J, Zheng S, Metayer C, Zhang L, Smith MT, Ma X, Selvin S, Buffler PA, Wiencke JK. RAS mutation is associated with hyperdiploidy and parental characteristics in pediatric acute lymphoblastic leukemia. Leukemia 2005, 19: 415-419. PMID: 15674422, DOI: 10.1038/sj.leu.2403641.Peer-Reviewed Original ResearchConceptsRAS mutationsMaternal ageLeukemia casesPediatric acute lymphoblastic leukemiaAcute lymphoblastic leukemia casesDiagnostic bone marrow samplesIncident leukemia casesPaternal preconception smokingNorthern California Childhood Leukemia StudyAcute lymphoblastic leukemiaLymphoblastic leukemia casesBone marrow samplesKRAS codon 12California Childhood Leukemia StudyRAS gene mutationsChildhood Leukemia StudyEtiology of subtypesPreconception smokingCase seriesLymphoblastic leukemiaLeukemia patientsMultivariable modelMarrow samplesHigh hyperdiploidyChildhood leukemia
2004
Hypermethylation of the 5′ CpG Island of the FHIT Gene Is Associated with Hyperdiploid and Translocation-Negative Subtypes of Pediatric Leukemia
Zheng S, Ma X, Zhang L, Gunn L, Smith MT, Wiemels JL, Leung K, Buffler PA, Wiencke JK. Hypermethylation of the 5′ CpG Island of the FHIT Gene Is Associated with Hyperdiploid and Translocation-Negative Subtypes of Pediatric Leukemia. Cancer Research 2004, 64: 2000-2006. PMID: 15026336, DOI: 10.1158/0008-5472.can-03-2387.Peer-Reviewed Original ResearchMeSH KeywordsAcid Anhydride HydrolasesAdolescentAntimetabolites, AntineoplasticAzacitidineB-LymphocytesChildChild, PreschoolChromosomes, Human, Pair 12Chromosomes, Human, Pair 21CpG IslandsDecitabineDiploidyDNA MethylationDNA, NeoplasmFemaleGene DeletionGene Expression Regulation, NeoplasticHumansLeukemia, MyeloidMaleNeoplasm ProteinsPrecursor Cell Lymphoblastic Leukemia-LymphomaPromoter Regions, GeneticT-LymphocytesTranslocation, GeneticTumor Cells, CulturedConceptsPediatric leukemiaFHIT geneB cellsLeukemia cell linesFHIT methylation statusHigh WBC countPopulation-based casesChildhood leukemia patientsCell linesHyperdiploid B cellsHypermethylation of FHITPrognostic indicatorWBC countMethylation-specific PCRLeukemia patientsMyeloid leukemiaCytogenetic subtypesLoss of heterozygosityBone marrowFHIT expressionPrimary leukemiasFHIT inactivationFHIT methylationHuman malignanciesLeukemia