2023
SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia
Willet S, Thanintorn N, McNeill H, Huh S, Ornitz D, Huh W, Hoft S, DiPaolo R, Mills J. SOX9 Governs Gastric Mucous Neck Cell Identity and Is Required for Injury-Induced Metaplasia. Cellular And Molecular Gastroenterology And Hepatology 2023, 16: 325-339. PMID: 37270061, PMCID: PMC10444955, DOI: 10.1016/j.jcmgh.2023.05.009.Peer-Reviewed Original ResearchConceptsSRY-box transcription factor 9Cell identityAdult homeostasisGastric progenitorsMucous neck cellsZymogenic chief cellsGastric developmentNeck cellsPotential genesMaster regulatorExpression patternsGene expressionSPEM cellsCell differentiationCorpus unitsSOX9 expressionSOX9Factor 9Specific expansionHomeostasisMisexpressionSox9 deletionReprogrammingChief cellsGenetic deletion
2013
Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3
Geahlen JH, Lapid C, Thorell K, Nikolskiy I, Huh WJ, Oates EL, Lennerz JK, Tian X, Weis VG, Khurana SS, Lundin SB, Templeton AR, Mills JC. Evolution of the human gastrokine locus and confounding factors regarding the pseudogenicity of GKN3. Physiological Genomics 2013, 45: 667-683. PMID: 23715263, PMCID: PMC3742967, DOI: 10.1152/physiolgenomics.00169.2012.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCarrier ProteinsComputational BiologyDNA PrimersEvolution, MolecularFluorescent Antibody TechniqueGastric MucosaGenetic LociGenetics, PopulationGenotypeHaplotypesHumansLikelihood FunctionsMacaca mulattaMembrane ProteinsMiceMice, Inbred C57BLMicroarray AnalysisMicroscopy, ConfocalModels, GeneticMutationPhylogenyPolymorphism, Single NucleotidePseudogenesRacial GroupsSelection, GeneticSpecies SpecificitySus scrofaConceptsSelective sweepsHuman genetic locusGenome evolutionGenomic neighborsSplice donor siteDirectional selectionHuman genomeGenetic lociBp downstreamEuropean genesGKN3Gastric mucous neck cellsStop codon mutationThird memberHuman populationGenesCodon mutationLociGKN2Haplotype analysisMucous neck cellsMutationsAfrican populationsNeck cellsGKN1