Woo Sub Yang
Associate Research Scientist in GeneticsAbout
Research
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2026
Bidens pilosa extract and bentonite, a phytogenic formulation, as a feed additive to improve diarrhea and gut microbiota in calves: Effects on feed use and regulation of gut microbiota
Lee Y, Kuo T, Yang G, Liang Y, Yang W. Bidens pilosa extract and bentonite, a phytogenic formulation, as a feed additive to improve diarrhea and gut microbiota in calves: Effects on feed use and regulation of gut microbiota. Veterinary And Animal Science 2026, 34: 100732. DOI: 10.1016/j.vas.2026.100732.Peer-Reviewed Original Researchgut microbiotabacterial generaregulation of gut microbiotafeces of calvesculture-based methodsHolstein-Friesian calvesrRNA sequencingmetagenomic analysisintestine of calvesgrowth of bacteriabody weight gainpathogenic potentialmicrobiotabacterial growthfecal IgA levelsBidens pilosa extractfecal scoreFriesian calvesgrowth performancefeed usegutfeed additivesgenuslivestock industryanimal healthRegulation of Nosema ceranae gene expression by Bidens pilosa phytogenic treatment in infected honey bees
Li Y, Chen K, Chang J, Chang Z, Ko C, Ho S, Chen L, Wu M, Yang W, Yang Y, Chen Y, Nai Y. Regulation of Nosema ceranae gene expression by Bidens pilosa phytogenic treatment in infected honey bees. Frontiers In Insect Science 2026, 6: 1828903. PMID: 42318229, PMCID: PMC13273367, DOI: 10.3389/finsc.2026.1828903.Peer-Reviewed Original Researchbee midgutV-type ATPasehoney beespathogen loadhoney bee midguttranscriptome profilingdays post-infectionmolecular basisgene expressioninfected honey beeslaboratory cage experimentsearly infection stageRNAi-mediated knockdownphytogenic extractsworker beesmicrosporidian parasitepost-infectionstage-dependent mannerinfection stagescage experimentsGene OntologyRNAi resultstranscriptome analysisbeesparasite genesHuman amygdala-like telencephalic organoids model stress circuitry in assembloid systems
Yang W, Choe M, Lo C, Liu H, Cho Y, Kim J, Kiral F, Scandura M, Lu X, Kim K, Na K, Qiu C, Wu F, Dirks A, Mathew R, Cakir B, Cha H, Kim S, Cox A, Chung S, Jiang Y, Shin K, Lee S, Park I. Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems. Cell Stem Cell 2026, 33: 1144-1160.e9. PMID: 42184826, PMCID: PMC13289835, DOI: 10.1016/j.stem.2026.04.021.Peer-Reviewed Original ResearchConceptsstress-related disordersstress circuitrylimbic circuitsneuropsychiatric disordersstress responseunrecognized mechanismstress response signalingsynaptic regulationexposure to cortisolcircuit-level analysisamygdalaretrotransposon biologydisordersnoncoding RNAscircuitryendocrine signalsregion-specific developmentanxietymolecular featuresemotionsA New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation
Lee Y, Kuo T, Yang C, Yang G, Yang W. A New Vista of Opportunity in Diabetes Management: Natural Product‐Based β‐cell Preservation. Food Chemistry International 2026 DOI: 10.1002/fci2.70065.Peer-Reviewed Original Researchpositive regulatorresistance to cell deathnegative regulatorinsulin synthesis/secretionB cell homeostasisB cellscell deathnatural compoundsOphiocordyceps sinensisregulation of B cellsmolecular mechanismsdisease developmentstructural classesB-cell massPeganum harmalainsulin secretionmolecular targetsnatural inhibitorfunctional B cellstarget identificationnatural productsBidens pilosadatabase searchCurcuma longaMolecular and Mechanistic Divergence of Seizures in Pediatric Acute Lymphoblastic Leukemia: CNS Infiltration Versus Chemotherapy-Induced Neurotoxicity
