Relationship between Side Chain Structure and 14-Helix Stability of β3-Peptides in Water
Kritzer JA, Tirado-Rives J, Hart SA, Lear JD, Jorgensen WL, Schepartz A. Relationship between Side Chain Structure and 14-Helix Stability of β3-Peptides in Water. Journal Of The American Chemical Society 2004, 127: 167-178. PMID: 15631466, PMCID: PMC2873033, DOI: 10.1021/ja0459375.Peer-Reviewed Original ResearchConceptsAlpha-helix foldingSide chain structureChain structureSolution-phase calculationsClass of foldamersSide-chain hydrogen bondingSide-chain carbonsAlpha-amino acidsHydrogen bondingΒ3‐PeptidesMacromolecular targetsChain carbonsRational designSuch moleculesConsiderable current interestDiverse functionalitiesFoldamersAlpha-helix propensityPolymersExperimental trendsAmino acidsSimilar versatilityAcidHomothreonineStructure