2017
JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules
Newton AS, Deiana L, Puleo DE, Cisneros J, Cutrona KJ, Schlessinger J, Jorgensen WL. JAK2 JH2 Fluorescence Polarization Assay and Crystal Structures for Complexes with Three Small Molecules. ACS Medicinal Chemistry Letters 2017, 8: 614-617. PMID: 28626520, PMCID: PMC5467202, DOI: 10.1021/acsmedchemlett.7b00154.Peer-Reviewed Original Research
2004
Relationship between Side Chain Structure and 14-Helix Stability of β3-Peptides in Water
Kritzer JA, Tirado-Rives J, Hart SA, Lear JD, Jorgensen WL, Schepartz A. Relationship between Side Chain Structure and 14-Helix Stability of β3-Peptides in Water. Journal Of The American Chemical Society 2004, 127: 167-178. PMID: 15631466, PMCID: PMC2873033, DOI: 10.1021/ja0459375.Peer-Reviewed Original ResearchConceptsAlpha-helix foldingSide chain structureChain structureSolution-phase calculationsClass of foldamersSide-chain hydrogen bondingSide-chain carbonsAlpha-amino acidsHydrogen bondingΒ3‐PeptidesMacromolecular targetsChain carbonsRational designSuch moleculesConsiderable current interestDiverse functionalitiesFoldamersAlpha-helix propensityPolymersExperimental trendsAmino acidsSimilar versatilityAcidHomothreonineStructure