Small‐Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α
Buckley DL, Gustafson JL, Van Molle I, Roth AG, Tae HS, Gareiss PC, Jorgensen WL, Ciulli A, Crews CM. Small‐Molecule Inhibitors of the Interaction between the E3 Ligase VHL and HIF1α. Angewandte Chemie International Edition 2012, 51: 11463-11467. PMID: 23065727, PMCID: PMC3519281, DOI: 10.1002/anie.201206231.Peer-Reviewed Original ResearchMeSH KeywordsCrystallography, X-RayDrug DesignEnzyme InhibitorsHumansHypoxia-Inducible Factor 1, alpha SubunitInhibitory Concentration 50Models, MolecularProtein Interaction MapsVon Hippel-Lindau Tumor Suppressor Protein