Joo J, Yang W, Koh H. Molecular and Mechanistic Divergence of Seizures in Pediatric Acute Lymphoblastic Leukemia: CNS Infiltration Versus Chemotherapy-Induced Neurotoxicity. International Journal Of Molecular Sciences 2026, 27: 3307. PMID: 41977486, PMCID: PMC13073153, DOI: 10.3390/ijms27073307.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsStructure–Property–Function Relationships in Stimuli-Responsive Hydrogels for Brain Organoid Vascularization
Kim M, Choi H, Yang W, Koh H. Structure–Property–Function Relationships in Stimuli-Responsive Hydrogels for Brain Organoid Vascularization. Gels 2026, 12: 287. PMID: 42042125, PMCID: PMC13116992, DOI: 10.3390/gels12040287.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsCannabidiol in Developmental Epilepsy: Organoid-Guided Precision Medicine Across Critical Neurodevelopmental Windows
Joo J, Yang W, Koh H. Cannabidiol in Developmental Epilepsy: Organoid-Guided Precision Medicine Across Critical Neurodevelopmental Windows. International Journal Of Molecular Sciences 2026, 27: 2899. PMID: 41898755, PMCID: PMC13026608, DOI: 10.3390/ijms27062899.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPatient‐Specific Computational Flow Simulation Reveals Adverse Hemodynamic Factors Associated With Occlusion of Directional Branches After Fenestrated‐Branched Endovascular Aneurysm Repair
Tran K, Chait J, Tenorio E, Yang W, Marsden A, Mendes B, Lee J, Oderich G. Patient‐Specific Computational Flow Simulation Reveals Adverse Hemodynamic Factors Associated With Occlusion of Directional Branches After Fenestrated‐Branched Endovascular Aneurysm Repair. Journal Of The American Heart Association 2026, 15: e044790. PMID: 41614309, PMCID: PMC13055448, DOI: 10.1161/jaha.125.044790.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Aneurysm, ThoracicBlood Vessel ProsthesisBlood Vessel Prosthesis ImplantationComputed Tomography AngiographyComputer SimulationEndovascular Aneurysm RepairEndovascular ProceduresFemaleGraft Occlusion, VascularHemodynamicsHumansMaleMiddle AgedModels, CardiovascularPatient-Specific ModelingProsthesis DesignRetrospective StudiesRisk FactorsStentsTreatment OutcomeConceptstime-averaged wall shear stressrigid-walled simulationscomputational flow simulationswall shear stressshear stressflow simulationsendovascular aneurysm repairindividual geometryboundary conditionssurface areaaneurysm repairassociated with occlusionbranch occlusionsimulationpostoperative areaIV thoracoabdominal aortic aneurysmsocclusion probabilityrenal branch occlusionSimVascularthoracoabdominal aortic aneurysmsmesenteric branchesbranch vessel occlusionreceiver operating characteristic curvePoria cocos as a Functional Food for Diabetes and Diabetes‐Related Foot Ulcers
Lee Y, Kuo T, Yang G, Yang W. Poria cocos as a Functional Food for Diabetes and Diabetes‐Related Foot Ulcers. 2026, 2: 30-38. DOI: 10.1002/agf2.70010.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus Statements
2025
Generation of human pineal gland organoids with melatonin production for disease modeling
Kiral F, Yang W, Iyilikci O, Lu X, Kim J, Choe M, Lo C, Zhong M, Kim K, Jiang Y, Park I. Generation of human pineal gland organoids with melatonin production for disease modeling. Cell Stem Cell 2025, 33: 91-107.e9. PMID: 41475351, PMCID: PMC12925488, DOI: 10.1016/j.stem.2025.12.004.Peer-Reviewed Original ResearchConceptssingle-cell RNA sequencingAngelman syndromepineal developmentcell therapy approachespatient-derived iPSCsRNA sequencingtranscriptome profilingpluripotent stem cellssleep-related disorderscircadian regulationpineal glandmelatonin productionadrenergic receptorspinealectomized micephysiological regulationhuman studiestissue accessstem cellsdevelopmental pathologymelatonin synthesisdisease modelsdisease-related impairmentmelatonincircadian rhythmregulation
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Yale Only Bong Ihn Koh - Woo Sub Yang