Kun-Yong Kim, PhD
Associate Research Scientist in GeneticsCards
About
Research
Publications
2026
Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems
Yang W, Choe M, Lo C, Liu H, Cho Y, Kim J, Kiral F, Scandura M, Lu X, Kim K, Na K, Qiu C, Wu F, Dirks A, Mathew R, Cakir B, Cha H, Kim S, Cox A, Chung S, Jiang Y, Shin K, Lee S, Park I. Human amygdala-like telencephalic organoids model stress circuitry in assembloid systems. Cell Stem Cell 2026, 33: 1144-1160.e9. PMID: 42184826, PMCID: PMC13289835, DOI: 10.1016/j.stem.2026.04.021.Peer-Reviewed Original ResearchConceptsStress-related disordersStress circuitryLimbic circuitsNeuropsychiatric disordersStress responseUnrecognized mechanismStress response signalingSynaptic regulationExposure to cortisolCircuit-level analysisAmygdalaRetrotransposon biologyDisordersNoncoding RNAsCircuitryEndocrine signalsRegion-specific developmentAnxietyMolecular featuresEmotions
2025
Generation of human pineal gland organoids with melatonin production for disease modeling
Kiral F, Yang W, Iyilikci O, Lu X, Kim J, Choe M, Lo C, Zhong M, Kim K, Jiang Y, Park I. Generation of human pineal gland organoids with melatonin production for disease modeling. Cell Stem Cell 2025, 33: 91-107.e9. PMID: 41475351, PMCID: PMC12925488, DOI: 10.1016/j.stem.2025.12.004.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingAngelman syndromePineal developmentCell therapy approachesPatient-derived iPSCsRNA sequencingTranscriptome profilingPluripotent stem cellsSleep-related disordersCircadian regulationPineal glandMelatonin productionAdrenergic receptorsPinealectomized micePhysiological regulationHuman studiesTissue accessStem cellsDevelopmental pathologyMelatonin synthesisDisease modelsDisease-related impairmentMelatoninCircadian rhythmRegulationFunctional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches
Cakir B, Tanaka Y, Choe M, Chu P, Xiang Y, Kim K, Zhong M, Gelernter J, Zhang H, Krystal J, Park I. Functional Validation of Alcohol Dependence-Associated FYN Variants Using Gene Editing and Stem Cell Study Approaches. International Journal Of Stem Cells 2025, 18: 263-274. PMID: 40205763, PMCID: PMC12394083, DOI: 10.15283/ijsc24123.Peer-Reviewed Original ResearchHuman embryonic stem cell linesAlcohol dependenceAD-associated variantsEmbryonic stem cell linesReporter gene analysisFyn tyrosine kinase geneTyrosine kinase geneStem cell linesCRISPR-Cas9 editingAssociated with ADVulnerability to ADAD-associatedKinase geneC alleleC/T allelesMultiple polymorphismsFunctional validationGene analysisEthanol treatmentNeuropsychiatric disordersInduced neuronsAD treatmentGene editingCell linesDisease mechanisms
2018
Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain Organoids
Xiang Y, Yoshiaki T, Patterson B, Cakir B, Kim K, Cho YS, Park I. Generation and Fusion of Human Cortical and Medial Ganglionic Eminence Brain Organoids. Current Protocols In Stem Cell Biology 2018, 47: e61. PMID: 30854156, PMCID: PMC6402040, DOI: 10.1002/cpsc.61.Peer-Reviewed Original ResearchConceptsMedial ganglionic eminenceBrain organoidsBrain regionsBrain developmentSpecific brain regionsDifferent brain regionsHuman CorticalHuman brain developmentCortical organoidsGanglionic eminenceNeurological disordersInterneuron migrationSpecific regionalizationOrganoid culturesOrganoidsBrain organoid culture
2012
The lesser known story of X chromosome reactivation
Hysolli E, Tanaka Y, Kim K, Jung Y, Park IH. The lesser known story of X chromosome reactivation. Cell Cycle 2012, 11: 229-235. PMID: 22234239, PMCID: PMC3293375, DOI: 10.4161/cc.11.2.18998.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsX chromosome reactivationX-chromosome inactivationInner cell massActive histone marksGerm cell formationX inactivation signalHistone marksActive chromosomeCellular reprogrammingInactivation signalGene poolPluripotent cellsKey regulatorFemale cellsGene expressionGerm layersCell formationXY cellsCell massImportant mechanismNatural occurrenceCellsReprogrammingChromosomesGenes