2015
The novel tumor angiogenic factor, adrenomedullin-2, predicts survival in pancreatic adenocarcinoma
Hollander LL, Guo X, Salem RR, Cha CH. The novel tumor angiogenic factor, adrenomedullin-2, predicts survival in pancreatic adenocarcinoma. Journal Of Surgical Research 2015, 197: 219-224. PMID: 25982376, DOI: 10.1016/j.jss.2014.11.002.Peer-Reviewed Original ResearchConceptsMitogen-activated protein kinase/extracellular signal-regulated kinaseProtein kinase/extracellular signal-regulated kinaseExtracellular signal-regulated kinaseSignal-regulated kinaseTotal cellular levelsAdrenomedullin 2Tumor angiogenesis factorVascular endothelial growth factor 2Microarray technologyGrowth factor 2Cellular levelNovel therapeutic targetPancreatic cancer tissuesProtein expressionFactor 2Angiogenesis factorsTherapeutic targetTumor angiogenic factorsTumor angiogenesisAngiogenic rolePotential roleWorse histologic gradePossible roleCancer tissuesPancreas cancer
2014
Automated Quantitative Analysis of Tissue Microarray of 443 Patients with Colorectal Adenocarcinoma: Low Expression of Bcl-2 Predicts Poor Survival
Nicholson AD, Guo X, Sullivan CA, Cha CH. Automated Quantitative Analysis of Tissue Microarray of 443 Patients with Colorectal Adenocarcinoma: Low Expression of Bcl-2 Predicts Poor Survival. Journal Of The American College Of Surgeons 2014, 219: 977-987. PMID: 25127509, DOI: 10.1016/j.jamcollsurg.2014.07.007.Peer-Reviewed Original ResearchConceptsDisease-specific survivalBcl-2 expressionColorectal cancerOverall survivalPoor disease-specific survivalCox proportional hazards modelIndependent prognostic factorSubset of patientsColorectal adenocarcinoma samplesLog-rank testBcl-2Proportional hazards modelSemi-quantitative grading methodsColorectal cancer samplesNumber of cancersPrognostic factorsT stageChemotherapy choiceClinicopathologic variablesColorectal adenocarcinomaUnivariate analysisPatient outcomesPoor survivalTissue microarrayAggressive phenotype