Inhibition of human platelet aggregation by endothelium-derived relaxing factor, sodium nitroprusside or iloprost is potentiated by captopril and reduced thiols.
Mollace V, Salvemini D, Sessa W, Vane J. Inhibition of human platelet aggregation by endothelium-derived relaxing factor, sodium nitroprusside or iloprost is potentiated by captopril and reduced thiols. Journal Of Pharmacology And Experimental Therapeutics 1991, 258: 820-3. PMID: 1716310.Peer-Reviewed Original ResearchConceptsPlatelet aggregationSodium nitroprussideAntiaggregatory effectAngiotensin-converting enzyme inhibitorOxygen-derived free radicalsInhibitors of angiotensinHuman platelet aggregationSulfhydryl-containing compoundsCyclic AMP levelsPlatelet cyclic GMPAggregatory responsePotentiating effectTeprotideAntiplatelet compoundsEnzyme inhibitorsEnalaprilatAntiaggregatory propertiesAMP levelsIloprostEndothelial cellsIntracellular scavengerNitroprussideCyclic GMPNACBovine aorta